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• W2135496684 abstract "Penaeidin antimicrobial peptides in penaeid shrimps are an important component of their innate immune system that provides immunity against infection caused by several gram-positive bacteria and filamentous fungal species. Despite the knowledge on the identification and characterization of these peptides in penaeid shrimps, little is known about the evolutionary pattern of these peptides and the underlying genetic mechanisms that maintain high sequence diversities in the penaeidin gene family. Based on the phylogenetic analyses and maximum likelihood-based codon substitution analyses, here we present the convincing evidence that multiple copies of penaeidins have evolved by gene duplication, and positive Darwinian selection (adaptive evolution) is the likely cause of accelerated rate of amino acid substitutions among these duplicated genes. While the average ratio of non-synonymous to synonymous substitutions (ω) for the entire coding region of both active domains is 0.9805, few codon sites showed significantly higher ω (3.73). The likelihood ratio tests that compare models incorporating positive selection (ω > 1) at certain codon sites with models not incorporating positive selection (ω < 1), failed to reject (p = 0) the evidence of positive Darwinian selection. The rapid adaptive evolution of this gene family might be directed by the pathogens and the faster rate of amino acid substitutions in the N-terminal proline-rich and C-terminal cysteine-rich domains could be due to their direct involvement in the protection against pathogens. When the host expose to different habitats/environment an accelerated rate of amino acid substitutions in both the active domains may also be expected." @default.
• W2135496684 created "2016-06-24" @default.
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• W2135496684 date "2007-09-01" @default.
• W2135496684 modified "2023-10-17" @default.
• W2135496684 title "Adaptive evolution after duplication of penaeidin antimicrobial peptides" @default.
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• W2135496684 doi "https://doi.org/10.1016/j.fsi.2007.01.003" @default.
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