Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135320406> ?p ?o ?g. }
- W2135320406 endingPage "1653" @default.
- W2135320406 startingPage "1646" @default.
- W2135320406 abstract "Gestational diabetes (GDM) confers a high risk of type 2 diabetes. In the Diabetes Prevention Program (DPP), intensive lifestyle (ILS) and metformin prevented or delayed diabetes in women with a history of GDM.The objective of the study was to evaluate the impact of ILS and metformin intervention over 10 years in women with and without a history of GDM in the DPP/Diabetes Prevention Program Outcomes Study.This was a randomized controlled clinical trial with an observational follow-up.The study was conducted at 27 clinical centers.Three hundred fifty women with a history of GDM and 1416 women with previous live births but no history of GDM participated in the study. The participants had an elevated body mass index and fasting glucose and impaired glucose tolerance at study entry.Interventions included placebo, ILS, or metformin.Outcomes measure was diabetes mellitus.Over 10 years, women with a history of GDM assigned to placebo had a 48% higher risk of developing diabetes compared with women without a history of GDM. In women with a history of GDM, ILS and metformin reduced progression to diabetes compared with placebo by 35% and 40%, respectively. Among women without a history of GDM, ILS reduced the progression to diabetes by 30%, and metformin did not reduce the progression to diabetes.Women with a history of GDM are at an increased risk of developing diabetes. In women with a history of GDM in the DPP/Diabetes Prevention Program Outcomes Study, both lifestyle and metformin were highly effective in reducing progression to diabetes during a 10-year follow-up period. Among women without a history of GDM, lifestyle but not metformin reduced progression to diabetes." @default.
- W2135320406 created "2016-06-24" @default.
- W2135320406 creator A5005405894 @default.
- W2135320406 creator A5020802111 @default.
- W2135320406 creator A5026841591 @default.
- W2135320406 creator A5034893498 @default.
- W2135320406 creator A5050165878 @default.
- W2135320406 creator A5050501110 @default.
- W2135320406 creator A5057706291 @default.
- W2135320406 creator A5068874080 @default.
- W2135320406 creator A5070846945 @default.
- W2135320406 creator A5081205041 @default.
- W2135320406 creator A5082463316 @default.
- W2135320406 creator A5090320967 @default.
- W2135320406 date "2015-04-01" @default.
- W2135320406 modified "2023-10-18" @default.
- W2135320406 title "The Effect of Lifestyle Intervention and Metformin on Preventing or Delaying Diabetes Among Women With and Without Gestational Diabetes: The Diabetes Prevention Program Outcomes Study 10-Year Follow-Up" @default.
- W2135320406 cites W1511593276 @default.
- W2135320406 cites W1596187835 @default.
- W2135320406 cites W2009658649 @default.
- W2135320406 cites W2021441410 @default.
- W2135320406 cites W2065827854 @default.
- W2135320406 cites W2098558143 @default.
- W2135320406 cites W2138593383 @default.
- W2135320406 cites W2155326729 @default.
- W2135320406 cites W2158822657 @default.
- W2135320406 cites W2166996912 @default.
- W2135320406 cites W2406582234 @default.
- W2135320406 cites W2598089744 @default.
- W2135320406 cites W4233562854 @default.
- W2135320406 doi "https://doi.org/10.1210/jc.2014-3761" @default.
- W2135320406 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4399293" @default.
- W2135320406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25706240" @default.
- W2135320406 hasPublicationYear "2015" @default.
- W2135320406 type Work @default.
- W2135320406 sameAs 2135320406 @default.
- W2135320406 citedByCount "322" @default.
- W2135320406 countsByYear W21353204062015 @default.
- W2135320406 countsByYear W21353204062016 @default.
- W2135320406 countsByYear W21353204062017 @default.
- W2135320406 countsByYear W21353204062018 @default.
- W2135320406 countsByYear W21353204062019 @default.
- W2135320406 countsByYear W21353204062020 @default.
- W2135320406 countsByYear W21353204062021 @default.
- W2135320406 countsByYear W21353204062022 @default.
- W2135320406 countsByYear W21353204062023 @default.
- W2135320406 crossrefType "journal-article" @default.
- W2135320406 hasAuthorship W2135320406A5005405894 @default.
- W2135320406 hasAuthorship W2135320406A5020802111 @default.
- W2135320406 hasAuthorship W2135320406A5026841591 @default.
- W2135320406 hasAuthorship W2135320406A5034893498 @default.
- W2135320406 hasAuthorship W2135320406A5050165878 @default.
- W2135320406 hasAuthorship W2135320406A5050501110 @default.
- W2135320406 hasAuthorship W2135320406A5057706291 @default.
- W2135320406 hasAuthorship W2135320406A5068874080 @default.
- W2135320406 hasAuthorship W2135320406A5070846945 @default.
- W2135320406 hasAuthorship W2135320406A5081205041 @default.
- W2135320406 hasAuthorship W2135320406A5082463316 @default.
- W2135320406 hasAuthorship W2135320406A5090320967 @default.
- W2135320406 hasBestOaLocation W21353204061 @default.
- W2135320406 hasConcept C126322002 @default.
- W2135320406 hasConcept C131872663 @default.
- W2135320406 hasConcept C134018914 @default.
- W2135320406 hasConcept C2777180221 @default.
- W2135320406 hasConcept C2779234561 @default.
- W2135320406 hasConcept C2779434492 @default.
- W2135320406 hasConcept C2780221984 @default.
- W2135320406 hasConcept C2780323712 @default.
- W2135320406 hasConcept C2780609358 @default.
- W2135320406 hasConcept C2781179581 @default.
- W2135320406 hasConcept C46973012 @default.
- W2135320406 hasConcept C54355233 @default.
- W2135320406 hasConcept C555293320 @default.
- W2135320406 hasConcept C71924100 @default.
- W2135320406 hasConcept C86803240 @default.
- W2135320406 hasConceptScore W2135320406C126322002 @default.
- W2135320406 hasConceptScore W2135320406C131872663 @default.
- W2135320406 hasConceptScore W2135320406C134018914 @default.
- W2135320406 hasConceptScore W2135320406C2777180221 @default.
- W2135320406 hasConceptScore W2135320406C2779234561 @default.
- W2135320406 hasConceptScore W2135320406C2779434492 @default.
- W2135320406 hasConceptScore W2135320406C2780221984 @default.
- W2135320406 hasConceptScore W2135320406C2780323712 @default.
- W2135320406 hasConceptScore W2135320406C2780609358 @default.
- W2135320406 hasConceptScore W2135320406C2781179581 @default.
- W2135320406 hasConceptScore W2135320406C46973012 @default.
- W2135320406 hasConceptScore W2135320406C54355233 @default.
- W2135320406 hasConceptScore W2135320406C555293320 @default.
- W2135320406 hasConceptScore W2135320406C71924100 @default.
- W2135320406 hasConceptScore W2135320406C86803240 @default.
- W2135320406 hasIssue "4" @default.
- W2135320406 hasLocation W21353204061 @default.
- W2135320406 hasLocation W21353204062 @default.
- W2135320406 hasLocation W21353204063 @default.
- W2135320406 hasLocation W21353204064 @default.
- W2135320406 hasOpenAccess W2135320406 @default.
- W2135320406 hasPrimaryLocation W21353204061 @default.
- W2135320406 hasRelatedWork W2003238423 @default.