Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135352311> ?p ?o ?g. }
- W2135352311 endingPage "25" @default.
- W2135352311 startingPage "12" @default.
- W2135352311 abstract "Chronic myeloproliferative disorders (CMPD) are clonal disorders of the hematopoietic stem cell. The myeloid lineage shows increased proliferation with effective maturation, while peripheral leukocytosis, thrombocytosis or elevated red blood cell mass are found. In Philadelphia negative CMPD recurrent cytogenetic abnormalities occur, but no specific abnormality has been defined to date. The spectrum of cytogenetic aberrations is heterogeneous ranging from numerical gains and losses to structural changes including unbalanced translocations. The most common chromosomal abnormalities are 20q-, 13q-, 12p-, +8, +9, partial duplication of 1q, balanced translocations involving 8p11 and gains in 9p. Cytogenetic analysis of CMPD by conventional or molecular techniques has an important role in establishing the diagnosis of a malignant disease, adding also more information for disease outcome. Molecular studies may detect the possible role of candidate genes implicated in the neoplastic process, addressing new molecular target therapies. FIP1L1/PDGFRalpha rearrangements, as well as alterations of PDGFRbeta or FGFR1 gene have been found to be associated with specific types of CMPD. Recently, a novel somatic mutation, JAK2V617F, has been reported in most of the polycthemia vera (PV) patients, as well as in a lower percentage in essential thrombocythemia (ET) or idiopathic myelofibrosis (IMF) patients. This finding represents the most important advance in understanding of the molecular mechanisms underlined the pathogenesis of CMPD, contributing to the classification and management of patients." @default.
- W2135352311 created "2016-06-24" @default.
- W2135352311 creator A5086846525 @default.
- W2135352311 date "2007-09-01" @default.
- W2135352311 modified "2023-09-26" @default.
- W2135352311 title "Cytogenetic and molecular aspects of Philadelphia negative chronic myeloproliferative disorders: Clinical implications" @default.
- W2135352311 cites W11426206 @default.
- W2135352311 cites W11727989 @default.
- W2135352311 cites W134398319 @default.
- W2135352311 cites W1421162947 @default.
- W2135352311 cites W1498616452 @default.
- W2135352311 cites W1538098067 @default.
- W2135352311 cites W1964323527 @default.
- W2135352311 cites W1965007670 @default.
- W2135352311 cites W1969928032 @default.
- W2135352311 cites W1971855003 @default.
- W2135352311 cites W1979140248 @default.
- W2135352311 cites W1980464575 @default.
- W2135352311 cites W1980568348 @default.
- W2135352311 cites W1980640262 @default.
- W2135352311 cites W1980743356 @default.
- W2135352311 cites W1981240373 @default.
- W2135352311 cites W1989571633 @default.
- W2135352311 cites W1991088396 @default.
- W2135352311 cites W1993793998 @default.
- W2135352311 cites W1994078715 @default.
- W2135352311 cites W1996502308 @default.
- W2135352311 cites W1999608888 @default.
- W2135352311 cites W2000055313 @default.
- W2135352311 cites W2000310662 @default.
- W2135352311 cites W2000856791 @default.
- W2135352311 cites W2001432071 @default.
- W2135352311 cites W2003269232 @default.
- W2135352311 cites W2004197291 @default.
- W2135352311 cites W2005618931 @default.
- W2135352311 cites W2005831731 @default.
- W2135352311 cites W2007237117 @default.
- W2135352311 cites W2007837914 @default.
- W2135352311 cites W2007970476 @default.
- W2135352311 cites W2009018655 @default.
- W2135352311 cites W2009288532 @default.
- W2135352311 cites W2009551392 @default.
- W2135352311 cites W2009883322 @default.
- W2135352311 cites W2012952884 @default.
- W2135352311 cites W2016396075 @default.
- W2135352311 cites W2017410022 @default.
- W2135352311 cites W2018618600 @default.
- W2135352311 cites W2019002662 @default.
- W2135352311 cites W2019247681 @default.
- W2135352311 cites W2022159066 @default.
- W2135352311 cites W2022930434 @default.
- W2135352311 cites W2022939548 @default.
- W2135352311 cites W2025606645 @default.
- W2135352311 cites W2029923373 @default.
- W2135352311 cites W2030358773 @default.
- W2135352311 cites W2030455762 @default.
- W2135352311 cites W2031452702 @default.
- W2135352311 cites W2036180570 @default.
- W2135352311 cites W2041062474 @default.
- W2135352311 cites W2043314058 @default.
- W2135352311 cites W2049145190 @default.
- W2135352311 cites W2049690725 @default.
- W2135352311 cites W2050447147 @default.
- W2135352311 cites W2053378794 @default.
- W2135352311 cites W2053690380 @default.
- W2135352311 cites W2056116861 @default.
- W2135352311 cites W2057360098 @default.
- W2135352311 cites W2059555015 @default.
- W2135352311 cites W2059675876 @default.
- W2135352311 cites W2061956129 @default.
- W2135352311 cites W2067163246 @default.
- W2135352311 cites W2068680704 @default.
- W2135352311 cites W2071955170 @default.
- W2135352311 cites W2073653195 @default.
- W2135352311 cites W2074646304 @default.
- W2135352311 cites W2076569573 @default.
- W2135352311 cites W2076770247 @default.
- W2135352311 cites W2077788896 @default.
- W2135352311 cites W2077816916 @default.
- W2135352311 cites W2079538300 @default.
- W2135352311 cites W2082219570 @default.
- W2135352311 cites W2083373602 @default.
- W2135352311 cites W2085619564 @default.
- W2135352311 cites W2085920715 @default.
- W2135352311 cites W2086939138 @default.
- W2135352311 cites W2090450792 @default.
- W2135352311 cites W2093290834 @default.
- W2135352311 cites W2094457899 @default.
- W2135352311 cites W2096638244 @default.
- W2135352311 cites W2097359805 @default.
- W2135352311 cites W2097840856 @default.
- W2135352311 cites W2101502003 @default.
- W2135352311 cites W2101998843 @default.
- W2135352311 cites W2105949419 @default.
- W2135352311 cites W2113793740 @default.
- W2135352311 cites W2117360756 @default.
- W2135352311 cites W2121181977 @default.
- W2135352311 cites W2121458987 @default.