FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135354503> ?p ?o ?g. }

• W2135354503 endingPage "233" @default.
• W2135354503 startingPage "233" @default.
• W2135354503 abstract "Background: It is not known whether rigorous intraoperative glycemic control reduces death and morbidity in cardiac surgery patients. Objective: To compare outcomes of intensive insulin therapy during cardiac surgery with those of conventional intraoperative glucose management. Design: A randomized, open-label, controlled trial with blinded end point assessment. Setting: Tertiary care center. Patients: Adults with and without diabetes who were undergoing on-pump cardiac surgery. Measurements: The primary outcome was a composite of death, sternal infections, prolonged ventilation, cardiac arrhythmias, stroke, and renal failure within 30 days after surgery. Secondary outcome measures were length of stay in the intensive care unit and hospital. Intervention: Patients were randomly assigned to receive continuous insulin infusion to maintain intraoperative glucose levels between 4.4 (80 mg/dL) and 5.6 mmol/L (100 mg/dL) (n = 199) or conventional treatment (n = 201). Patients in the conventional treatment group were not given insulin during surgery unless glucose levels were greater than 11.1 mmol/L (>200 mg/dL). Both groups were treated with insulin infusion to maintain normoglycemia after surgery. Results: Mean glucose concentrations were statistically significantly lower in the intensive treatment group at the end of surgery (6.3 mmol/L [SD, 1.6] [114 mg/dL {SD, 29}] in the intensive treatment group vs. 8.7 mmol/L [SD, 2.3] [157 mg/dL {SD, 42}] in the conventional treatment group; difference, −2.4 mmol/L [95% CI, −2.8 to −1.9 mmol/L] [−43 mg/dL {CI, −50 to −35 mg/dL}]). Eighty two of 185 patients (44%) in the intensive treatment group and 86 of 186 patients (46%) in the conventional treatment group had an event (risk ratio, 1.0 [CI, 0.8 to 1.2]). More deaths (4 deaths vs. 0 deaths; P = 0.061) and strokes (8 strokes vs. 1 strokes; P = 0.020) occurred in the intensive treatment group. Length of stay in the intensive care unit (mean, 2 days [SD, 2] vs. 2 days [SD, 3]; difference, 0 days [CI, −1 to 1 days]) and in the hospital (mean, 8 days [SD, 4] vs. 8 days [SD, 5]; difference, 0 days [CI, −1 to 0 days]) was similar for both groups. Limitations: This single-center study used a composite end point and could not examine whether outcomes differed by diabetes status. Conclusions: Intensive insulin therapy during cardiac surgery does not reduce perioperative death or morbidity. The increased incidence of death and stroke in the intensive treatment group raises concern about routine implementation of this intervention." @default.
• W2135354503 created "2016-06-24" @default.
• W2135354503 creator A5005889308 @default.
• W2135354503 creator A5008947273 @default.
• W2135354503 creator A5024077089 @default.
• W2135354503 creator A5039343396 @default.
• W2135354503 creator A5041667329 @default.
• W2135354503 creator A5047433990 @default.
• W2135354503 creator A5048280596 @default.
• W2135354503 creator A5053849505 @default.
• W2135354503 creator A5069319732 @default.
• W2135354503 creator A5073547744 @default.
• W2135354503 creator A5077000585 @default.
• W2135354503 creator A5091900520 @default.
• W2135354503 date "2007-02-20" @default.
• W2135354503 modified "2023-10-17" @default.
• W2135354503 title "Intensive Intraoperative Insulin Therapy versus Conventional Glucose Management during Cardiac Surgery" @default.
• W2135354503 cites W1607440587 @default.
• W2135354503 cites W1946033027 @default.
• W2135354503 cites W1969128977 @default.
• W2135354503 cites W1980717583 @default.
• W2135354503 cites W1983681292 @default.
• W2135354503 cites W1988221993 @default.
• W2135354503 cites W1993131507 @default.
• W2135354503 cites W2008545806 @default.
• W2135354503 cites W2009649501 @default.
• W2135354503 cites W2010346254 @default.
• W2135354503 cites W2012633396 @default.
• W2135354503 cites W2022530282 @default.
• W2135354503 cites W2035882325 @default.
• W2135354503 cites W2059707463 @default.
• W2135354503 cites W2074300019 @default.
• W2135354503 cites W2074745934 @default.
• W2135354503 cites W2076780152 @default.
• W2135354503 cites W2092173577 @default.
• W2135354503 cites W2092998122 @default.
• W2135354503 cites W2103861354 @default.
• W2135354503 cites W2136068942 @default.
• W2135354503 cites W2142226947 @default.
• W2135354503 cites W2169968309 @default.
• W2135354503 cites W3150387692 @default.
• W2135354503 cites W97942520 @default.
• W2135354503 doi "https://doi.org/10.7326/0003-4819-146-4-200702200-00002" @default.
• W2135354503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17310047" @default.
• W2135354503 hasPublicationYear "2007" @default.
• W2135354503 type Work @default.
• W2135354503 sameAs 2135354503 @default.
• W2135354503 citedByCount "550" @default.
• W2135354503 countsByYear W21353545032012 @default.
• W2135354503 countsByYear W21353545032013 @default.
• W2135354503 countsByYear W21353545032014 @default.
• W2135354503 countsByYear W21353545032015 @default.
• W2135354503 countsByYear W21353545032016 @default.
• W2135354503 countsByYear W21353545032017 @default.
• W2135354503 countsByYear W21353545032018 @default.
• W2135354503 countsByYear W21353545032019 @default.
• W2135354503 countsByYear W21353545032020 @default.
• W2135354503 countsByYear W21353545032021 @default.
• W2135354503 countsByYear W21353545032022 @default.
• W2135354503 countsByYear W21353545032023 @default.
• W2135354503 crossrefType "journal-article" @default.
• W2135354503 hasAuthorship W2135354503A5005889308 @default.
• W2135354503 hasAuthorship W2135354503A5008947273 @default.
• W2135354503 hasAuthorship W2135354503A5024077089 @default.
• W2135354503 hasAuthorship W2135354503A5039343396 @default.
• W2135354503 hasAuthorship W2135354503A5041667329 @default.
• W2135354503 hasAuthorship W2135354503A5047433990 @default.
• W2135354503 hasAuthorship W2135354503A5048280596 @default.
• W2135354503 hasAuthorship W2135354503A5053849505 @default.
• W2135354503 hasAuthorship W2135354503A5069319732 @default.
• W2135354503 hasAuthorship W2135354503A5073547744 @default.
• W2135354503 hasAuthorship W2135354503A5077000585 @default.
• W2135354503 hasAuthorship W2135354503A5091900520 @default.
• W2135354503 hasConcept C126322002 @default.
• W2135354503 hasConcept C134018914 @default.
• W2135354503 hasConcept C141071460 @default.
• W2135354503 hasConcept C168563851 @default.
• W2135354503 hasConcept C177713679 @default.
• W2135354503 hasConcept C2776376669 @default.
• W2135354503 hasConcept C2778789114 @default.
• W2135354503 hasConcept C2779306644 @default.
• W2135354503 hasConcept C2780473172 @default.
• W2135354503 hasConcept C2987404301 @default.
• W2135354503 hasConcept C42219234 @default.
• W2135354503 hasConcept C555293320 @default.
• W2135354503 hasConcept C71924100 @default.
• W2135354503 hasConceptScore W2135354503C126322002 @default.
• W2135354503 hasConceptScore W2135354503C134018914 @default.
• W2135354503 hasConceptScore W2135354503C141071460 @default.
• W2135354503 hasConceptScore W2135354503C168563851 @default.
• W2135354503 hasConceptScore W2135354503C177713679 @default.
• W2135354503 hasConceptScore W2135354503C2776376669 @default.
• W2135354503 hasConceptScore W2135354503C2778789114 @default.
• W2135354503 hasConceptScore W2135354503C2779306644 @default.
• W2135354503 hasConceptScore W2135354503C2780473172 @default.
• W2135354503 hasConceptScore W2135354503C2987404301 @default.
• W2135354503 hasConceptScore W2135354503C42219234 @default.
• W2135354503 hasConceptScore W2135354503C555293320 @default.

• next