FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135374015> ?p ?o ?g. }

• W2135374015 endingPage "247" @default.
• W2135374015 startingPage "237" @default.
• W2135374015 abstract "All natural tetrapyrroles, including hemes, chlorophylls and vitamin B12, share porphobilinogen (PBG) as a common precursor. Porphobilinogen synthase (PBGS) synthesizes PBG through the asymmetric condensation of two molecules of aminolevulinic acid (ALA). Crystal structures of PBGS from various sources confirm the presence of two distinct binding sites for each ALA molecule, termed A and P. We have solved the structure of the active-site variant D139N of the Mg2+-dependent PBGS from Pseudomonas aeruginosa in complex with the inhibitor 5-fluorolevulinic acid at high resolution. Uniquely, full occupancy of both substrate binding sites each by a single substrate-like molecule was observed. Both inhibitor molecules are covalently bound to two conserved, active-site lysine residues, Lys205 and Lys260, through Schiff bases. The active site now also contains a monovalent cation that may critically enhance enzymatic activity. Based on these structural data, we postulate a catalytic mechanism for P. aeruginosa PBGS initiated by a C-C bond formation between A and P-side ALA, followed by the formation of the intersubstrate Schiff base yielding the product PBG." @default.
• W2135374015 created "2016-06-24" @default.
• W2135374015 creator A5035350917 @default.
• W2135374015 creator A5041916369 @default.
• W2135374015 creator A5060621137 @default.
• W2135374015 creator A5063692146 @default.
• W2135374015 creator A5067307474 @default.
• W2135374015 creator A5071893802 @default.
• W2135374015 creator A5091562604 @default.
• W2135374015 date "2002-07-01" @default.
• W2135374015 modified "2023-10-16" @default.
• W2135374015 title "Structure of Porphobilinogen Synthase from Pseudomonas aeruginosa in Complex with 5-Fluorolevulinic Acid Suggests a Double Schiff Base Mechanism" @default.
• W2135374015 cites W1486417225 @default.
• W2135374015 cites W1505216348 @default.
• W2135374015 cites W1520730837 @default.
• W2135374015 cites W1524100537 @default.
• W2135374015 cites W1985247982 @default.
• W2135374015 cites W1986191025 @default.
• W2135374015 cites W1991748250 @default.
• W2135374015 cites W1994827016 @default.
• W2135374015 cites W1995017064 @default.
• W2135374015 cites W1996607909 @default.
• W2135374015 cites W1998608935 @default.
• W2135374015 cites W2013083986 @default.
• W2135374015 cites W2022330852 @default.
• W2135374015 cites W2028231353 @default.
• W2135374015 cites W2038840577 @default.
• W2135374015 cites W2048139771 @default.
• W2135374015 cites W2054627528 @default.
• W2135374015 cites W2056567154 @default.
• W2135374015 cites W2078248419 @default.
• W2135374015 cites W2086863310 @default.
• W2135374015 cites W2088933990 @default.
• W2135374015 cites W2093420421 @default.
• W2135374015 cites W2118548721 @default.
• W2135374015 cites W2129738109 @default.
• W2135374015 cites W2162756720 @default.
• W2135374015 cites W2163773277 @default.
• W2135374015 cites W2222559137 @default.
• W2135374015 cites W2230504093 @default.
• W2135374015 cites W2238669733 @default.
• W2135374015 doi "https://doi.org/10.1016/s0022-2836(02)00472-2" @default.
• W2135374015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12079382" @default.
• W2135374015 hasPublicationYear "2002" @default.
• W2135374015 type Work @default.
• W2135374015 sameAs 2135374015 @default.
• W2135374015 citedByCount "53" @default.
• W2135374015 countsByYear W21353740152012 @default.
• W2135374015 countsByYear W21353740152015 @default.
• W2135374015 countsByYear W21353740152016 @default.
• W2135374015 countsByYear W21353740152018 @default.
• W2135374015 countsByYear W21353740152019 @default.
• W2135374015 countsByYear W21353740152020 @default.
• W2135374015 countsByYear W21353740152021 @default.
• W2135374015 countsByYear W21353740152023 @default.
• W2135374015 crossrefType "journal-article" @default.
• W2135374015 hasAuthorship W2135374015A5035350917 @default.
• W2135374015 hasAuthorship W2135374015A5041916369 @default.
• W2135374015 hasAuthorship W2135374015A5060621137 @default.
• W2135374015 hasAuthorship W2135374015A5063692146 @default.
• W2135374015 hasAuthorship W2135374015A5067307474 @default.
• W2135374015 hasAuthorship W2135374015A5071893802 @default.
• W2135374015 hasAuthorship W2135374015A5091562604 @default.
• W2135374015 hasConcept C107824862 @default.
• W2135374015 hasConcept C178790620 @default.
• W2135374015 hasConcept C181199279 @default.
• W2135374015 hasConcept C185592680 @default.
• W2135374015 hasConcept C2776428424 @default.
• W2135374015 hasConcept C2776682811 @default.
• W2135374015 hasConcept C2777269803 @default.
• W2135374015 hasConcept C2781374117 @default.
• W2135374015 hasConcept C32909587 @default.
• W2135374015 hasConcept C41183919 @default.
• W2135374015 hasConcept C44538786 @default.
• W2135374015 hasConcept C55493867 @default.
• W2135374015 hasConcept C71240020 @default.
• W2135374015 hasConceptScore W2135374015C107824862 @default.
• W2135374015 hasConceptScore W2135374015C178790620 @default.
• W2135374015 hasConceptScore W2135374015C181199279 @default.
• W2135374015 hasConceptScore W2135374015C185592680 @default.
• W2135374015 hasConceptScore W2135374015C2776428424 @default.
• W2135374015 hasConceptScore W2135374015C2776682811 @default.
• W2135374015 hasConceptScore W2135374015C2777269803 @default.
• W2135374015 hasConceptScore W2135374015C2781374117 @default.
• W2135374015 hasConceptScore W2135374015C32909587 @default.
• W2135374015 hasConceptScore W2135374015C41183919 @default.
• W2135374015 hasConceptScore W2135374015C44538786 @default.
• W2135374015 hasConceptScore W2135374015C55493867 @default.
• W2135374015 hasConceptScore W2135374015C71240020 @default.
• W2135374015 hasIssue "2" @default.
• W2135374015 hasLocation W21353740151 @default.
• W2135374015 hasLocation W21353740152 @default.
• W2135374015 hasOpenAccess W2135374015 @default.
• W2135374015 hasPrimaryLocation W21353740151 @default.
• W2135374015 hasRelatedWork W1553354383 @default.
• W2135374015 hasRelatedWork W1636436468 @default.
• W2135374015 hasRelatedWork W1796692443 @default.
• W2135374015 hasRelatedWork W1981862881 @default.

• next