FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135298082> ?p ?o ?g. }

• W2135298082 endingPage "943" @default.
• W2135298082 startingPage "933" @default.
• W2135298082 abstract "The mature bovine cathepsin C (CC) molecule is composed of four identical monomers, each proteolytically processed into three chains. Five intrachain disulfides and three nonpaired cysteine residues per monomer were identified. Beside catalytic Cys234 in the active site, free-thiol Cys331 and Cys424 were characterized. Cys424 can be classified as inaccessible buried residue. Selective modification of Cys331 results in dissociation of native CC tetramer into dimers. The 3D homology-based model of the CC catalytic core suggests that Cys331 becomes exposed as the activation peptide is removed during procathepsin C activation. The model further shows that exposed Cys331 is surrounded by a surface hydrophobic cluster, unique to CC, forming a dimer-dimer interaction interface. Substrate/inhibitor recognition of the active site in the CC dimer differs significantly from that in the native tetramer. Taken together, a mechanism is proposed that assumes that the CC tetramer formation results in a site-specific occlusion of endopeptidase-like active site cleft of each CC monomeric unit. Thus, tetramerization provides for the structural basis of the dipeptidyl peptidase activity of CC through a substrate access-limiting mechanism different from those found in homologous monomeric exopeptidases cathepsin H and B. In conclusion, the mechanism of tetramer formation as well as specific posttranslational processing segregates CC in the family of papain proteases." @default.
• W2135298082 created "2016-06-24" @default.
• W2135298082 creator A5002895668 @default.
• W2135298082 creator A5031295914 @default.
• W2135298082 creator A5031688867 @default.
• W2135298082 creator A5043850848 @default.
• W2135298082 creator A5049132537 @default.
• W2135298082 creator A5083650412 @default.
• W2135298082 date "2002-04-01" @default.
• W2135298082 modified "2023-10-16" @default.
• W2135298082 title "Free-thiol Cys331 exposed during activation process is critical for native tetramer structure of cathepsin C (dipeptidyl peptidase I)" @default.
• W2135298082 cites W1488196244 @default.
• W2135298082 cites W1508999928 @default.
• W2135298082 cites W1530238672 @default.
• W2135298082 cites W1530246363 @default.
• W2135298082 cites W1547330548 @default.
• W2135298082 cites W1547929361 @default.
• W2135298082 cites W1554921443 @default.
• W2135298082 cites W1563003713 @default.
• W2135298082 cites W1564179195 @default.
• W2135298082 cites W1581767869 @default.
• W2135298082 cites W1592522169 @default.
• W2135298082 cites W1595218069 @default.
• W2135298082 cites W1666826329 @default.
• W2135298082 cites W1721993328 @default.
• W2135298082 cites W1812339273 @default.
• W2135298082 cites W1816126372 @default.
• W2135298082 cites W1845792010 @default.
• W2135298082 cites W1920417980 @default.
• W2135298082 cites W1963587605 @default.
• W2135298082 cites W1970472661 @default.
• W2135298082 cites W1972568444 @default.
• W2135298082 cites W1977989183 @default.
• W2135298082 cites W1988599801 @default.
• W2135298082 cites W1990273557 @default.
• W2135298082 cites W1991032754 @default.
• W2135298082 cites W2001470146 @default.
• W2135298082 cites W2001570021 @default.
• W2135298082 cites W2002126468 @default.
• W2135298082 cites W2016135255 @default.
• W2135298082 cites W2021134612 @default.
• W2135298082 cites W2026014540 @default.
• W2135298082 cites W2026167307 @default.
• W2135298082 cites W2028235694 @default.
• W2135298082 cites W2035163490 @default.
• W2135298082 cites W2035813185 @default.
• W2135298082 cites W2040059111 @default.
• W2135298082 cites W2041673942 @default.
• W2135298082 cites W2049352187 @default.
• W2135298082 cites W2049478555 @default.
• W2135298082 cites W2051156652 @default.
• W2135298082 cites W2066779845 @default.
• W2135298082 cites W2097880240 @default.
• W2135298082 cites W2102923776 @default.
• W2135298082 cites W2122803324 @default.
• W2135298082 cites W2130225747 @default.
• W2135298082 cites W2139074914 @default.
• W2135298082 cites W2151027671 @default.
• W2135298082 cites W2164663952 @default.
• W2135298082 cites W2170872843 @default.
• W2135298082 cites W2322688997 @default.
• W2135298082 cites W2323385545 @default.
• W2135298082 cites W2399880260 @default.
• W2135298082 cites W2404564046 @default.
• W2135298082 cites W2410560887 @default.
• W2135298082 cites W4242796460 @default.
• W2135298082 cites W4246995357 @default.
• W2135298082 doi "https://doi.org/10.1110/ps.2910102" @default.
• W2135298082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2384168" @default.
• W2135298082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11910036" @default.
• W2135298082 hasPublicationYear "2002" @default.
• W2135298082 type Work @default.
• W2135298082 sameAs 2135298082 @default.
• W2135298082 citedByCount "18" @default.
• W2135298082 countsByYear W21352980822012 @default.
• W2135298082 countsByYear W21352980822018 @default.
• W2135298082 countsByYear W21352980822019 @default.
• W2135298082 countsByYear W21352980822022 @default.
• W2135298082 countsByYear W21352980822023 @default.
• W2135298082 crossrefType "journal-article" @default.
• W2135298082 hasAuthorship W2135298082A5002895668 @default.
• W2135298082 hasAuthorship W2135298082A5031295914 @default.
• W2135298082 hasAuthorship W2135298082A5031688867 @default.
• W2135298082 hasAuthorship W2135298082A5043850848 @default.
• W2135298082 hasAuthorship W2135298082A5049132537 @default.
• W2135298082 hasAuthorship W2135298082A5083650412 @default.
• W2135298082 hasBestOaLocation W21352980822 @default.
• W2135298082 hasConcept C145734084 @default.
• W2135298082 hasConcept C167844969 @default.
• W2135298082 hasConcept C178790620 @default.
• W2135298082 hasConcept C179506582 @default.
• W2135298082 hasConcept C181199279 @default.
• W2135298082 hasConcept C185592680 @default.
• W2135298082 hasConcept C2778886173 @default.
• W2135298082 hasConcept C2779201268 @default.
• W2135298082 hasConcept C2779281246 @default.
• W2135298082 hasConcept C2779546866 @default.
• W2135298082 hasConcept C41183919 @default.

• next