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- W2135366961 abstract "Vitamin A turnover was studied in rats fed vitamin A-sufficient (+A) or vitamin A-deficient (-A) diets for 24–25 days. Hepatic vitamin A stores of the +A group (543 µg) were significantly larger than those of the -A group (11 µg) and similarly, the plasma vitamin A concentration of the +A group (56 µg/dl) was significantly higher than that of the -A group (26 µg/dl). Rats were injected intravenously with plasma containing tritium-labeled retinol (3H-ROH) obtained from vitamin A-deficient donor rats previously fed 3H-ROH. Plasma samples from injected recipients were collected over a 48-hour period. Kinetic analysis of plasma tracer concentration versus time curves indicated that the data fit a three-pool model. The plasma vitamin A turnover rate of the +A group was significantly more rapid than that of the -A group (5.19 versus 1.98 µg/hour). Plasma fractional turnover rates for the +A group (1.31 hour-1) were not significantly different from those of the -A group (0.90 hour-1). The data suggest that for both dietary groups, the metabolism of retinol associated with the prealbumin and retinol-binding protein complex involved extensive recycling among the liver, plasma, interstitial fluid and peripheral tissues. vitamin A deficiency vitamin A turnover" @default.
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- W2135366961 date "1981-07-01" @default.
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- W2135366961 title "Vitamin A Turnover in Rats as Influenced by Vitamin A Status" @default.
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- W2135366961 doi "https://doi.org/10.1093/jn/111.7.1135" @default.
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