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- W2135439945 abstract "No AccessJournal of UrologyAdult Urology1 Oct 2009Optimizing Prostate Cancer Detection: 8 Versus 12-Core Biopsy Protocol Jean J.M.C.H. de la Rosette, Margot H. Wink, Charalampos Mamoulakis, Niels Wondergem, Fiebo J.C. ten Kate, Koos Zwinderman, Theo M. de Reijke, and Hessel Wijkstra Jean J.M.C.H. de la RosetteJean J.M.C.H. de la Rosette Department of Urology, Academic Medical Center, University Hospital, Amsterdam, The Netherlands Financial interest and/or other relationship with Galil Medical, BSC and American Medical Systems. More articles by this author , Margot H. WinkMargot H. Wink Department of Urology, Academic Medical Center, University Hospital, Amsterdam, The Netherlands More articles by this author , Charalampos MamoulakisCharalampos Mamoulakis Department of Urology, Academic Medical Center, University Hospital, Amsterdam, The Netherlands More articles by this author , Niels WondergemNiels Wondergem Department of Urology, Academic Medical Center, University Hospital, Amsterdam, The Netherlands More articles by this author , Fiebo J.C. ten KateFiebo J.C. ten Kate Department of Pathology, Academic Medical Center, University Hospital, Amsterdam, The Netherlands More articles by this author , Koos ZwindermanKoos Zwinderman Department of Epidemiology, Academic Medical Center, University Hospital, Amsterdam, The Netherlands More articles by this author , Theo M. de ReijkeTheo M. de Reijke Department of Urology, Academic Medical Center, University Hospital, Amsterdam, The Netherlands More articles by this author , and Hessel WijkstraHessel Wijkstra Department of Urology, Academic Medical Center, University Hospital, Amsterdam, The Netherlands More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2009.06.037AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We compared prostate cancer detection rates achieved using an 8 and 12-core biopsy protocol in a clinical population to determine the significance of additional transition zone sampling on repeat biopsy. Materials and Methods: Between September 2004 and September 2007, 269 eligible patients with a clinical suspicion of prostate cancer referred to our department were randomized to an 8-core lateral (group 1) or a 12-core lateral and parasagittal (group 2) transrectal ultrasound guided prostate biopsy protocol. Study inclusion criteria were age dependent increased serum prostate specific antigen (1.25 ng/ml or greater at ages less than 50 years, 1.75 or greater at ages 50 to less than 60 years, 2.25 or greater at ages 60 to less than 70 years and 3.25 or greater at ages 70 years or greater), positive digital rectal examination and/or suspicious transrectal ultrasound. After negative first round biopsy patients underwent 12-core biopsy, including 4 transition zone cores. Results: Nine patients were excluded from analysis because of protocol violation or they did not complete the whole biopsy procedure due to discomfort. The cancer detection rate in groups 1 and 2 did not differ significantly (34.1% or 45 of 132 patients and 38.3% or 49 of 128, respectively, p = 0.48). Detected cancer median Gleason scores were similar in the groups. Of 109 patients who underwent repeat biopsy prostate cancer was detected in 20 (14.4%), of whom 9 had positive cores from the transition zone and 6 had positive biopsies only from the transition zone. Conclusions: There are no statistically significant differences in the prostate cancer detection rate between 8 and 12-core prostate biopsy protocols. Transition zone biopsies contribute to prostate cancer detection in a repeat biopsy protocol. References 1 : Random systematic versus directed ultrasound guided transrectal core biopsies of the prostate. J Urol1989; 142: 71. Abstract, Google Scholar 2 : C: The sextant protocol for ultrasound-guided core biopsies of the prostate underestimates the presence of cancer. Urology1997; 50: 562. 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Google Scholar © 2009 by American Urological AssociationFiguresReferencesRelatedDetailsCited byIrani J, Blanchet P, Salomon L, Coloby P, Hubert J, Malavaud B and Mottet N (2018) Is an Extended 20-Core Prostate Biopsy Protocol More Efficient than the Standard 12-Core? A Randomized Multicenter TrialJournal of Urology, VOL. 190, NO. 1, (77-83), Online publication date: 1-Jul-2013.Hadaschik B, Kuru T, Tulea C, Rieker P, Popeneciu I, Simpfendörfer T, Huber J, Zogal P, Teber D, Pahernik S, Roethke M, Zamecnik P, Roth W, Sakas G, Schlemmer H and Hohenfellner M (2018) A Novel Stereotactic Prostate Biopsy System Integrating Pre-Interventional Magnetic Resonance Imaging and Live Ultrasound FusionJournal of Urology, VOL. 186, NO. 6, (2214-2220), Online publication date: 1-Dec-2011. Volume 182Issue 4October 2009Page: 1329-1336 Advertisement Copyright & Permissions© 2009 by American Urological AssociationKeywordsprostateprostatic neoplasmsultrasonographybiopsyAcknowledgmentsFiebo J. W. ten Kate assisted with the study.MetricsAuthor Information Jean J.M.C.H. de la Rosette Department of Urology, Academic Medical Center, University Hospital, Amsterdam, The Netherlands Financial interest and/or other relationship with Galil Medical, BSC and American Medical Systems. More articles by this author Margot H. Wink Department of Urology, Academic Medical Center, University Hospital, Amsterdam, The Netherlands More articles by this author Charalampos Mamoulakis Department of Urology, Academic Medical Center, University Hospital, Amsterdam, The Netherlands More articles by this author Niels Wondergem Department of Urology, Academic Medical Center, University Hospital, Amsterdam, The Netherlands More articles by this author Fiebo J.C. ten Kate Department of Pathology, Academic Medical Center, University Hospital, Amsterdam, The Netherlands More articles by this author Koos Zwinderman Department of Epidemiology, Academic Medical Center, University Hospital, Amsterdam, The Netherlands More articles by this author Theo M. de Reijke Department of Urology, Academic Medical Center, University Hospital, Amsterdam, The Netherlands More articles by this author Hessel Wijkstra Department of Urology, Academic Medical Center, University Hospital, Amsterdam, The Netherlands More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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