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- W2135340282 endingPage "1372" @default.
- W2135340282 startingPage "1358" @default.
- W2135340282 abstract "Many studies have investigated the systemic and local expression of biomarkers in patients with abdominal aortic aneurysm (AAA). The natural history of AAA varies between patients, and predictors of the presence and diameter of AAA have not been determined consistently. The aim of this study was to perform a systematic review, meta-analysis and meta-regression of studies comparing biomarkers in patients with and without AAA, with the aim of summarizing the association of identified markers with both AAA presence and size.Literature review identified 106 studies suitable for inclusion. Meta-analysis demonstrated a significant difference between matrix metalloproteinase (MMP) 9, tissue inhibitor of matrix metalloproteinase 1, interleukin (IL) 6, C-reactive protein (CRP), α1-antitrypsin, triglycerides, lipoprotein(a), apolipoprotein A and high-density lipoprotein in patients with and without AAA. Although meta-analysis was not possible for MMP-2 in aortic tissue, tumour necrosis factor α, osteoprotegerin, osteopontin, interferon γ, intercellular cell adhesion molecule 1 and vascular cell adhesion molecule 1, systematic review suggested an increase in these biomarkers in patients with AAA. Meta-regression analysis identified a significant positive linear correlation between aortic diameter and CRP level.A wide variety of biomarkers are dysregulated in patients with AAA, but their clinical value is yet to be established. Future research should focus on the most relevant biomarkers of AAA, and how they could be used clinically." @default.
- W2135340282 created "2016-06-24" @default.
- W2135340282 creator A5008821888 @default.
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- W2135340282 creator A5053208782 @default.
- W2135340282 creator A5059881815 @default.
- W2135340282 creator A5067187792 @default.
- W2135340282 date "2014-08-18" @default.
- W2135340282 modified "2023-10-01" @default.
- W2135340282 title "Meta-analysis and meta-regression analysis of biomarkers for abdominal aortic aneurysm" @default.
- W2135340282 cites W1487197110 @default.
- W2135340282 cites W1521091898 @default.
- W2135340282 cites W1571392030 @default.
- W2135340282 cites W1601743618 @default.
- W2135340282 cites W1872370876 @default.
- W2135340282 cites W1876394218 @default.
- W2135340282 cites W1923126167 @default.
- W2135340282 cites W1964027048 @default.
- W2135340282 cites W1967318218 @default.
- W2135340282 cites W1967746541 @default.
- W2135340282 cites W1968126995 @default.
- W2135340282 cites W1970190103 @default.
- W2135340282 cites W1972324190 @default.
- W2135340282 cites W1976096939 @default.
- W2135340282 cites W1976385954 @default.
- W2135340282 cites W1976544507 @default.
- W2135340282 cites W1977015656 @default.
- W2135340282 cites W1980410924 @default.
- W2135340282 cites W1983491250 @default.
- W2135340282 cites W1983678692 @default.
- W2135340282 cites W1984119919 @default.
- W2135340282 cites W1985428638 @default.
- W2135340282 cites W1986340910 @default.
- W2135340282 cites W1986466725 @default.
- W2135340282 cites W1990432418 @default.
- W2135340282 cites W1993721409 @default.
- W2135340282 cites W1996099740 @default.
- W2135340282 cites W1997372590 @default.
- W2135340282 cites W1998731206 @default.
- W2135340282 cites W1999359557 @default.
- W2135340282 cites W1999707847 @default.
- W2135340282 cites W2005053505 @default.
- W2135340282 cites W2005628815 @default.
- W2135340282 cites W2005829453 @default.
- W2135340282 cites W2005910498 @default.
- W2135340282 cites W2006236226 @default.
- W2135340282 cites W2006578354 @default.
- W2135340282 cites W2006935887 @default.
- W2135340282 cites W2007474036 @default.
- W2135340282 cites W2007872832 @default.
- W2135340282 cites W2008856541 @default.
- W2135340282 cites W2010606017 @default.
- W2135340282 cites W2011441790 @default.
- W2135340282 cites W2015156312 @default.
- W2135340282 cites W2015354488 @default.
- W2135340282 cites W2016964117 @default.
- W2135340282 cites W2018904798 @default.
- W2135340282 cites W2019046902 @default.
- W2135340282 cites W2019782788 @default.
- W2135340282 cites W2021423429 @default.
- W2135340282 cites W2024124690 @default.
- W2135340282 cites W2038821948 @default.
- W2135340282 cites W2041199485 @default.
- W2135340282 cites W2041817146 @default.
- W2135340282 cites W2043002844 @default.
- W2135340282 cites W2045050223 @default.
- W2135340282 cites W2046487113 @default.
- W2135340282 cites W2047552631 @default.
- W2135340282 cites W2051715752 @default.
- W2135340282 cites W2054656873 @default.
- W2135340282 cites W2059570306 @default.
- W2135340282 cites W2063699934 @default.
- W2135340282 cites W2065556887 @default.
- W2135340282 cites W2068931939 @default.
- W2135340282 cites W2071286923 @default.
- W2135340282 cites W2074304438 @default.
- W2135340282 cites W2075377475 @default.
- W2135340282 cites W2076314183 @default.
- W2135340282 cites W2076749881 @default.
- W2135340282 cites W2077576279 @default.
- W2135340282 cites W2080014204 @default.
- W2135340282 cites W2080806988 @default.
- W2135340282 cites W2081011908 @default.
- W2135340282 cites W2081928151 @default.
- W2135340282 cites W2084838040 @default.
- W2135340282 cites W2088142457 @default.
- W2135340282 cites W2092056011 @default.
- W2135340282 cites W2093066281 @default.
- W2135340282 cites W2097514958 @default.
- W2135340282 cites W2104881638 @default.
- W2135340282 cites W2106967153 @default.
- W2135340282 cites W2116581335 @default.
- W2135340282 cites W2118967036 @default.
- W2135340282 cites W2119292444 @default.
- W2135340282 cites W2119990476 @default.
- W2135340282 cites W2122849332 @default.