Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135625713> ?p ?o ?g. }
- W2135625713 endingPage "204" @default.
- W2135625713 startingPage "193" @default.
- W2135625713 abstract "Cancer is a leading cause of death in the United States. Angiogenesis inhibitors have been introduced for the treatment of cancer. Based on the fact that many anticancer agents have been developed from botanical sources, there is a significant untapped resource to be found in natural products. American ginseng is a commonly used herbal medicine in the U.S., which possesses antioxidant properties. After oral ingestion, natural ginseng saponins are biotransformed to their metabolites by the enteric microbiome before being absorbed. The major metabolites, ginsenoside Rg3 and compound K, showed significant potent anticancer activity compared to that of their parent ginsenosides Rb1, Rc, and Rd. In this review, the molecular mechanisms of ginseng metabolites on cancer chemoprevention, especially apoptosis and angiogenic inhibition, are discussed. Ginseng gut microbiome metabolites showed significant anti-angiogenic effects on pulmonary, gastric and ovarian cancers. This review suggests that in addition to the chemopreventive effects of ginseng compounds, as angiogenic inhibitors, ginsenoside metabolites could be used in combination with other cancer chemotherapeutic agents in cancer management." @default.
- W2135625713 created "2016-06-24" @default.
- W2135625713 creator A5020423570 @default.
- W2135625713 creator A5053927760 @default.
- W2135625713 creator A5075669369 @default.
- W2135625713 creator A5087125305 @default.
- W2135625713 date "2015-09-02" @default.
- W2135625713 modified "2023-10-14" @default.
- W2135625713 title "Ginseng Metabolites on Cancer Chemoprevention: An Angiogenesis Link?" @default.
- W2135625713 cites W1965180872 @default.
- W2135625713 cites W1968045613 @default.
- W2135625713 cites W1968778093 @default.
- W2135625713 cites W1969075192 @default.
- W2135625713 cites W1973374931 @default.
- W2135625713 cites W1974044407 @default.
- W2135625713 cites W1975714310 @default.
- W2135625713 cites W1978138839 @default.
- W2135625713 cites W1979907716 @default.
- W2135625713 cites W1981058118 @default.
- W2135625713 cites W1986607628 @default.
- W2135625713 cites W1987713972 @default.
- W2135625713 cites W1990090167 @default.
- W2135625713 cites W1990119075 @default.
- W2135625713 cites W1992270353 @default.
- W2135625713 cites W1993434718 @default.
- W2135625713 cites W1993726050 @default.
- W2135625713 cites W1994760455 @default.
- W2135625713 cites W1996852003 @default.
- W2135625713 cites W1997691932 @default.
- W2135625713 cites W1998674850 @default.
- W2135625713 cites W2001546832 @default.
- W2135625713 cites W2006148921 @default.
- W2135625713 cites W2009821528 @default.
- W2135625713 cites W2010041719 @default.
- W2135625713 cites W2011113802 @default.
- W2135625713 cites W2012577479 @default.
- W2135625713 cites W2013913223 @default.
- W2135625713 cites W2016304906 @default.
- W2135625713 cites W2018578159 @default.
- W2135625713 cites W2021330396 @default.
- W2135625713 cites W2024465345 @default.
- W2135625713 cites W2024903578 @default.
- W2135625713 cites W2027006505 @default.
- W2135625713 cites W2043752864 @default.
- W2135625713 cites W2046401757 @default.
- W2135625713 cites W2047847066 @default.
- W2135625713 cites W2053108643 @default.
- W2135625713 cites W2054407742 @default.
- W2135625713 cites W2057967638 @default.
- W2135625713 cites W2059272234 @default.
- W2135625713 cites W2061967460 @default.
- W2135625713 cites W2064542285 @default.
- W2135625713 cites W2066595295 @default.
- W2135625713 cites W2067433108 @default.
- W2135625713 cites W2068169953 @default.
- W2135625713 cites W2068454518 @default.
- W2135625713 cites W2071934344 @default.
- W2135625713 cites W2075536570 @default.
- W2135625713 cites W2084951981 @default.
- W2135625713 cites W2089404136 @default.
- W2135625713 cites W2091728033 @default.
- W2135625713 cites W2094782932 @default.
- W2135625713 cites W2101997514 @default.
- W2135625713 cites W2102007289 @default.
- W2135625713 cites W2106331336 @default.
- W2135625713 cites W2108187125 @default.
- W2135625713 cites W2110235509 @default.
- W2135625713 cites W2110413597 @default.
- W2135625713 cites W2113587124 @default.
- W2135625713 cites W2114850456 @default.
- W2135625713 cites W2116144169 @default.
- W2135625713 cites W2117608682 @default.
- W2135625713 cites W2118213878 @default.
- W2135625713 cites W2122180759 @default.
- W2135625713 cites W2130544703 @default.
- W2135625713 cites W2134122811 @default.
- W2135625713 cites W2134708688 @default.
- W2135625713 cites W2139714284 @default.
- W2135625713 cites W2144929673 @default.
- W2135625713 cites W2147496620 @default.
- W2135625713 cites W2162810464 @default.
- W2135625713 cites W2169160308 @default.
- W2135625713 cites W2170552969 @default.
- W2135625713 cites W2170781836 @default.
- W2135625713 cites W2325636730 @default.
- W2135625713 cites W2327362588 @default.
- W2135625713 cites W2328023807 @default.
- W2135625713 cites W2418052735 @default.
- W2135625713 cites W4252851641 @default.
- W2135625713 cites W4361862908 @default.
- W2135625713 doi "https://doi.org/10.3390/diseases3030193" @default.
- W2135625713 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4773028" @default.
- W2135625713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26941993" @default.
- W2135625713 hasPublicationYear "2015" @default.
- W2135625713 type Work @default.
- W2135625713 sameAs 2135625713 @default.
- W2135625713 citedByCount "28" @default.
- W2135625713 countsByYear W21356257132016 @default.