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• W2135365013 startingPage "42" @default.
• W2135365013 abstract "To allow DNA replication only once per cell cycle, origins of replication are reactivated ('licensed') during each G1 phase. Licensing is facilitated by assembly of the pre-replicative complex (pre-RC) at origins that concludes with loading the mini-chromosome maintenance (MCM) complex onto chromatin. Here we show that a virus exploits pre-RC assembly to selectively inhibit cellular DNA replication. Infection of quiescent primary fibroblasts with human cytomegalovirus (HCMV) induces all pre-RC factors. Although this is sufficient to assemble the MCM-loading factors onto chromatin, as it is in serum-stimulated cells, the virus inhibits loading of the MCM complex itself, thereby prematurely abrogating replication licensing. This provides a new level of control in pre-RC assembly and a mechanistic rationale for the unusual HCMV-induced G1 arrest that occurs despite the activation of the cyclin E-dependent transcription programme. Thus, this particularly large virus might thereby secure the supply with essential replication factors but omit competitive cellular DNA replication." @default.
• W2135365013 created "2016-06-24" @default.
• W2135365013 creator A5028490090 @default.
• W2135365013 creator A5039907115 @default.
• W2135365013 creator A5063858118 @default.
• W2135365013 date "2003-01-01" @default.
• W2135365013 modified "2023-10-16" @default.
• W2135365013 title "Human cytomegalovirus prevents replication licensing by inhibiting MCM loading onto chromatin" @default.
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• W2135365013 doi "https://doi.org/10.1038/sj.embor.embor707" @default.
• W2135365013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1315807" @default.
• W2135365013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12524519" @default.
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