Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135570562> ?p ?o ?g. }
- W2135570562 endingPage "665" @default.
- W2135570562 startingPage "653" @default.
- W2135570562 abstract "Immunoglobulin class switch recombination (CSR) is initiated by a B-cell-specific factor, activation-induced deaminase, probably through deamination of deoxycytidine residues within the switch (S) regions. The initial lesions in the S regions are subsequently processed, resulting in the production of DNA double-strand breaks (DSBs). These breaks will then be recognized, edited and repaired, finally leading to the recombination of the two S regions. Two major repair pathways have been implicated in CSR, the predominant non-homologous end joining (NHEJ) and the alternative end-joining (A-EJ) pathways. The former requires not only components of the ‘classical’ NHEJ machinery, i.e. Ku70/Ku80, DNA-dependent protein kinase catalytic subunit, DNA ligase IV and XRCC4, but also a number of DNA-damage sensors or adaptors, such as ataxia–telangiectasia mutated, γH2AX, 53BP1, MDC1, the Mre11–Rad50–NBS1 complex and the ataxia telangiectasia and Rad3-related protein (ATR). The latter pathway is not well characterized yet and probably requires microhomologies. In this review, we will focus on the current knowledge of the predominant NHEJ pathway in CSR and will also give a perspective on the A-EJ pathway." @default.
- W2135570562 created "2016-06-24" @default.
- W2135570562 creator A5041283342 @default.
- W2135570562 creator A5041739992 @default.
- W2135570562 creator A5054472483 @default.
- W2135570562 creator A5054788593 @default.
- W2135570562 creator A5061716968 @default.
- W2135570562 date "2008-11-13" @default.
- W2135570562 modified "2023-10-16" @default.
- W2135570562 title "Non-homologous end joining in class switch recombination: the beginning of the end" @default.
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