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- W2135471957 abstract "Small heat shock proteins (sHsps) are ubiquitous molecular chaperones that prevent the unspecific aggregation of proteins. So far, Hsp26 was the only unambiguously identified member of the sHsp family in Saccharomyces cerevisiae. We show here that the sHsp system in the cytosol of S. cerevisiae consists of two proteins, Hsp26 and Hsp42. Hsp42 forms large dynamic oligomers with a barrel-like structure. In contrast to Hsp26, which functions predominantly at heat shock temperatures, Hsp42 is active as a chaperone under all conditions tested in vivo and in vitro. Under heat shock conditions, both Hsp42 and Hsp26 suppress the aggregation of one-third of the cytosolic proteins. This subset is about 90% overlapping for Hsp42 and Hsp26. The sHsp substrates belong to different biochemical pathways. This indicates a general protective function of sHsps for proteome stability in S. cerevisiae. Consistent with this observation, sHsp knockout strains show phenotypical defects. Taken together, our results define Hsp42 as an important player for protein homeostasis at physiological and under stress conditions." @default.
- W2135471957 created "2016-06-24" @default.
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- W2135471957 date "2004-01-29" @default.
- W2135471957 modified "2023-09-27" @default.
- W2135471957 title "Hsp42 is the general small heat shock protein in the cytosol of Saccharomyces cerevisiae" @default.
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- W2135471957 cites W1589193262 @default.
- W2135471957 cites W1589290041 @default.
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- W2135471957 cites W1790977108 @default.
- W2135471957 cites W1797775581 @default.
- W2135471957 cites W1798029925 @default.
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- W2135471957 cites W1974886740 @default.
- W2135471957 cites W1976940452 @default.
- W2135471957 cites W1991292950 @default.
- W2135471957 cites W1992067048 @default.
- W2135471957 cites W1995340350 @default.
- W2135471957 cites W2006910882 @default.
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- W2135471957 doi "https://doi.org/10.1038/sj.emboj.7600080" @default.
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