Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135383313> ?p ?o ?g. }
- W2135383313 endingPage "335" @default.
- W2135383313 startingPage "331" @default.
- W2135383313 abstract "In this study, we investigated the protective effects of S -adenosyl- l -methionine (SAM), which is a precursor of cellular reduced glutathione (GSH), against the hepatotoxicity of pyrrolizidine alkaloid clivorine. MTT assay showed that SAM (5 μM) prevented the cytotoxicity of clivorine on human normal liver L-02 cells. DNA fragmentation assay showed that SAM (5 μM) improved clivorine-induced L-02 cell apoptosis, and the results of Western blot showed that SAM (5 μM) decreased clivorine-induced caspase-3 activation. Cellular GSH analysis showed that when L-02 cells were exposed to different concentrations (0, 3, 10, 30, 50 and 100 μM) of clivorine for 48 h, cellular GSH was decreased in a concentration-dependent manner, while SAM (5 μM) enhanced 50 μM clivorine decreased cellular GSH. Further MTT assay showed that 5 mM GSH and 5 mM N -acetyl- l -cysteine (NAC) both had protective effects against clivorine-induced hepatotoxicity. Our results suggest that SAM has protective effects against the hepatotoxicity of clivorine possibly by enhancing cellular GSH level and increasing cellular defensive ability against clivorine-induced cytotoxicity." @default.
- W2135383313 created "2016-06-24" @default.
- W2135383313 creator A5000891681 @default.
- W2135383313 creator A5011479283 @default.
- W2135383313 creator A5040558103 @default.
- W2135383313 date "2008-11-01" @default.
- W2135383313 modified "2023-10-17" @default.
- W2135383313 title "Protection of S-adenosyl methionine against the toxicity of clivorine on hepatocytes" @default.
- W2135383313 cites W1555978010 @default.
- W2135383313 cites W1568477117 @default.
- W2135383313 cites W1693286927 @default.
- W2135383313 cites W1823703597 @default.
- W2135383313 cites W1895999434 @default.
- W2135383313 cites W1936829634 @default.
- W2135383313 cites W1942214720 @default.
- W2135383313 cites W1966306426 @default.
- W2135383313 cites W1974782561 @default.
- W2135383313 cites W1982009503 @default.
- W2135383313 cites W1991425976 @default.
- W2135383313 cites W1991689100 @default.
- W2135383313 cites W1994318934 @default.
- W2135383313 cites W2001786662 @default.
- W2135383313 cites W2012401238 @default.
- W2135383313 cites W2019141005 @default.
- W2135383313 cites W2033024401 @default.
- W2135383313 cites W2036525238 @default.
- W2135383313 cites W2038635432 @default.
- W2135383313 cites W2045753882 @default.
- W2135383313 cites W2054526986 @default.
- W2135383313 cites W2054534199 @default.
- W2135383313 cites W2064697408 @default.
- W2135383313 cites W2067934373 @default.
- W2135383313 cites W2087656474 @default.
- W2135383313 cites W2092244018 @default.
- W2135383313 cites W2100357482 @default.
- W2135383313 cites W2104359514 @default.
- W2135383313 cites W2126791697 @default.
- W2135383313 cites W2149623959 @default.
- W2135383313 cites W2160942082 @default.
- W2135383313 cites W2167611648 @default.
- W2135383313 cites W2171355310 @default.
- W2135383313 cites W2951973000 @default.
- W2135383313 cites W2953303682 @default.
- W2135383313 cites W399741643 @default.
- W2135383313 cites W72567716 @default.
- W2135383313 cites W934238917 @default.
- W2135383313 doi "https://doi.org/10.1016/j.etap.2008.06.007" @default.
- W2135383313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21791384" @default.
- W2135383313 hasPublicationYear "2008" @default.
- W2135383313 type Work @default.
- W2135383313 sameAs 2135383313 @default.
- W2135383313 citedByCount "6" @default.
- W2135383313 countsByYear W21353833132012 @default.
- W2135383313 countsByYear W21353833132014 @default.
- W2135383313 countsByYear W21353833132016 @default.
- W2135383313 crossrefType "journal-article" @default.
- W2135383313 hasAuthorship W2135383313A5000891681 @default.
- W2135383313 hasAuthorship W2135383313A5011479283 @default.
- W2135383313 hasAuthorship W2135383313A5040558103 @default.
- W2135383313 hasConcept C109316439 @default.
- W2135383313 hasConcept C153911025 @default.
- W2135383313 hasConcept C178790620 @default.
- W2135383313 hasConcept C181199279 @default.
- W2135383313 hasConcept C185592680 @default.
- W2135383313 hasConcept C18903297 @default.
- W2135383313 hasConcept C190283241 @default.
- W2135383313 hasConcept C191015642 @default.
- W2135383313 hasConcept C202751555 @default.
- W2135383313 hasConcept C2779201268 @default.
- W2135383313 hasConcept C2780783641 @default.
- W2135383313 hasConcept C2780912031 @default.
- W2135383313 hasConcept C29730261 @default.
- W2135383313 hasConcept C31573885 @default.
- W2135383313 hasConcept C43759708 @default.
- W2135383313 hasConcept C515207424 @default.
- W2135383313 hasConcept C538909803 @default.
- W2135383313 hasConcept C55493867 @default.
- W2135383313 hasConcept C86803240 @default.
- W2135383313 hasConcept C98274493 @default.
- W2135383313 hasConceptScore W2135383313C109316439 @default.
- W2135383313 hasConceptScore W2135383313C153911025 @default.
- W2135383313 hasConceptScore W2135383313C178790620 @default.
- W2135383313 hasConceptScore W2135383313C181199279 @default.
- W2135383313 hasConceptScore W2135383313C185592680 @default.
- W2135383313 hasConceptScore W2135383313C18903297 @default.
- W2135383313 hasConceptScore W2135383313C190283241 @default.
- W2135383313 hasConceptScore W2135383313C191015642 @default.
- W2135383313 hasConceptScore W2135383313C202751555 @default.
- W2135383313 hasConceptScore W2135383313C2779201268 @default.
- W2135383313 hasConceptScore W2135383313C2780783641 @default.
- W2135383313 hasConceptScore W2135383313C2780912031 @default.
- W2135383313 hasConceptScore W2135383313C29730261 @default.
- W2135383313 hasConceptScore W2135383313C31573885 @default.
- W2135383313 hasConceptScore W2135383313C43759708 @default.
- W2135383313 hasConceptScore W2135383313C515207424 @default.
- W2135383313 hasConceptScore W2135383313C538909803 @default.
- W2135383313 hasConceptScore W2135383313C55493867 @default.
- W2135383313 hasConceptScore W2135383313C86803240 @default.