Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135624863> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2135624863 endingPage "1452" @default.
- W2135624863 startingPage "1449" @default.
- W2135624863 abstract "To determine the relationship between erythrocyte and plasma ribavirin concentrations in hepatitis C virus (HCV)/HIV-coinfected patients, and to correlate ribavirin exposure with early and sustained virological response (EVR and SVR) and haemoglobin level reductions.Clinical and biological data from 68 HCV/HIV-coinfected patients were recorded at baseline, week 4 (W4), week 12 and at 24 weeks after completion of treatment. Plasma and erythrocyte ribavirin concentrations were determined 12 h after the final ribavirin dose (C(min)).Erythrocyte ribavirin concentrations were 100-fold higher than plasma concentrations, with a significant relationship between them (P < 0.05). In patients with HCV genotype 1 or 4, a plasma ribavirin C(min) threshold of 1.95 mg/L at W4 tended to predict EVR [sensitivity 44%; specificity 87%; AUC 0.67 (95% CI 0.50-0.84)] and was predictive of SVR [sensitivity 58%; specificity 84%; AUC 0.71 (95% CI 0.51-0.90)]. Among patients with these HCV genotypes, an erythrocyte ribavirin C(min) threshold of 146 mg/L at W4 was found to be the best value for discriminating between responders and non-responders for both EVR [sensitivity 67%; specificity 75%; AUC 0.58 (95% CI 0.24-0.93)] and SVR [sensitivity 50%; specificity 80%; AUC 0.70 (95% CI 0.39-1.01)]. We also demonstrated a significant relationship between reduced haemoglobin levels and plasma ribavirin C(min) at W4 (P = 0.05).Therapeutic drug monitoring may be useful for the management of anti-HCV treatment in HCV/HIV-coinfected patients." @default.
- W2135624863 created "2016-06-24" @default.
- W2135624863 creator A5005368354 @default.
- W2135624863 creator A5017386021 @default.
- W2135624863 creator A5029770079 @default.
- W2135624863 creator A5031382919 @default.
- W2135624863 creator A5042457665 @default.
- W2135624863 creator A5044039450 @default.
- W2135624863 creator A5045396101 @default.
- W2135624863 creator A5061527531 @default.
- W2135624863 creator A5079327362 @default.
- W2135624863 creator A5081353121 @default.
- W2135624863 creator A5082424239 @default.
- W2135624863 date "2012-03-05" @default.
- W2135624863 modified "2023-10-16" @default.
- W2135624863 title "Erythrocyte and plasma ribavirin concentrations in the assessment of early and sustained virological responses to pegylated interferon-alpha 2a and ribavirin in patients coinfected with hepatitis C virus and HIV" @default.
- W2135624863 cites W1986766693 @default.
- W2135624863 cites W1993484328 @default.
- W2135624863 cites W2003641083 @default.
- W2135624863 cites W2014150111 @default.
- W2135624863 cites W2015659508 @default.
- W2135624863 cites W2103707468 @default.
- W2135624863 cites W2131491481 @default.
- W2135624863 cites W2146121203 @default.
- W2135624863 cites W2160930473 @default.
- W2135624863 doi "https://doi.org/10.1093/jac/dks045" @default.
- W2135624863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22396433" @default.
- W2135624863 hasPublicationYear "2012" @default.
- W2135624863 type Work @default.
- W2135624863 sameAs 2135624863 @default.
- W2135624863 citedByCount "10" @default.
- W2135624863 countsByYear W21356248632013 @default.
- W2135624863 countsByYear W21356248632014 @default.
- W2135624863 countsByYear W21356248632015 @default.
- W2135624863 countsByYear W21356248632018 @default.
- W2135624863 countsByYear W21356248632020 @default.
- W2135624863 crossrefType "journal-article" @default.
- W2135624863 hasAuthorship W2135624863A5005368354 @default.
- W2135624863 hasAuthorship W2135624863A5017386021 @default.
- W2135624863 hasAuthorship W2135624863A5029770079 @default.
- W2135624863 hasAuthorship W2135624863A5031382919 @default.
- W2135624863 hasAuthorship W2135624863A5042457665 @default.
- W2135624863 hasAuthorship W2135624863A5044039450 @default.
- W2135624863 hasAuthorship W2135624863A5045396101 @default.
- W2135624863 hasAuthorship W2135624863A5061527531 @default.
- W2135624863 hasAuthorship W2135624863A5079327362 @default.
- W2135624863 hasAuthorship W2135624863A5081353121 @default.
- W2135624863 hasAuthorship W2135624863A5082424239 @default.
- W2135624863 hasBestOaLocation W21356248631 @default.
- W2135624863 hasConcept C126322002 @default.
- W2135624863 hasConcept C159047783 @default.
- W2135624863 hasConcept C203014093 @default.
- W2135624863 hasConcept C2522874641 @default.
- W2135624863 hasConcept C2776178377 @default.
- W2135624863 hasConcept C2776408679 @default.
- W2135624863 hasConcept C2776455275 @default.
- W2135624863 hasConcept C2776461080 @default.
- W2135624863 hasConcept C2780040827 @default.
- W2135624863 hasConcept C2909179924 @default.
- W2135624863 hasConcept C71924100 @default.
- W2135624863 hasConcept C90924648 @default.
- W2135624863 hasConceptScore W2135624863C126322002 @default.
- W2135624863 hasConceptScore W2135624863C159047783 @default.
- W2135624863 hasConceptScore W2135624863C203014093 @default.
- W2135624863 hasConceptScore W2135624863C2522874641 @default.
- W2135624863 hasConceptScore W2135624863C2776178377 @default.
- W2135624863 hasConceptScore W2135624863C2776408679 @default.
- W2135624863 hasConceptScore W2135624863C2776455275 @default.
- W2135624863 hasConceptScore W2135624863C2776461080 @default.
- W2135624863 hasConceptScore W2135624863C2780040827 @default.
- W2135624863 hasConceptScore W2135624863C2909179924 @default.
- W2135624863 hasConceptScore W2135624863C71924100 @default.
- W2135624863 hasConceptScore W2135624863C90924648 @default.
- W2135624863 hasIssue "6" @default.
- W2135624863 hasLocation W21356248631 @default.
- W2135624863 hasLocation W21356248632 @default.
- W2135624863 hasOpenAccess W2135624863 @default.
- W2135624863 hasPrimaryLocation W21356248631 @default.
- W2135624863 hasRelatedWork W1911438026 @default.
- W2135624863 hasRelatedWork W1986416046 @default.
- W2135624863 hasRelatedWork W1994642708 @default.
- W2135624863 hasRelatedWork W2014150111 @default.
- W2135624863 hasRelatedWork W2018481937 @default.
- W2135624863 hasRelatedWork W2031380552 @default.
- W2135624863 hasRelatedWork W2059421866 @default.
- W2135624863 hasRelatedWork W2086414517 @default.
- W2135624863 hasRelatedWork W2106122464 @default.
- W2135624863 hasRelatedWork W2159449285 @default.
- W2135624863 hasVolume "67" @default.
- W2135624863 isParatext "false" @default.
- W2135624863 isRetracted "false" @default.
- W2135624863 magId "2135624863" @default.
- W2135624863 workType "article" @default.