FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135389367> ?p ?o ?g. }

• W2135389367 endingPage "178" @default.
• W2135389367 startingPage "170" @default.
• W2135389367 abstract "Bacterial cytidine-phosphate-guanosine (CpG-DNA) activates antigen-presenting cells (APC) and drives T helper 1 (Th1)-polarized immune responses in the mouse. Claims have been made that CpG-DNA costimulates murine T cells. We examined the direct and indirect effects of CpG-oligodeoxynucleotides (CpG-ODN) on human T-cell activation. CpG-ODN failed to costimulate purified human T cells activated with alpha-CD3 or alpha-T-cell receptor (TCR)alphabeta antibodies. In contrast, CpG-ODN sequence-specifically caused increased expression of CD69 on CD4 and CD8 T cells when peripheral blood mononuclear cells (PBMC) were stimulated via alpha-CD3. CpG-ODN and alpha-CD3 stimulation synergized to induce interferon-gamma (IFN-gamma) in T cells and natural killer (NK) cells, as shown by intracellular fluorescence-activated cell sorter (FACS) staining. These effects of CpG-ODN on human T cells were caused by the release of IFN type I (IFN-I) and interleukin-12 (IL-12) from PBMC. Enhancement of CD69 expression on alpha-CD3-triggered T cells could be reproduced in a coculture transwell system of purified T cells and PBMC, was inhibited by neutralizing antibodies to IFN-I and could be mimicked by adding exogenous IFN-I. Furthermore, neutralization of either IFN-I or IL-12 diminished, and in combination abolished, IFN-gamma production. These findings show that CpG-ODN potentiate TCR-triggered activation of human T cells in an APC-dependent manner." @default.
• W2135389367 created "2016-06-24" @default.
• W2135389367 creator A5004324970 @default.
• W2135389367 creator A5014333058 @default.
• W2135389367 creator A5042096114 @default.
• W2135389367 creator A5046981639 @default.
• W2135389367 creator A5068349575 @default.
• W2135389367 creator A5069550552 @default.
• W2135389367 date "2000-02-01" @default.
• W2135389367 modified "2023-10-15" @default.
• W2135389367 title "CpG-oligodeoxynucleotides enhance T-cell receptor-triggered interferon-γ production and up-regulation of CD69 via induction of antigen-presenting cell-derived interferon type I and interleukin-12" @default.
• W2135389367 cites W1604795805 @default.
• W2135389367 cites W1636901091 @default.
• W2135389367 cites W1660215706 @default.
• W2135389367 cites W1930059740 @default.
• W2135389367 cites W1966279732 @default.
• W2135389367 cites W1990374418 @default.
• W2135389367 cites W2004726009 @default.
• W2135389367 cites W2009660986 @default.
• W2135389367 cites W2010222913 @default.
• W2135389367 cites W2021841002 @default.
• W2135389367 cites W2025345914 @default.
• W2135389367 cites W2030689421 @default.
• W2135389367 cites W2037233457 @default.
• W2135389367 cites W2047366876 @default.
• W2135389367 cites W2054298647 @default.
• W2135389367 cites W2074778496 @default.
• W2135389367 cites W2076124962 @default.
• W2135389367 cites W2091670195 @default.
• W2135389367 cites W2092128665 @default.
• W2135389367 cites W2112295570 @default.
• W2135389367 cites W2116723397 @default.
• W2135389367 cites W2117761826 @default.
• W2135389367 cites W2131642660 @default.
• W2135389367 cites W2145464179 @default.
• W2135389367 cites W2155991561 @default.
• W2135389367 cites W2165645608 @default.
• W2135389367 cites W2429246466 @default.
• W2135389367 cites W4313333815 @default.
• W2135389367 cites W4313342408 @default.
• W2135389367 cites W4313342413 @default.
• W2135389367 doi "https://doi.org/10.1046/j.1365-2567.2000.00964.x" @default.
• W2135389367 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2327140" @default.
• W2135389367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10692033" @default.
• W2135389367 hasPublicationYear "2000" @default.
• W2135389367 type Work @default.
• W2135389367 sameAs 2135389367 @default.
• W2135389367 citedByCount "104" @default.
• W2135389367 countsByYear W21353893672012 @default.
• W2135389367 countsByYear W21353893672013 @default.
• W2135389367 countsByYear W21353893672014 @default.
• W2135389367 countsByYear W21353893672015 @default.
• W2135389367 countsByYear W21353893672016 @default.
• W2135389367 countsByYear W21353893672017 @default.
• W2135389367 countsByYear W21353893672018 @default.
• W2135389367 countsByYear W21353893672019 @default.
• W2135389367 countsByYear W21353893672020 @default.
• W2135389367 countsByYear W21353893672021 @default.
• W2135389367 countsByYear W21353893672022 @default.
• W2135389367 countsByYear W21353893672023 @default.
• W2135389367 crossrefType "journal-article" @default.
• W2135389367 hasAuthorship W2135389367A5004324970 @default.
• W2135389367 hasAuthorship W2135389367A5014333058 @default.
• W2135389367 hasAuthorship W2135389367A5042096114 @default.
• W2135389367 hasAuthorship W2135389367A5046981639 @default.
• W2135389367 hasAuthorship W2135389367A5068349575 @default.
• W2135389367 hasAuthorship W2135389367A5069550552 @default.
• W2135389367 hasBestOaLocation W21353893671 @default.
• W2135389367 hasConcept C104317684 @default.
• W2135389367 hasConcept C114684123 @default.
• W2135389367 hasConcept C129374314 @default.
• W2135389367 hasConcept C147483822 @default.
• W2135389367 hasConcept C149532602 @default.
• W2135389367 hasConcept C150194340 @default.
• W2135389367 hasConcept C153911025 @default.
• W2135389367 hasConcept C154317977 @default.
• W2135389367 hasConcept C167672396 @default.
• W2135389367 hasConcept C190727270 @default.
• W2135389367 hasConcept C19317047 @default.
• W2135389367 hasConcept C202751555 @default.
• W2135389367 hasConcept C203014093 @default.
• W2135389367 hasConcept C22801619 @default.
• W2135389367 hasConcept C2776090121 @default.
• W2135389367 hasConcept C2777371288 @default.
• W2135389367 hasConcept C55493867 @default.
• W2135389367 hasConcept C79484868 @default.
• W2135389367 hasConcept C86803240 @default.
• W2135389367 hasConcept C8891405 @default.
• W2135389367 hasConceptScore W2135389367C104317684 @default.
• W2135389367 hasConceptScore W2135389367C114684123 @default.
• W2135389367 hasConceptScore W2135389367C129374314 @default.
• W2135389367 hasConceptScore W2135389367C147483822 @default.
• W2135389367 hasConceptScore W2135389367C149532602 @default.
• W2135389367 hasConceptScore W2135389367C150194340 @default.
• W2135389367 hasConceptScore W2135389367C153911025 @default.
• W2135389367 hasConceptScore W2135389367C154317977 @default.
• W2135389367 hasConceptScore W2135389367C167672396 @default.
• W2135389367 hasConceptScore W2135389367C190727270 @default.

• next