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• W2135608449 abstract "A biomimetic hydrogel platform was designed to signal encapsulated cells using immobilized cell–cell communication cues, with a focus on enhancing the survival and function of encapsulated pancreatic β-cells to treat type 1 diabetes. When MIN6 cells, a pancreatic β-cell line, were encapsulated in poly(ethylene glycol) (PEG) hydrogels, their survival and glucose responsiveness to insulin were highly dependent on the cell-packing density. A minimum packing density of 10 7 cells/mL was necessary to maintain the survival of encapsulated β-cells without the addition of material functionalities (e.g., cell adhesion ligands). While single cell suspensions can improve diffusion-limited mass transfer, direct cell–cell interactions are limited. Thus, thiolated EphA5-Fc receptor and ephrinA5-Fc ligand were conjugated into PEG hydrogels via a thiol-acrylate photopolymerization to render an otherwise inert PEG hydrogel bioactive. The biomimetic hydrogels presented here can provide crucial cell–cell communication signals for dispersed β-cells and improve their survival and proliferation. Together with the cell-adhesive peptide RGDS, the immobilized fusion proteins (EphA5-Fc and ephrinA5-Fc) synergistically increased the survival of both MIN6 β-cells and dissociated islet cells, both at a very low cell-packing density (< 2 × 10 6 cells/mL). This unique gel platform demonstrates new strategies for tailoring biomimetic environments to enhance the encapsulation of cells that require cell–cell contact to survive and function." @default.
• W2135608449 created "2016-06-24" @default.
• W2135608449 creator A5019613511 @default.
• W2135608449 creator A5037165431 @default.
• W2135608449 date "2011-04-04" @default.
• W2135608449 modified "2023-10-14" @default.
• W2135608449 title "Cell–cell communication mimicry with poly(ethylene glycol) hydrogels for enhancing β-cell function" @default.
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• W2135608449 doi "https://doi.org/10.1073/pnas.1014026108" @default.
• W2135608449 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3080983" @default.
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