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• W2135610078 abstract "ABSTRACT Helicobacter cinaedi colonizes a wide host range, including rodents, and may be an emerging zoonotic agent. Colonization parameters, pathology, serology, and inflammatory responses to wild-type H. cinaedi (WT Hc ) were evaluated in B6.129P2- IL-10 tm1Cgn (IL-10 −/− ) mice for 36 weeks postinfection (WPI) and in C57BL/6 (B6) mice for 12 WPI. Because cytolethal distending toxin (CDT) may be a virulence factor, IL-10 −/− mice were also infected with the cdtB Hc and cdtB -N Hc isogenic mutants and evaluated for 12 WPI. Consistent with other murine enterohepatic helicobacters, WT Hc did not cause typhlocolitis in B6 mice, but mild to severe lesions developed at the cecocolic junction in IL-10 −/− mice, despite similar colonization levels of WT Hc in the cecum and colon of both B6 and IL-10 −/− mice. WT Hc and cdtB mutants also colonized IL-10 −/− mice to a similar extent, but infection with either cdtB mutant resulted in attenuated typhlocolitis and hyperplasia compared to infection with WT Hc ( P < 0.03), and only WT Hc infection caused dysplasia and intramucosal carcinoma. WT Hc and cdtB Hc mutant infection of IL-10 −/− mice elevated mRNA expression of tumor necrosis factor alpha, inducible nitric oxide synthase, and gamma interferon in the cecum, as well as elevated Th1-associated serum immunoglobulin G2a b compared to infection of B6 mice ( P < 0.05). Although no hepatitis was noted, liver samples were PCR positive at various time points for WT Hc or the cdtB Hc mutant in approximately 33% of IL-10 −/− mice and in 10 to 20% of WT Hc -infected B6 mice. These results indicate that WT Hc can be used to model inflammatory bowel disease in IL-10 −/− mice and that CDT contributes to the virulence of H. cinaedi ." @default.
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• W2135610078 date "2009-06-01" @default.
• W2135610078 modified "2023-09-23" @default.
• W2135610078 title "Cytolethal Distending Toxin Promotes <i>Helicobacter cinaedi</i> -Associated Typhlocolitis in Interleukin-10-Deficient Mice" @default.
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• W2135610078 doi "https://doi.org/10.1128/iai.00166-09" @default.
• W2135610078 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2687359" @default.
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