FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135364785> ?p ?o ?g. }

• W2135364785 endingPage "1408" @default.
• W2135364785 startingPage "1397" @default.
• W2135364785 abstract "The human mast cell line (HMC-1) has been used to study the relationship between intracellular pH and cytosolic calcium (Ca2+) in mast cells. Thapsigargin (TG) caused store-operated Ca2+ entry, that is enhanced by the PKC activator PMA. NH4Cl-induced alkalinization showed an inhibitory effect on TG-sensitive stores depletion (not on TG-insensitive stores), and also on final cytosolic Ca2+ levels reached in response to both TG and the ionophore ionomycin. Loperamide, a positive modulator of store-operated channels, induced a slight Ca2+ entry by itself, and also increased TG-induced Ca2+ entry. This enhancement was not enough to reverse the inhibitory effect of NH4Cl-induced alkalinization. When comparing the effect of NH4Cl-induced alkalinization on Ca2+ levels, with those observed using Ca2+ channel blockers (namely Ni2+ and SKF-96365), cytosolic profiles for this ion are different, either in modified saline solution or in HCO3(-)-free medium. Thus, it seems unlikely that the inhibitory effect of NH4Cl-induced alkalinization on Ca2+ is taking place by blockage of Ca2+ entry. Furthermore, inhibition of the plasma membrane Ca2+-ATPase (an important mechanism for Ca2+ efflux) with sodium orthovanadate (SO) matches with the inhibition of the negative effect on Ca2+ levels elicited by NH4Cl. Data indicate that NH4Cl-induced alkalinization might be activating Ca2+ efflux from the cell, by stimulation of the plasma membrane Ca2+-ATPase, and also confirm our previous finding that Ca2+ is a secondary signal to activate HMC-1 cells." @default.
• W2135364785 created "2016-06-24" @default.
• W2135364785 creator A5018136936 @default.
• W2135364785 creator A5043992692 @default.
• W2135364785 creator A5046566274 @default.
• W2135364785 creator A5051937379 @default.
• W2135364785 creator A5077293613 @default.
• W2135364785 creator A5086153083 @default.
• W2135364785 creator A5089682600 @default.
• W2135364785 date "2006-06-30" @default.
• W2135364785 modified "2023-10-10" @default.
• W2135364785 title "Calcium-pH Crosstalks in the human mast cell line HMC-1: Intracellular alkalinization activates calcium extrusion through the plasma membrane Ca2+-ATPase" @default.
• W2135364785 cites W1529543283 @default.
• W2135364785 cites W1549402528 @default.
• W2135364785 cites W1587223545 @default.
• W2135364785 cites W1894541516 @default.
• W2135364785 cites W1953311373 @default.
• W2135364785 cites W195911157 @default.
• W2135364785 cites W1965148755 @default.
• W2135364785 cites W1966106073 @default.
• W2135364785 cites W1970241582 @default.
• W2135364785 cites W1980340016 @default.
• W2135364785 cites W1984974974 @default.
• W2135364785 cites W1986585141 @default.
• W2135364785 cites W1987432820 @default.
• W2135364785 cites W1995063959 @default.
• W2135364785 cites W2000072733 @default.
• W2135364785 cites W2007742656 @default.
• W2135364785 cites W2011868510 @default.
• W2135364785 cites W2015480034 @default.
• W2135364785 cites W2020206059 @default.
• W2135364785 cites W2022236617 @default.
• W2135364785 cites W2033936610 @default.
• W2135364785 cites W2039176794 @default.
• W2135364785 cites W2044309378 @default.
• W2135364785 cites W2045987871 @default.
• W2135364785 cites W2046763191 @default.
• W2135364785 cites W2050713682 @default.
• W2135364785 cites W2052365101 @default.
• W2135364785 cites W2059747916 @default.
• W2135364785 cites W2060915169 @default.
• W2135364785 cites W2063965075 @default.
• W2135364785 cites W2066875720 @default.
• W2135364785 cites W2073622649 @default.
• W2135364785 cites W2074422781 @default.
• W2135364785 cites W2080804850 @default.
• W2135364785 cites W2085949705 @default.
• W2135364785 cites W2086715679 @default.
• W2135364785 cites W2087636168 @default.
• W2135364785 cites W2102864068 @default.
• W2135364785 cites W2114305100 @default.
• W2135364785 cites W2122012166 @default.
• W2135364785 cites W2141260882 @default.
• W2135364785 cites W2161273989 @default.
• W2135364785 cites W2164229065 @default.
• W2135364785 cites W2165871503 @default.
• W2135364785 cites W2195148422 @default.
• W2135364785 cites W2331001979 @default.
• W2135364785 cites W2416877264 @default.
• W2135364785 cites W2073908438 @default.
• W2135364785 doi "https://doi.org/10.1002/jcb.21010" @default.
• W2135364785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16817237" @default.
• W2135364785 hasPublicationYear "2006" @default.
• W2135364785 type Work @default.
• W2135364785 sameAs 2135364785 @default.
• W2135364785 citedByCount "6" @default.
• W2135364785 countsByYear W21353647852018 @default.
• W2135364785 countsByYear W21353647852019 @default.
• W2135364785 crossrefType "journal-article" @default.
• W2135364785 hasAuthorship W2135364785A5018136936 @default.
• W2135364785 hasAuthorship W2135364785A5043992692 @default.
• W2135364785 hasAuthorship W2135364785A5046566274 @default.
• W2135364785 hasAuthorship W2135364785A5051937379 @default.
• W2135364785 hasAuthorship W2135364785A5077293613 @default.
• W2135364785 hasAuthorship W2135364785A5086153083 @default.
• W2135364785 hasAuthorship W2135364785A5089682600 @default.
• W2135364785 hasConcept C12554922 @default.
• W2135364785 hasConcept C178790620 @default.
• W2135364785 hasConcept C181080969 @default.
• W2135364785 hasConcept C181199279 @default.
• W2135364785 hasConcept C185592680 @default.
• W2135364785 hasConcept C203014093 @default.
• W2135364785 hasConcept C2776989580 @default.
• W2135364785 hasConcept C2777146706 @default.
• W2135364785 hasConcept C2778470358 @default.
• W2135364785 hasConcept C2779726688 @default.
• W2135364785 hasConcept C28406088 @default.
• W2135364785 hasConcept C519063684 @default.
• W2135364785 hasConcept C55493867 @default.
• W2135364785 hasConcept C79879829 @default.
• W2135364785 hasConcept C86803240 @default.
• W2135364785 hasConcept C98539663 @default.
• W2135364785 hasConceptScore W2135364785C12554922 @default.
• W2135364785 hasConceptScore W2135364785C178790620 @default.
• W2135364785 hasConceptScore W2135364785C181080969 @default.
• W2135364785 hasConceptScore W2135364785C181199279 @default.
• W2135364785 hasConceptScore W2135364785C185592680 @default.
• W2135364785 hasConceptScore W2135364785C203014093 @default.

• next