FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135508788> ?p ?o ?g. }

• W2135508788 endingPage "11622" @default.
• W2135508788 startingPage "11613" @default.
• W2135508788 abstract "Abstract HMGA1 proteins are architectural transcription factors that are overexpressed in a range of human malignancies, including pancreatic adenocarcinoma. We hypothesized that HMGA1 expression is a determinant of cellular invasiveness and metastasis in pancreatic cancer. Stable silencing of HMGA1 in MiaPaCa2 and PANC1 pancreatic adenocarcinoma cells was achieved by transfection of short hairpin RNA–generating vectors. Additionally, stable overexpression of HMGA1 in MiaPaCa2 cells (characterized by low levels of inherent HMGA1 expression) was achieved. HMGA1 silencing resulted in significant reductions in cellular invasiveness through Matrigel; in cellular matrix metalloproteinase-9 (MMP-9) activity, mRNA levels, and gene promoter activity; and in Akt phosphorylation at Ser473. Conversely, forced HMGA1 overexpression resulted in significant increases in cellular invasiveness; in cellular MMP-9 activity, mRNA levels, and promoter activity; and in Akt phosphorylation at Ser473. HMGA1 overexpression–induced increases in invasiveness were MMP-9 dependent. The role of phosphatidylinositol-3 kinase (PI3K)/Akt in mediating HMGA1-dependent invasiveness was elucidated by a specific PI3K inhibitor (LY294002) and constitutively active and dominant-negative Akt adenoviral constructs. Akt-dependent modulation of MMP-9 activity contributed significantly to HMGA1 overexpression–induced increases in invasive capacity. Furthermore, HMGA1 silencing resulted in reductions in metastatic potential and tumor growth in vivo and in tumoral MMP-9 activity. Our findings suggest that HMGA1 may be a novel molecular determinant of invasiveness and metastasis, as well as a potential therapeutic target, in pancreatic adenocarcinoma. (Cancer Res 2006; 66(24): 11613-22)" @default.
• W2135508788 created "2016-06-24" @default.
• W2135508788 creator A5030016408 @default.
• W2135508788 creator A5072328168 @default.
• W2135508788 creator A5088409317 @default.
• W2135508788 date "2006-12-15" @default.
• W2135508788 modified "2023-09-25" @default.
• W2135508788 title "HMGA1 Is a Determinant of Cellular Invasiveness and <i>In vivo</i> Metastatic Potential in Pancreatic Adenocarcinoma" @default.
• W2135508788 cites W1503337666 @default.
• W2135508788 cites W1548068969 @default.
• W2135508788 cites W1585517331 @default.
• W2135508788 cites W1963592300 @default.
• W2135508788 cites W1983429529 @default.
• W2135508788 cites W1997767982 @default.
• W2135508788 cites W2004911872 @default.
• W2135508788 cites W2006221754 @default.
• W2135508788 cites W2016136785 @default.
• W2135508788 cites W2016285151 @default.
• W2135508788 cites W2020506786 @default.
• W2135508788 cites W2027719459 @default.
• W2135508788 cites W2046728528 @default.
• W2135508788 cites W2048498664 @default.
• W2135508788 cites W2048537883 @default.
• W2135508788 cites W2053464363 @default.
• W2135508788 cites W2058680737 @default.
• W2135508788 cites W2059973463 @default.
• W2135508788 cites W2071531606 @default.
• W2135508788 cites W2072470895 @default.
• W2135508788 cites W2074457423 @default.
• W2135508788 cites W2075165827 @default.
• W2135508788 cites W2079054128 @default.
• W2135508788 cites W2079537922 @default.
• W2135508788 cites W2081807421 @default.
• W2135508788 cites W2081939209 @default.
• W2135508788 cites W2082163698 @default.
• W2135508788 cites W2082378283 @default.
• W2135508788 cites W2084975988 @default.
• W2135508788 cites W2095151181 @default.
• W2135508788 cites W2097002113 @default.
• W2135508788 cites W2113368345 @default.
• W2135508788 cites W2115235864 @default.
• W2135508788 cites W2128562119 @default.
• W2135508788 cites W2128903974 @default.
• W2135508788 cites W2133271589 @default.
• W2135508788 cites W2134410622 @default.
• W2135508788 cites W2160746910 @default.
• W2135508788 cites W2163809391 @default.
• W2135508788 cites W2167758528 @default.
• W2135508788 doi "https://doi.org/10.1158/0008-5472.can-06-1460" @default.
• W2135508788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17178855" @default.
• W2135508788 hasPublicationYear "2006" @default.
• W2135508788 type Work @default.
• W2135508788 sameAs 2135508788 @default.
• W2135508788 citedByCount "94" @default.
• W2135508788 countsByYear W21355087882012 @default.
• W2135508788 countsByYear W21355087882013 @default.
• W2135508788 countsByYear W21355087882014 @default.
• W2135508788 countsByYear W21355087882015 @default.
• W2135508788 countsByYear W21355087882016 @default.
• W2135508788 countsByYear W21355087882017 @default.
• W2135508788 countsByYear W21355087882018 @default.
• W2135508788 countsByYear W21355087882019 @default.
• W2135508788 countsByYear W21355087882020 @default.
• W2135508788 countsByYear W21355087882021 @default.
• W2135508788 countsByYear W21355087882022 @default.
• W2135508788 countsByYear W21355087882023 @default.
• W2135508788 crossrefType "journal-article" @default.
• W2135508788 hasAuthorship W2135508788A5030016408 @default.
• W2135508788 hasAuthorship W2135508788A5072328168 @default.
• W2135508788 hasAuthorship W2135508788A5088409317 @default.
• W2135508788 hasBestOaLocation W21355087881 @default.
• W2135508788 hasConcept C104317684 @default.
• W2135508788 hasConcept C119056186 @default.
• W2135508788 hasConcept C11960822 @default.
• W2135508788 hasConcept C121608353 @default.
• W2135508788 hasConcept C2779013556 @default.
• W2135508788 hasConcept C2780210213 @default.
• W2135508788 hasConcept C502942594 @default.
• W2135508788 hasConcept C54355233 @default.
• W2135508788 hasConcept C55493867 @default.
• W2135508788 hasConcept C62478195 @default.
• W2135508788 hasConcept C75217442 @default.
• W2135508788 hasConcept C86554907 @default.
• W2135508788 hasConcept C86803240 @default.
• W2135508788 hasConcept C95444343 @default.
• W2135508788 hasConceptScore W2135508788C104317684 @default.
• W2135508788 hasConceptScore W2135508788C119056186 @default.
• W2135508788 hasConceptScore W2135508788C11960822 @default.
• W2135508788 hasConceptScore W2135508788C121608353 @default.
• W2135508788 hasConceptScore W2135508788C2779013556 @default.
• W2135508788 hasConceptScore W2135508788C2780210213 @default.
• W2135508788 hasConceptScore W2135508788C502942594 @default.
• W2135508788 hasConceptScore W2135508788C54355233 @default.
• W2135508788 hasConceptScore W2135508788C55493867 @default.
• W2135508788 hasConceptScore W2135508788C62478195 @default.
• W2135508788 hasConceptScore W2135508788C75217442 @default.
• W2135508788 hasConceptScore W2135508788C86554907 @default.
• W2135508788 hasConceptScore W2135508788C86803240 @default.

• next