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- W2135585445 abstract "During B cell differentiation, the pre-B cell stage plays a significant role in immunoglobulin gene rearrangement in the context of the allelic exclusion and χ chain gene rearrangement. We previously reported that the early B cell-specific binding protein (EBB)-1 transcription factor binds to the promoters of two pre-B cell-specific genes, VpreB and λ5, and regulates their pre-B cell-specific expression. Here, we demonstrate that EBB-1 binds to the KI and KII sites in the upstream of Jχ region, which are crucial for χ chain gene rearrangement. Gene transfer and gel-shift assays demonstrate that EBB-1 is identical to Pax-5 and binds to promoters of VpreB and λ5 as well as the KI and KII sites. Our results suggest that Pax-5 plays an important role in the coordinate regulation of several immunoglobulin gene family members that are crucial in B cell development." @default.
- W2135585445 created "2016-06-24" @default.
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- W2135585445 date "1997-03-01" @default.
- W2135585445 modified "2023-10-16" @default.
- W2135585445 title "Pax-5 is identical to EBB-1/KLP and binds to the VpreB and λ5 promoters as well as the KI and KII sites upstream of the Jχ genes" @default.
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- W2135585445 doi "https://doi.org/10.1002/eji.1830270325" @default.
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