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- W2135359579 abstract "Significance High-mobility group box (HMGB)1 is a nuclear protein that we have identified as a proinflammatory mediator during infection or sterile tissue injury, which importantly orchestrates the innate immune responses. The mechanisms of HMGB1 release require translocation of HMGB1 from nucleus to cytoplasm and release into the extracellular space. We recently reported that the inflammasome and PKR mediates HMGB1 release from the cytoplasm, but the mechanism of HMGB1 translocation from nucleus to cytoplasm was previously unknown. Here, we describe our discovery that JAK/STAT1 is required for LPS- or interferon-induced HMGB1 nuclear translocation. These findings have significant implications for the field, and for designing therapeutics for potential use in inflammatory diseases." @default.
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- W2135359579 date "2014-01-27" @default.
- W2135359579 modified "2023-10-18" @default.
- W2135359579 title "JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation" @default.
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- W2135359579 doi "https://doi.org/10.1073/pnas.1316925111" @default.
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