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• W2135593313 abstract "ABSTRACT We observed vitamin B 12 -mediated growth inhibition of Mycobacterium tuberculosis strain CDC1551. The B 12 sensitivity was mapped to a polymorphism in metH , encoding a coenzyme B 12 -dependent methionine synthase. Vitamin B 12 -resistant suppressor mutants of CDC1551 containing mutations in a B 12 riboswitch upstream of the metE gene, which encodes a B 12 -independent methionine synthase, were isolated. Expression analysis confirmed that the B 12 riboswitch is a transcriptional regulator of metE in M. tuberculosis ." @default.
• W2135593313 created "2016-06-24" @default.
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• W2135593313 date "2007-05-01" @default.
• W2135593313 modified "2023-09-27" @default.
• W2135593313 title "A Riboswitch Regulates Expression of the Coenzyme B ₁₂ -Independent Methionine Synthase in <i>Mycobacterium tuberculosis</i> : Implications for Differential Methionine Synthase Function in Strains H37Rv and CDC1551" @default.
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• W2135593313 doi "https://doi.org/10.1128/jb.00040-07" @default.
• W2135593313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1855906" @default.
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