Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135367483> ?p ?o ?g. }
- W2135367483 endingPage "279" @default.
- W2135367483 startingPage "269" @default.
- W2135367483 abstract "Objective Limited data regarding adrenal involvement in multiple endocrine neoplasia type 1 (MEN1) is available. We describe the characteristics of MEN1-associated adrenal lesions in a large cohort to provide a rationale for their management. Methods Analysis of records from 715 MEN1 patients from a multicentre database between 1956 and 2008. Adrenal lesions were compared with those from a multicentre cohort of 144 patients with adrenal sporadic incidentalomas. Results Adrenal enlargement was reported in 20.4% (146/715) of patients. Adrenal tumours (>10 mm in size) accounted for 58.1% of these cases (10.1% of the whole patient cohort). Tumours were bilateral and >40 mm in size in 12.5 and 19.4% of cases respectively. Hormonal hypersecretion was restricted to patients with tumours and occurred in 15.3% of them. Compared with incidentalomas, MEN1-related tumours exhibited more cases of primary hyperaldosteronism, fewer pheochromocytomas and more adrenocortical carcinomas (ACCs; 13.8 vs 1.3%). Ten ACCs occurred in eight patients. Interestingly, ACCs occurred after several years of follow-up of small adrenal tumours in two of the eight affected patients. Nine of the ten ACCs were classified as stage I or II according to the European Network for the Study of Adrenal Tumors. No evident genotype/phenotype correlation was found for the occurrence of adrenal lesions, endocrine hypersecretion or ACC. Conclusions Adrenal pathology in MEN1 differs from that observed in sporadic incidentalomas. In the absence of relevant symptoms, endocrine biology can be restricted to patients with adrenal tumours and should focus on steroid secretion including the aldosterone–renin system. MEN1 is a high-risk condition for the occurrence of ACCs. It should be considered regardless of the size of the tumour." @default.
- W2135367483 created "2016-06-24" @default.
- W2135367483 creator A5000755434 @default.
- W2135367483 creator A5010322165 @default.
- W2135367483 creator A5015987727 @default.
- W2135367483 creator A5017601520 @default.
- W2135367483 creator A5024635678 @default.
- W2135367483 creator A5047223611 @default.
- W2135367483 creator A5047878606 @default.
- W2135367483 creator A5055028996 @default.
- W2135367483 creator A5064545881 @default.
- W2135367483 creator A5067116958 @default.
- W2135367483 creator A5068070224 @default.
- W2135367483 creator A5069327258 @default.
- W2135367483 creator A5075512837 @default.
- W2135367483 creator A5082549422 @default.
- W2135367483 creator A5082610705 @default.
- W2135367483 creator A5082769105 @default.
- W2135367483 creator A5084162832 @default.
- W2135367483 creator A5089422662 @default.
- W2135367483 date "2012-02-01" @default.
- W2135367483 modified "2023-10-15" @default.
- W2135367483 title "Adrenal involvement in MEN1. Analysis of 715 cases from the Groupe d'étude des Tumeurs Endocrines database" @default.
- W2135367483 cites W122460778 @default.
- W2135367483 cites W1802520718 @default.
- W2135367483 cites W1972860148 @default.
- W2135367483 cites W1976870937 @default.
- W2135367483 cites W1989146112 @default.
- W2135367483 cites W2023370041 @default.
- W2135367483 cites W2026148841 @default.
- W2135367483 cites W2032916856 @default.
- W2135367483 cites W2037200602 @default.
- W2135367483 cites W2042658937 @default.
- W2135367483 cites W2047563579 @default.
- W2135367483 cites W2050413914 @default.
- W2135367483 cites W2051484056 @default.
- W2135367483 cites W2057168818 @default.
- W2135367483 cites W2068845486 @default.
- W2135367483 cites W2073332144 @default.
- W2135367483 cites W2074878869 @default.
- W2135367483 cites W2091231785 @default.
- W2135367483 cites W2099915083 @default.
- W2135367483 cites W2100481514 @default.
- W2135367483 cites W2100500987 @default.
- W2135367483 cites W2104534465 @default.
- W2135367483 cites W2111301538 @default.
- W2135367483 cites W2117792166 @default.
- W2135367483 cites W2118314343 @default.
- W2135367483 cites W2124680091 @default.
- W2135367483 cites W2133664745 @default.
- W2135367483 cites W2138275103 @default.
- W2135367483 cites W2140991656 @default.
- W2135367483 cites W2145168501 @default.
- W2135367483 cites W2151728028 @default.
- W2135367483 cites W2152857438 @default.
- W2135367483 cites W2155188359 @default.
- W2135367483 cites W2157212789 @default.
- W2135367483 cites W2160689593 @default.
- W2135367483 cites W2169457322 @default.
- W2135367483 cites W2173657759 @default.
- W2135367483 cites W4237956739 @default.
- W2135367483 cites W4239536816 @default.
- W2135367483 cites W4244901824 @default.
- W2135367483 cites W4249544063 @default.
- W2135367483 doi "https://doi.org/10.1530/eje-11-0679" @default.
- W2135367483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22084155" @default.
- W2135367483 hasPublicationYear "2012" @default.
- W2135367483 type Work @default.
- W2135367483 sameAs 2135367483 @default.
- W2135367483 citedByCount "155" @default.
- W2135367483 countsByYear W21353674832012 @default.
- W2135367483 countsByYear W21353674832013 @default.
- W2135367483 countsByYear W21353674832014 @default.
- W2135367483 countsByYear W21353674832015 @default.
- W2135367483 countsByYear W21353674832016 @default.
- W2135367483 countsByYear W21353674832017 @default.
- W2135367483 countsByYear W21353674832018 @default.
- W2135367483 countsByYear W21353674832019 @default.
- W2135367483 countsByYear W21353674832020 @default.
- W2135367483 countsByYear W21353674832021 @default.
- W2135367483 countsByYear W21353674832022 @default.
- W2135367483 countsByYear W21353674832023 @default.
- W2135367483 crossrefType "journal-article" @default.
- W2135367483 hasAuthorship W2135367483A5000755434 @default.
- W2135367483 hasAuthorship W2135367483A5010322165 @default.
- W2135367483 hasAuthorship W2135367483A5015987727 @default.
- W2135367483 hasAuthorship W2135367483A5017601520 @default.
- W2135367483 hasAuthorship W2135367483A5024635678 @default.
- W2135367483 hasAuthorship W2135367483A5047223611 @default.
- W2135367483 hasAuthorship W2135367483A5047878606 @default.
- W2135367483 hasAuthorship W2135367483A5055028996 @default.
- W2135367483 hasAuthorship W2135367483A5064545881 @default.
- W2135367483 hasAuthorship W2135367483A5067116958 @default.
- W2135367483 hasAuthorship W2135367483A5068070224 @default.
- W2135367483 hasAuthorship W2135367483A5069327258 @default.
- W2135367483 hasAuthorship W2135367483A5075512837 @default.
- W2135367483 hasAuthorship W2135367483A5082549422 @default.
- W2135367483 hasAuthorship W2135367483A5082610705 @default.