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• W2135391751 startingPage "383" @default.
• W2135391751 abstract "Pruritus is a common and distressing symptom in patients with chronic kidney disease. The most recent epidemiologic data have suggested that approximately 40% of patients with end-stage renal disease experience moderate to severe pruritus and that uremic pruritus (UP) has a major clinical impact, being associated strongly with poor quality of life, impaired sleep, depression, and increased mortality. The pathogenesis of UP remains largely unclear, although several theories on etiologic or contributing factors have been proposed including increased systemic inflammation; abnormal serum parathyroid hormone, calcium, and phosphorus levels; an imbalance in opiate receptors; and a neuropathic process. UP can present somewhat variably, although it tends to affect large, discontinuous, but symmetric, areas of skin and to be most symptomatic at night. A variety of alternative systemic or dermatologic conditions should be considered, especially in patients with asymmetric pruritus or other atypical features. Treatment initially should focus on aggressive skin hydration, patient education on minimizing scratching, and optimization of the aspects of chronic kidney disease care that are most relevant to pruritus, including dialysis adequacy and serum parathyroid hormone, calcium, and phosphorus management. Data for therapy specifically for UP remain limited, although topical therapies, gabapentin, type B ultraviolet light phototherapy, acupuncture, and opioid-receptor modulators all may play a role." @default.
• W2135391751 created "2016-06-24" @default.
• W2135391751 creator A5009922159 @default.
• W2135391751 creator A5056200579 @default.
• W2135391751 creator A5087995141 @default.
• W2135391751 date "2015-07-01" @default.
• W2135391751 modified "2023-10-06" @default.
• W2135391751 title "Pruritus in Kidney Disease" @default.
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• W2135391751 doi "https://doi.org/10.1016/j.semnephrol.2015.06.009" @default.
• W2135391751 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5497472" @default.
• W2135391751 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26355256" @default.
• W2135391751 hasPublicationYear "2015" @default.
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