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• W2135575116 abstract "Premature activation of the inflammatory processes that mediate human parturition leads to preterm birth, a major clinical problem associated with neonatal morbidity and mortality. Histone deacetylase inhibitors (HDACi) are currently in clinical trials for the treatment of inflammatory disorders. Recent evidence suggests that there may be a therapeutic use for HDACi in the management of preterm birth, with administration of HDACi to pregnant mice shown to delay delivery. Because NF-κB is a key orchestrator of the inflammatory response and plays a pivotal role in parturition, it is important to understand how administration of HDACi might affect NF-κB activity in human uterine tissues. We show here that the effects of HDACi on nuclear factor-κB (NF-κB) in human myometrial cells are time-dependent. Short-term exposure to HDACi enhanced interleukin (IL)-1β-induced NF-κB activity as a result of potentiating IκB kinase (IKK)β activity, thereby leading to persistent turnover of IκBα/ϵ proteins and prolonging NF-κB phosphorylation, nuclear localization, and DNA binding. Conversely, long-term HDACi treatments resulted in repression of NF-κB DNA binding. Nevertheless, both short- and long-term HDACi treatments inhibited the expression of four labor-associated proinflammatory genes (<i>COX-2</i>, <i>IL-8</i>, <i>IL-6</i>, and <i>RANTES</i>), and this was associated with repression of the proinflammatory transcription factor c-Jun. Together, our data indicate that HDACi exert anti-inflammatory effects in human myometrium and may thus be useful in achieving a myometrial gene expression profile that favors uterine quiescence. However, coadministration of an IKKβ inhibitor may be both necessary and sufficient to circumvent potential induction of labor-associated pathways that could result from HDACi-induced augmentation of NF-κB activity." @default.
• W2135575116 created "2016-06-24" @default.
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• W2135575116 date "2008-03-28" @default.
• W2135575116 modified "2023-10-17" @default.
• W2135575116 title "Histone Deacetylase Inhibitors Exert Time-Dependent Effects on Nuclear Factor-κB but Consistently Suppress the Expression of Proinflammatory Genes in Human Myometrial Cells" @default.
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• W2135575116 doi "https://doi.org/10.1124/mol.107.042838" @default.
• W2135575116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18375836" @default.
• W2135575116 hasPublicationYear "2008" @default.
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