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• W2135620943 abstract "Maturation of polyspecific B cells to Ig secretion was induced in response to the interaction of helper T cells with soluble antigen. The in vitro propagated, keyhole limpet hemocyanin (KLH)-primed C57BL16 T cells used in these experiments proliferated in response to antigen presented on I-A-compatible antigen-presenting cells and were depleted of alloreactive cells. These T cells induced a strong polyspecific plaque-forming cell response from normal C57BL/6 B cells over a wide range of KLH concentrations (100 μg/ml to 0.01 μg/ml). Culture conditions were established whereby H-2-restricted T cell-macrophage interactions were nonlimiting, allowing a direct analysis of H-2-restricted T-B cell interactions involved in polyspecific B cell induction. The requirements for B cell induction/amplification were dependent on the size of the responding B cell population. Small B cells were activated only at high concentrations of KLH and required a direct H-2-restricted interaction with KLH-primed helper T cells. In contrast, large B cells were induced/amplified over the full range of KLH concentrations tested in an H-2-unrestricted manner, limited only by the H-2-restricted, antigen-dependent activation of T helper cells. The requirement for high antigen concentration in the activation of small B cells is proposed to reflect a requirement for antigen binding to the B cell surface via nonspecific interactions. This binding was not in itself stimulatory, but expression of antigen in conjunction with B cell surface Ia antigens provided a focus for a direct interaction with Ia-restricted, antigen-specific T helper cells (or factors). In contrast, the H-2-unrestricted induction/ amplification of large B cells was mediated solely as a consequence of the helper T cell activation which occurred at the lowest concentrations of KLH tested. T helper cell activation is proposed to lead to the production of non-antigen-specific, non-Ia-restricted factors supporting the continued growth of blasted B cells. Thus, while an H-2-restricted T cell-macrophage interaction is an obligate requirement for polyspecific B cell responses, the requirement for a direct H-2-restricted T-B cell interaction varies with the pre-existing state of activation of the responding B cell population." @default.
• W2135620943 created "2016-06-24" @default.
• W2135620943 creator A5074551684 @default.
• W2135620943 creator A5087421876 @default.
• W2135620943 date "1982-01-01" @default.
• W2135620943 modified "2023-09-27" @default.
• W2135620943 title "H-2-restricted T-B cell interactions involved in polyspecific B cell responses mediated by soluble antigen" @default.
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• W2135620943 doi "https://doi.org/10.1002/eji.1830120803" @default.
• W2135620943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6982814" @default.
• W2135620943 hasPublicationYear "1982" @default.
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