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• W2135356618 abstract "We have investigated the role of adenosine and its analogs on vasorelaxation of mouse aorta in intact endothelium with rank order of potency as follows: 5′- N-ethylcarboxamidoadenosine (NECA) > 2-chloroadenosine > adenosine ≫ CGS-21680, which is consistent with the profile of A 2B -adenosine receptor (A 2B AR). In endothelium-intact tissues, acetylcholine produced relaxation ranging from 65 to 80% in phenylephrine (PE, 10 −7 M)-precontracted mouse aorta, whereas no relaxation was observed in endothelium-denuded tissues. The A 2B AR antagonist alloxazine (10 −5 M) shifted concentration-response curve for NECA (EC 50 = 0.005 × 10 −5 M) to the right with an EC 50 of 2.8 × 10 −5 M, demonstrating that this relaxation is partially dependent on functional endothelium mediated predominantly via A 2B AR in this tissue. This conclusion was further supported by the following findings: 1) in the endothelium-intact mouse aorta, the EC 50 values for NECA and adenosine were found to be 0.05 and 1.99 × 10 −4 M, respectively; however, in denuded endothelium, these values were 0.098 and 3.55 × 10 −4 M, respectively; 2) NECA-induced relaxation was significantly blocked by N G -nitro-l-arginine methyl ester (l-NAME; 10 −4 M) in endothelium-intact tissues, which was reversed by pretreatment with l-arginine (10 −4 M), whereas no significant inhibition was found in endothelium-denuded tissues; 3) total nitrites and nitrates (NOx) in intact endothelium with l-NAME (10 −4 M) alone and in combination with l-arginine were 59% ( P < 0.05) and 96%, respectively, in comparison with control (PE + NECA); and 4) endothelial nitric oxide synthase gene expression was found to be 67% ( P < 0.05) less in endothelium-denuded as opposed to endothelium-intact mouse aorta. Thus these data demonstrate that adenosine-mediated vasorelaxation is partially dependent on A 2B AR in mouse aorta." @default.
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• W2135356618 date "2007-01-01" @default.
• W2135356618 modified "2023-10-09" @default.
• W2135356618 title "Evidence for the involvement of nitric oxide in A_2B receptor-mediated vasorelaxation of mouse aorta" @default.
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• W2135356618 doi "https://doi.org/10.1152/ajpheart.00593.2006" @default.
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