FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135436036> ?p ?o ?g. }

• W2135436036 endingPage "269" @default.
• W2135436036 startingPage "264" @default.
• W2135436036 abstract "Neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), familial adenomatous polyposis (FAP), von Hippel-Lindau syndrome (VHL), and Gorlin syndrome (GS) are single gene diseases that predispose to early onset tumours. Few studies have assessed the effect of these diseases on life expectancy. This study's aim was to assess this effect, and to test the hypothesis that genetic registers increase survival.NF1, NF2, VHL, FAP, and GS patients were identified through the North West Regional Genetic Register Service and the North West Cancer Intelligence Service. Information on benign and malignant tumours, and deaths were obtained. Kaplan-Meier curves were used to show actuarial survival rates for each disease, compared to the local population, and in patients diagnosed pre/post the regional genetic register. Log rank (Mantel-Cox) tests were used to compare survival between groups.Life expectancies were significantly reduced for all diseases investigated compared with the local population (80.0 years) (p=0.05). GS had the longest life expectancy at 73.4 years, followed by NF1 at 71.5 years, NF2 at 69.0 years, FAP at 63.6 years, and VHL at 52.5 years. Patients diagnosed after establishment of the genetic register had an increase in survival compared to those diagnosed pre-1990: NF2 (14.7 years), FAP (13.9 years), VHL (16.3 years), and GS (11.2 years).Life expectancy for all five diseases was less than normal, although in recent years this reached the level of the local population in GS. Although there have been improvements in all conditions which may in part be attributable to better targeted care through the genetic register service, more needs to be done to address the very poor life expectancy in VHL." @default.
• W2135436036 created "2016-06-24" @default.
• W2135436036 creator A5016387286 @default.
• W2135436036 creator A5020519888 @default.
• W2135436036 creator A5065103918 @default.
• W2135436036 creator A5074781709 @default.
• W2135436036 creator A5083774483 @default.
• W2135436036 creator A5084156587 @default.
• W2135436036 creator A5087003938 @default.
• W2135436036 date "2012-02-23" @default.
• W2135436036 modified "2023-09-26" @default.
• W2135436036 title "Life expectancy in hereditary cancer predisposing diseases: an observational study" @default.
• W2135436036 cites W128563030 @default.
• W2135436036 cites W1974290681 @default.
• W2135436036 cites W1980003605 @default.
• W2135436036 cites W1989423286 @default.
• W2135436036 cites W1990143243 @default.
• W2135436036 cites W1993948858 @default.
• W2135436036 cites W2020898706 @default.
• W2135436036 cites W2022510743 @default.
• W2135436036 cites W2024955968 @default.
• W2135436036 cites W2026686051 @default.
• W2135436036 cites W2027577206 @default.
• W2135436036 cites W2034029713 @default.
• W2135436036 cites W2052186241 @default.
• W2135436036 cites W2058431246 @default.
• W2135436036 cites W2059852545 @default.
• W2135436036 cites W2085792148 @default.
• W2135436036 cites W2088098973 @default.
• W2135436036 cites W2090789862 @default.
• W2135436036 cites W2093956200 @default.
• W2135436036 cites W2103173315 @default.
• W2135436036 cites W2104740090 @default.
• W2135436036 cites W2112064177 @default.
• W2135436036 cites W2137036286 @default.
• W2135436036 cites W2137167848 @default.
• W2135436036 cites W2143571956 @default.
• W2135436036 cites W2143590679 @default.
• W2135436036 cites W2146322961 @default.
• W2135436036 cites W2157450466 @default.
• W2135436036 cites W2161793046 @default.
• W2135436036 cites W2162981140 @default.
• W2135436036 cites W2167037597 @default.
• W2135436036 cites W2168778512 @default.
• W2135436036 cites W2169850703 @default.
• W2135436036 cites W2170249858 @default.
• W2135436036 cites W2171756643 @default.
• W2135436036 cites W2286377525 @default.
• W2135436036 cites W2330798445 @default.
• W2135436036 cites W284074768 @default.
• W2135436036 cites W3036997304 @default.
• W2135436036 cites W81322481 @default.
• W2135436036 doi "https://doi.org/10.1136/jmedgenet-2011-100562" @default.
• W2135436036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22362873" @default.
• W2135436036 hasPublicationYear "2012" @default.
• W2135436036 type Work @default.
• W2135436036 sameAs 2135436036 @default.
• W2135436036 citedByCount "116" @default.
• W2135436036 countsByYear W21354360362012 @default.
• W2135436036 countsByYear W21354360362013 @default.
• W2135436036 countsByYear W21354360362014 @default.
• W2135436036 countsByYear W21354360362015 @default.
• W2135436036 countsByYear W21354360362016 @default.
• W2135436036 countsByYear W21354360362017 @default.
• W2135436036 countsByYear W21354360362018 @default.
• W2135436036 countsByYear W21354360362019 @default.
• W2135436036 countsByYear W21354360362020 @default.
• W2135436036 countsByYear W21354360362021 @default.
• W2135436036 countsByYear W21354360362022 @default.
• W2135436036 countsByYear W21354360362023 @default.
• W2135436036 crossrefType "journal-article" @default.
• W2135436036 hasAuthorship W2135436036A5016387286 @default.
• W2135436036 hasAuthorship W2135436036A5020519888 @default.
• W2135436036 hasAuthorship W2135436036A5065103918 @default.
• W2135436036 hasAuthorship W2135436036A5074781709 @default.
• W2135436036 hasAuthorship W2135436036A5083774483 @default.
• W2135436036 hasAuthorship W2135436036A5084156587 @default.
• W2135436036 hasAuthorship W2135436036A5087003938 @default.
• W2135436036 hasConcept C121608353 @default.
• W2135436036 hasConcept C126322002 @default.
• W2135436036 hasConcept C133925201 @default.
• W2135436036 hasConcept C142724271 @default.
• W2135436036 hasConcept C187212893 @default.
• W2135436036 hasConcept C2778527826 @default.
• W2135436036 hasConcept C2778984943 @default.
• W2135436036 hasConcept C2779134260 @default.
• W2135436036 hasConcept C2780558122 @default.
• W2135436036 hasConcept C2780814781 @default.
• W2135436036 hasConcept C2908647359 @default.
• W2135436036 hasConcept C526805850 @default.
• W2135436036 hasConcept C71924100 @default.
• W2135436036 hasConcept C99454951 @default.
• W2135436036 hasConceptScore W2135436036C121608353 @default.
• W2135436036 hasConceptScore W2135436036C126322002 @default.
• W2135436036 hasConceptScore W2135436036C133925201 @default.
• W2135436036 hasConceptScore W2135436036C142724271 @default.
• W2135436036 hasConceptScore W2135436036C187212893 @default.
• W2135436036 hasConceptScore W2135436036C2778527826 @default.

• next