Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135546481> ?p ?o ?g. }
- W2135546481 endingPage "6153" @default.
- W2135546481 startingPage "6147" @default.
- W2135546481 abstract "ABSTRACT In addition to eliciting antigen specific T-cell-mediated immunity, Cryptococcus neoformans possesses a mitogen (CnM) that activates naive T cells to proliferate. This mechanism of T-cell activation is accessory cell dependent and major histocompatibility complex unrestricted. CnM-induced T-cell proliferation correlates with internalization of the organism, suggesting that intracellular processing is required to liberate CnM prior to presentation to T cells. To determine whether phagocytosis and processing are required, various inhibitors of accessory cell uptake and processing were used. C. neoformans was observed within the accessory cells. Paraformaldehyde fixation of the accessory cell abrogated presentation of CnM to T cells, indicating that a dynamic accessory cell surface was required. A lysosomotropic agent abrogated the response to CnM but had no effect on a control stimulus that did not require processing. Both aspartic acid and cysteine protease inhibitors blocked effective processing of CnM, so that it was unable to stimulate T cells. Finally, an inhibitor of microfilament polymerization abrogated proliferation to CnM. These results indicate that the mitogenic activity of C. neoformans requires phagocytosis of the organism, lysosomal or endosomal processing, proteolytic activity, and microfilament polymerization and intracellular transport as a prerequisite for T-cell proliferation." @default.
- W2135546481 created "2016-06-24" @default.
- W2135546481 creator A5011184057 @default.
- W2135546481 creator A5015363285 @default.
- W2135546481 creator A5037650050 @default.
- W2135546481 creator A5079429780 @default.
- W2135546481 creator A5090799386 @default.
- W2135546481 date "2000-11-01" @default.
- W2135546481 modified "2023-10-17" @default.
- W2135546481 title "Phagocytosis and Protein Processing Are Required for Presentation of <i>Cryptococcus neoformans</i> Mitogen to T Lymphocytes" @default.
- W2135546481 cites W174352674 @default.
- W2135546481 cites W1760686898 @default.
- W2135546481 cites W1894665538 @default.
- W2135546481 cites W1911197169 @default.
- W2135546481 cites W1912169188 @default.
- W2135546481 cites W1949461470 @default.
- W2135546481 cites W1967007006 @default.
- W2135546481 cites W1972463980 @default.
- W2135546481 cites W1974061274 @default.
- W2135546481 cites W1986755460 @default.
- W2135546481 cites W1988832398 @default.
- W2135546481 cites W1992577200 @default.
- W2135546481 cites W2002442463 @default.
- W2135546481 cites W2020281512 @default.
- W2135546481 cites W2022188569 @default.
- W2135546481 cites W2026506499 @default.
- W2135546481 cites W2028027014 @default.
- W2135546481 cites W2041401145 @default.
- W2135546481 cites W2047299081 @default.
- W2135546481 cites W2048469310 @default.
- W2135546481 cites W2061644948 @default.
- W2135546481 cites W2068606947 @default.
- W2135546481 cites W2075887210 @default.
- W2135546481 cites W2084788260 @default.
- W2135546481 cites W2086870995 @default.
- W2135546481 cites W2088498981 @default.
- W2135546481 cites W2097858152 @default.
- W2135546481 cites W2099893709 @default.
- W2135546481 cites W2102113761 @default.
- W2135546481 cites W2106521162 @default.
- W2135546481 cites W2106851545 @default.
- W2135546481 cites W2110308902 @default.
- W2135546481 cites W2118523249 @default.
- W2135546481 cites W2137137493 @default.
- W2135546481 cites W2145734455 @default.
- W2135546481 cites W2147251439 @default.
- W2135546481 cites W2150547274 @default.
- W2135546481 cites W2152280976 @default.
- W2135546481 cites W2161258469 @default.
- W2135546481 cites W2256778289 @default.
- W2135546481 cites W2267516419 @default.
- W2135546481 doi "https://doi.org/10.1128/iai.68.11.6147-6153.2000" @default.
- W2135546481 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/97692" @default.
- W2135546481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11035718" @default.
- W2135546481 hasPublicationYear "2000" @default.
- W2135546481 type Work @default.
- W2135546481 sameAs 2135546481 @default.
- W2135546481 citedByCount "24" @default.
- W2135546481 countsByYear W21355464812012 @default.
- W2135546481 countsByYear W21355464812013 @default.
- W2135546481 countsByYear W21355464812014 @default.
- W2135546481 countsByYear W21355464812015 @default.
- W2135546481 countsByYear W21355464812016 @default.
- W2135546481 countsByYear W21355464812017 @default.
- W2135546481 countsByYear W21355464812018 @default.
- W2135546481 crossrefType "journal-article" @default.
- W2135546481 hasAuthorship W2135546481A5011184057 @default.
- W2135546481 hasAuthorship W2135546481A5015363285 @default.
- W2135546481 hasAuthorship W2135546481A5037650050 @default.
- W2135546481 hasAuthorship W2135546481A5079429780 @default.
- W2135546481 hasAuthorship W2135546481A5090799386 @default.
- W2135546481 hasBestOaLocation W21355464812 @default.
- W2135546481 hasConcept C108249834 @default.
- W2135546481 hasConcept C142669718 @default.
- W2135546481 hasConcept C1491633281 @default.
- W2135546481 hasConcept C160448771 @default.
- W2135546481 hasConcept C161478664 @default.
- W2135546481 hasConcept C189040839 @default.
- W2135546481 hasConcept C203014093 @default.
- W2135546481 hasConcept C2776090121 @default.
- W2135546481 hasConcept C2777893358 @default.
- W2135546481 hasConcept C55493867 @default.
- W2135546481 hasConcept C79879829 @default.
- W2135546481 hasConcept C83464605 @default.
- W2135546481 hasConcept C86803240 @default.
- W2135546481 hasConcept C8891405 @default.
- W2135546481 hasConcept C89423630 @default.
- W2135546481 hasConcept C95444343 @default.
- W2135546481 hasConceptScore W2135546481C108249834 @default.
- W2135546481 hasConceptScore W2135546481C142669718 @default.
- W2135546481 hasConceptScore W2135546481C1491633281 @default.
- W2135546481 hasConceptScore W2135546481C160448771 @default.
- W2135546481 hasConceptScore W2135546481C161478664 @default.
- W2135546481 hasConceptScore W2135546481C189040839 @default.
- W2135546481 hasConceptScore W2135546481C203014093 @default.
- W2135546481 hasConceptScore W2135546481C2776090121 @default.
- W2135546481 hasConceptScore W2135546481C2777893358 @default.
- W2135546481 hasConceptScore W2135546481C55493867 @default.