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- W2135392922 endingPage "1330008" @default.
- W2135392922 startingPage "1330008" @default.
- W2135392922 abstract "The large use of nonlinear laser scanning microscopy in the past decade paved the way for potential clinical application of this imaging technique. Modern nonlinear microscopy techniques offer promising label-free solutions to improve diagnostic performances on tissues. In particular, the combination of multiple nonlinear imaging techniques in the same microscope allows integrating morphological with functional information in a morpho-functional scheme. Such approach provides a high-resolution label-free alternative to both histological and immunohistochemical examination of tissues and is becoming increasingly popular among the clinical community. Nevertheless, several technical improvements, including automatic scanning and image analysis, are required before the technique represents a standard diagnostic method. In this review paper, we highlight the capabilities of multimodal nonlinear microscopy for tissue imaging, by providing various examples on colon, arterial and skin tissues. The comparison between images acquired using multimodal nonlinear microscopy and histology shows a good agreement between the two methods. The results demonstrate that multimodal nonlinear microscopy is a powerful label-free alternative to standard histopathological methods and has the potential to find a stable place in the clinical setting in the near future." @default.
- W2135392922 created "2016-06-24" @default.
- W2135392922 creator A5027289061 @default.
- W2135392922 creator A5054913174 @default.
- W2135392922 date "2014-09-01" @default.
- W2135392922 modified "2023-09-26" @default.
- W2135392922 title "Multimodal nonlinear microscopy: A powerful label-free method for supporting standard diagnostics on biological tissues" @default.
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