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- W2135352714 abstract "To the Editor: Recently, there has been an increasing interest in the immunomodulatory effects of vitamin D. Several studies have suggested detrimental effects of insufficient 25-hydroxyvitamin D (25(OH)D) levels on the innate and acquired immune system, which may contribute to the development of infections and atopic and allergic conditions [1–4]. Children and pregnant and lactating females have been identified as groups with a high risk of 25(OH)D insufficiency [5]. Low maternal serum 25(OH)D levels in pregnancy may contribute to increased risk of infections and atopic outcomes in offspring. Previous studies demonstrate inconsistency regarding relationships between maternal vitamin D intake, serum 25(OH)D levels and umbilical cord 25(OH)D levels with these outcomes in offspring [6–10]. We aimed to explore relationships between maternal serum 25(OH)D levels during late pregnancy and parent-reported respiratory tract symptoms and doctor-diagnosed lower respiratory tract infections (LRTI) in early childhood in a large cohort study.The study sample consisted of 2025 mother–child pairs from the Southampton Women’s Survey with maternal serum 25(OH)D …" @default.
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- W2135352714 date "2013-12-12" @default.
- W2135352714 modified "2023-10-17" @default.
- W2135352714 title "Maternal 25-hydroxyvitamin D levels in relation to offspring respiratory symptoms and infections" @default.
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- W2135352714 doi "https://doi.org/10.1183/09031936.00116913" @default.
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