FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135363003> ?p ?o ?g. }

• W2135363003 endingPage "3839" @default.
• W2135363003 startingPage "3830" @default.
• W2135363003 abstract "Polypurine tracts are important elements of eukaryotic promoters. They are believed to somehow destabilize chromatin, but the mechanism of their action is not known. We show that incorporating an A(16) element at an end of the nucleosomal DNA and further inward destabilizes histone-DNA interactions by 0.1 +/- 0.03 and 0.35 +/- 0.04 kcal mol(-1), respectively, and is accompanied by 1.5- +/- 0.1-fold and 1.7- +/- 0.1-fold increases in position-averaged equilibrium accessibility of nucleosomal DNA target sites. These effects are comparable in magnitude to effects of A(16) elements that correlate with transcription in vivo, suggesting that our system may capture most of their physiological role. These results point to two distinct but interrelated models for the mechanism of action of polypurine tract promoter elements in vivo. Given a nucleosome positioned over a promoter region, the presence of a polypurine tract in that nucleosome's DNA decreases the stability of the DNA wrapping, increasing the equilibrium accessibility of other DNA target sites buried inside that nucleosome. Alternatively (if nucleosomes are freely mobile), the presence of a polypurine tract provides a free energy bias for the nucleosome to move to alternative locations, thereby changing the equilibrium accessibilities of other nearby DNA target sites." @default.
• W2135363003 created "2016-06-24" @default.
• W2135363003 creator A5012792912 @default.
• W2135363003 creator A5049261473 @default.
• W2135363003 date "2001-06-01" @default.
• W2135363003 modified "2023-10-15" @default.
• W2135363003 title "Poly(dA-dT) Promoter Elements Increase the Equilibrium Accessibility of Nucleosomal DNA Target Sites" @default.
• W2135363003 cites W1481242698 @default.
• W2135363003 cites W1520588455 @default.
• W2135363003 cites W1564217760 @default.
• W2135363003 cites W1963611529 @default.
• W2135363003 cites W1968750269 @default.
• W2135363003 cites W1968864409 @default.
• W2135363003 cites W1978569157 @default.
• W2135363003 cites W1981585431 @default.
• W2135363003 cites W1984762771 @default.
• W2135363003 cites W1985189558 @default.
• W2135363003 cites W1985460850 @default.
• W2135363003 cites W1988997227 @default.
• W2135363003 cites W1992243707 @default.
• W2135363003 cites W1994064477 @default.
• W2135363003 cites W1998376385 @default.
• W2135363003 cites W2014872506 @default.
• W2135363003 cites W2015472477 @default.
• W2135363003 cites W2017141862 @default.
• W2135363003 cites W2026368142 @default.
• W2135363003 cites W2028895538 @default.
• W2135363003 cites W2029437998 @default.
• W2135363003 cites W2033072260 @default.
• W2135363003 cites W2038645974 @default.
• W2135363003 cites W2044495919 @default.
• W2135363003 cites W2049722408 @default.
• W2135363003 cites W2050042672 @default.
• W2135363003 cites W2053897628 @default.
• W2135363003 cites W2054089388 @default.
• W2135363003 cites W2066204517 @default.
• W2135363003 cites W2078021166 @default.
• W2135363003 cites W2079162626 @default.
• W2135363003 cites W2079524506 @default.
• W2135363003 cites W2080139629 @default.
• W2135363003 cites W2083329762 @default.
• W2135363003 cites W2089741745 @default.
• W2135363003 cites W2094588941 @default.
• W2135363003 cites W2129314778 @default.
• W2135363003 cites W2152406248 @default.
• W2135363003 cites W2154192967 @default.
• W2135363003 cites W236239785 @default.
• W2135363003 doi "https://doi.org/10.1128/mcb.21.11.3830-3839.2001" @default.
• W2135363003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/87046" @default.
• W2135363003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11340174" @default.
• W2135363003 hasPublicationYear "2001" @default.
• W2135363003 type Work @default.
• W2135363003 sameAs 2135363003 @default.
• W2135363003 citedByCount "148" @default.
• W2135363003 countsByYear W21353630032012 @default.
• W2135363003 countsByYear W21353630032013 @default.
• W2135363003 countsByYear W21353630032014 @default.
• W2135363003 countsByYear W21353630032015 @default.
• W2135363003 countsByYear W21353630032016 @default.
• W2135363003 countsByYear W21353630032017 @default.
• W2135363003 countsByYear W21353630032018 @default.
• W2135363003 countsByYear W21353630032019 @default.
• W2135363003 countsByYear W21353630032020 @default.
• W2135363003 countsByYear W21353630032021 @default.
• W2135363003 countsByYear W21353630032022 @default.
• W2135363003 countsByYear W21353630032023 @default.
• W2135363003 crossrefType "journal-article" @default.
• W2135363003 hasAuthorship W2135363003A5012792912 @default.
• W2135363003 hasAuthorship W2135363003A5049261473 @default.
• W2135363003 hasBestOaLocation W21353630031 @default.
• W2135363003 hasConcept C101762097 @default.
• W2135363003 hasConcept C104317684 @default.
• W2135363003 hasConcept C12554922 @default.
• W2135363003 hasConcept C138885662 @default.
• W2135363003 hasConcept C150194340 @default.
• W2135363003 hasConcept C179926584 @default.
• W2135363003 hasConcept C195856716 @default.
• W2135363003 hasConcept C22744801 @default.
• W2135363003 hasConcept C41895202 @default.
• W2135363003 hasConcept C54355233 @default.
• W2135363003 hasConcept C552990157 @default.
• W2135363003 hasConcept C64927066 @default.
• W2135363003 hasConcept C83640560 @default.
• W2135363003 hasConcept C84772758 @default.
• W2135363003 hasConcept C86803240 @default.
• W2135363003 hasConceptScore W2135363003C101762097 @default.
• W2135363003 hasConceptScore W2135363003C104317684 @default.
• W2135363003 hasConceptScore W2135363003C12554922 @default.
• W2135363003 hasConceptScore W2135363003C138885662 @default.
• W2135363003 hasConceptScore W2135363003C150194340 @default.
• W2135363003 hasConceptScore W2135363003C179926584 @default.
• W2135363003 hasConceptScore W2135363003C195856716 @default.
• W2135363003 hasConceptScore W2135363003C22744801 @default.
• W2135363003 hasConceptScore W2135363003C41895202 @default.
• W2135363003 hasConceptScore W2135363003C54355233 @default.
• W2135363003 hasConceptScore W2135363003C552990157 @default.
• W2135363003 hasConceptScore W2135363003C64927066 @default.
• W2135363003 hasConceptScore W2135363003C83640560 @default.

• next