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• W2135447179 abstract "You have accessJournal of UrologyProstate Cancer: Basic Research1 Apr 2011730 THE ATORVASTATIN TARGET SCD1 IDENTIFIED WITHIN THE GENE EXPRESSION SIGNATURE OF HIGH BMI PROSTATE CANCER PATIENTS Patrick Parker, Shashwat Sharad, Anjali Srivastava, Suma Ravulapalli, Yongmei Chen, Hua Li, Gyorgy Petrovics, and Albert Dobi Patrick ParkerPatrick Parker Washington, DC More articles by this author , Shashwat SharadShashwat Sharad Rockville, MD More articles by this author , Anjali SrivastavaAnjali Srivastava Rockville, MD More articles by this author , Suma RavulapalliSuma Ravulapalli Rockville, MD More articles by this author , Yongmei ChenYongmei Chen Rockville, MD More articles by this author , Hua LiHua Li Rockville, MD More articles by this author , Gyorgy PetrovicsGyorgy Petrovics Rockville, MD More articles by this author , and Albert DobiAlbert Dobi Rockville, MD More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1699AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Obesity is one of the largest medical challenges in the USA. Recent studies highlighted the association of obesity with prostate cancer aggressiveness suggesting that obesity-associated altered metabolic conditions may be linked to prostate cancer progression. However, obesity-associated gene expression alterations need to be better understood in prostate cancer. The objective of this study was to evaluate elevated BMI-associated prostate cancer gene expression signatures. METHODS Prostate cancer cells and matching non-adjacent normal epithelial cells were selected by laser capture microdissection from frozen radical prostatectomy specimens of patients with normal- and high BMI. Gene expression analyses were performed by using HG-U133A Affymetrix microarrays. Both Robust Multi-array Analysis and single-probe analysis approaches were employed for data analysis to assure enrichment of significant gene expression alterations. Tumor-over-normal gene expression ratios were calculated and data were further analyzed by applying a three-fold cutoff. To pinpoint central regulatory nodes of gene expression alterations knowledge-based pathway analysis, gene ontology and comparative meta-analysis of obesity related independent datasets were performed. RESULTS Bioinformatic analyses revealed associations of high BMI with cholesterol and lipid metabolism associated genes within fatty acid synthesis and oxidation-reduction pathways. The identified high BMI-associated genes were tightly connected to genes involved in lipid metabolism, cholesterol homeostasis, and tumorigenesis. The analysis highlighted the association of stearoyl-CoA desaturase (SCD1) with elevated BMI. CONCLUSIONS Our study revealed that SCD1, a known target of atorvastatin, may play a mechanistic role in the recently noted beneficial effects of statin treatment in reducing biochemical recurrence of prostate cancer. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e293 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Patrick Parker Washington, DC More articles by this author Shashwat Sharad Rockville, MD More articles by this author Anjali Srivastava Rockville, MD More articles by this author Suma Ravulapalli Rockville, MD More articles by this author Yongmei Chen Rockville, MD More articles by this author Hua Li Rockville, MD More articles by this author Gyorgy Petrovics Rockville, MD More articles by this author Albert Dobi Rockville, MD More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2135447179 date "2011-04-01" @default.
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• W2135447179 title "730 THE ATORVASTATIN TARGET SCD1 IDENTIFIED WITHIN THE GENE EXPRESSION SIGNATURE OF HIGH BMI PROSTATE CANCER PATIENTS" @default.
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