Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135366903> ?p ?o ?g. }
- W2135366903 endingPage "655" @default.
- W2135366903 startingPage "645" @default.
- W2135366903 abstract "In recent years several reports have claimed to demonstrate trans-differentiation, namely that stem cells have been derived from a given tissue and have differentiated into phenotypes characteristic of different tissues following transplantation or in vitro treatment. For example, the mesenchymal stem cells, also referred to as marrow stromal stem cells (MSCs), present in bone marrow, have been induced to differentiate into neurons. We decided to investigate this phenomenon more in depth by a molecular and morphological follow-up. We analyzed the biochemical pathways that are currently induced to trigger neuron-like commitment and maturation of MSCs. Our studies suggest that: (i) the increase in cAMP, induced to differentiate MSCs, activates the classical PKA pathway and not through the exchange protein directly activated by cAMP (EPAC), a guanine nucleotide exchange factor for the small GTPase Rap1 and Rap2; (ii) MEK-ERK signaling could contribute to neural commitment and differentiation; (iii) CaM KII activity seems dispensable for neuron differentiation. On the contrary, its inhibition could contribute to rescuing differentiating cells from death. Our research also indicates that the currently used in vitro differentiation protocols, while they allow the early steps of neural differentiation to take place, are not able to further sustain this process." @default.
- W2135366903 created "2016-06-24" @default.
- W2135366903 creator A5009504916 @default.
- W2135366903 creator A5010570514 @default.
- W2135366903 creator A5019558417 @default.
- W2135366903 creator A5024798356 @default.
- W2135366903 creator A5039682482 @default.
- W2135366903 creator A5055055447 @default.
- W2135366903 creator A5064533816 @default.
- W2135366903 creator A5067552864 @default.
- W2135366903 creator A5073878691 @default.
- W2135366903 date "2004-11-16" @default.
- W2135366903 modified "2023-10-14" @default.
- W2135366903 title "Molecular pathways involved in neural in vitro differentiation of marrow stromal stem cells" @default.
- W2135366903 cites W1516872401 @default.
- W2135366903 cites W1621124914 @default.
- W2135366903 cites W1678915420 @default.
- W2135366903 cites W1964617786 @default.
- W2135366903 cites W1970865563 @default.
- W2135366903 cites W1976276721 @default.
- W2135366903 cites W1984029045 @default.
- W2135366903 cites W1993640536 @default.
- W2135366903 cites W1997241899 @default.
- W2135366903 cites W2000423768 @default.
- W2135366903 cites W2002320509 @default.
- W2135366903 cites W2002777360 @default.
- W2135366903 cites W2002875788 @default.
- W2135366903 cites W2005848913 @default.
- W2135366903 cites W2012882242 @default.
- W2135366903 cites W2016955301 @default.
- W2135366903 cites W2023189561 @default.
- W2135366903 cites W2030990798 @default.
- W2135366903 cites W2039629780 @default.
- W2135366903 cites W2040475603 @default.
- W2135366903 cites W2041584168 @default.
- W2135366903 cites W2043875758 @default.
- W2135366903 cites W2045182072 @default.
- W2135366903 cites W2052530372 @default.
- W2135366903 cites W2052920071 @default.
- W2135366903 cites W2060184189 @default.
- W2135366903 cites W2064345264 @default.
- W2135366903 cites W2068669272 @default.
- W2135366903 cites W2074760987 @default.
- W2135366903 cites W2080416062 @default.
- W2135366903 cites W2085547973 @default.
- W2135366903 cites W2089521317 @default.
- W2135366903 cites W2090249986 @default.
- W2135366903 cites W2094635970 @default.
- W2135366903 cites W2098663813 @default.
- W2135366903 cites W2106435662 @default.
- W2135366903 cites W2107434982 @default.
- W2135366903 cites W2113887763 @default.
- W2135366903 cites W2125409131 @default.
- W2135366903 cites W2147328185 @default.
- W2135366903 cites W2159999899 @default.
- W2135366903 cites W2163513779 @default.
- W2135366903 cites W2329231956 @default.
- W2135366903 doi "https://doi.org/10.1002/jcb.20315" @default.
- W2135366903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15547939" @default.
- W2135366903 hasPublicationYear "2004" @default.
- W2135366903 type Work @default.
- W2135366903 sameAs 2135366903 @default.
- W2135366903 citedByCount "96" @default.
- W2135366903 countsByYear W21353669032012 @default.
- W2135366903 countsByYear W21353669032013 @default.
- W2135366903 countsByYear W21353669032014 @default.
- W2135366903 countsByYear W21353669032015 @default.
- W2135366903 countsByYear W21353669032016 @default.
- W2135366903 countsByYear W21353669032017 @default.
- W2135366903 countsByYear W21353669032018 @default.
- W2135366903 countsByYear W21353669032019 @default.
- W2135366903 countsByYear W21353669032020 @default.
- W2135366903 countsByYear W21353669032021 @default.
- W2135366903 countsByYear W21353669032022 @default.
- W2135366903 crossrefType "journal-article" @default.
- W2135366903 hasAuthorship W2135366903A5009504916 @default.
- W2135366903 hasAuthorship W2135366903A5010570514 @default.
- W2135366903 hasAuthorship W2135366903A5019558417 @default.
- W2135366903 hasAuthorship W2135366903A5024798356 @default.
- W2135366903 hasAuthorship W2135366903A5039682482 @default.
- W2135366903 hasAuthorship W2135366903A5055055447 @default.
- W2135366903 hasAuthorship W2135366903A5064533816 @default.
- W2135366903 hasAuthorship W2135366903A5067552864 @default.
- W2135366903 hasAuthorship W2135366903A5073878691 @default.
- W2135366903 hasConcept C104317684 @default.
- W2135366903 hasConcept C126619667 @default.
- W2135366903 hasConcept C136834591 @default.
- W2135366903 hasConcept C148738053 @default.
- W2135366903 hasConcept C16930146 @default.
- W2135366903 hasConcept C198826908 @default.
- W2135366903 hasConcept C202751555 @default.
- W2135366903 hasConcept C203014093 @default.
- W2135366903 hasConcept C2776179587 @default.
- W2135366903 hasConcept C2780007613 @default.
- W2135366903 hasConcept C28328180 @default.
- W2135366903 hasConcept C502942594 @default.
- W2135366903 hasConcept C54355233 @default.
- W2135366903 hasConcept C62478195 @default.