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• W2135649725 endingPage "54" @default.
• W2135649725 startingPage "33" @default.
• W2135649725 abstract "Dendritic cells (DCs) are highly efficient antigen-presenting cells (APCs) that collect antigen in body tissues and transport them to draining lymph nodes. Antigenic peptides are loaded onto major histocompatibility complex (MHC) molecules for presentation to naive T cells, resulting in the induction of cellular and humoral immune responses. DCs take up antigen through phagocytosis, pinocytosis, and endocytosis via different groups of receptor families, such as Fc receptors for antigen-antibody complexes, C-type lectin receptors (CLRs) for glycoproteins, and pattern recognition receptors, such as Toll-like receptors (TLRs), for microbial antigens. Uptake of antigen by CLRs leads to presentation of antigens on MHC class I and II molecules. DCs are well equipped to distinguish between self- and nonself-antigens by the variable expression of cell-surface receptors such as CLRs and TLRs. In the steady state, DCs are not immunologically quiescent but use their antigen-handling capacities to maintain peripheral tolerance. DCs are continuously sampling and presenting self- and harmless environmental proteins to silence immune activation. Uptake of self-components in the intestine and airways are good examples of sites where continuous presentation of self- and foreign antigens occurs without immune activation. In contrast, efficient antigen-specific immune activation occurs upon encounter of DCs with nonself-pathogens. Recognition of pathogens by DCs triggers specific receptors such as TLRs that result in DC maturation and subsequently immune activation. Here we discuss the concept that cross talk between TLRs and CLRs, differentially expressed by subsets of DCs, accounts for the different pathways to peripheral tolerance, such as deletion and suppression, and immune activation." @default.
• W2135649725 created "2016-06-24" @default.
• W2135649725 creator A5009217310 @default.
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• W2135649725 creator A5036389128 @default.
• W2135649725 creator A5045424398 @default.
• W2135649725 creator A5078848017 @default.
• W2135649725 date "2004-04-01" @default.
• W2135649725 modified "2023-10-18" @default.
• W2135649725 title "Self- and Nonself-Recognition by C-Type Lectins on Dendritic Cells" @default.
• W2135649725 cites W1481511581 @default.
• W2135649725 cites W1490649014 @default.
• W2135649725 cites W1498929362 @default.
• W2135649725 cites W1510218059 @default.
• W2135649725 cites W1514540900 @default.
• W2135649725 cites W1519502779 @default.
• W2135649725 cites W1536595294 @default.
• W2135649725 cites W1540808432 @default.
• W2135649725 cites W1543888238 @default.
• W2135649725 cites W1550634531 @default.
• W2135649725 cites W1554027982 @default.
• W2135649725 cites W1564649778 @default.
• W2135649725 cites W1579536966 @default.
• W2135649725 cites W1661544713 @default.
• W2135649725 cites W1794218861 @default.
• W2135649725 cites W1955288634 @default.
• W2135649725 cites W1957213149 @default.
• W2135649725 cites W1963699631 @default.
• W2135649725 cites W1966778178 @default.
• W2135649725 cites W1969602339 @default.
• W2135649725 cites W1972261522 @default.
• W2135649725 cites W1980140633 @default.
• W2135649725 cites W1980272197 @default.
• W2135649725 cites W1987217273 @default.
• W2135649725 cites W1987756723 @default.
• W2135649725 cites W1988043125 @default.
• W2135649725 cites W1988940275 @default.
• W2135649725 cites W1990283625 @default.
• W2135649725 cites W1991369439 @default.
• W2135649725 cites W1991690755 @default.
• W2135649725 cites W1994603967 @default.
• W2135649725 cites W1995332691 @default.
• W2135649725 cites W1996736315 @default.
• W2135649725 cites W1999498760 @default.
• W2135649725 cites W2001614383 @default.
• W2135649725 cites W2012657759 @default.
• W2135649725 cites W2013857975 @default.
• W2135649725 cites W2016475905 @default.
• W2135649725 cites W2016861362 @default.
• W2135649725 cites W2018840987 @default.
• W2135649725 cites W2020436206 @default.
• W2135649725 cites W2023545075 @default.
• W2135649725 cites W2029565478 @default.
• W2135649725 cites W2031280438 @default.
• W2135649725 cites W2034570325 @default.
• W2135649725 cites W2036867505 @default.
• W2135649725 cites W2041704171 @default.
• W2135649725 cites W2044040790 @default.
• W2135649725 cites W2045384882 @default.
• W2135649725 cites W2045589130 @default.
• W2135649725 cites W2048465324 @default.
• W2135649725 cites W2052588752 @default.
• W2135649725 cites W2057513374 @default.
• W2135649725 cites W2062350041 @default.
• W2135649725 cites W2062494337 @default.
• W2135649725 cites W2062561488 @default.
• W2135649725 cites W2063029767 @default.
• W2135649725 cites W2067560247 @default.
• W2135649725 cites W2073228254 @default.
• W2135649725 cites W2077780541 @default.
• W2135649725 cites W2078781814 @default.
• W2135649725 cites W2086155380 @default.
• W2135649725 cites W2086173738 @default.
• W2135649725 cites W2087166273 @default.
• W2135649725 cites W2089298835 @default.
• W2135649725 cites W2090973041 @default.
• W2135649725 cites W2093329141 @default.
• W2135649725 cites W2093551242 @default.
• W2135649725 cites W2093828185 @default.
• W2135649725 cites W2096417058 @default.
• W2135649725 cites W2100350828 @default.
• W2135649725 cites W2101994976 @default.
• W2135649725 cites W2104904748 @default.
• W2135649725 cites W2105952229 @default.
• W2135649725 cites W2106945734 @default.
• W2135649725 cites W2107543562 @default.
• W2135649725 cites W2107625698 @default.
• W2135649725 cites W2109204917 @default.
• W2135649725 cites W2111695773 @default.
• W2135649725 cites W2116763454 @default.
• W2135649725 cites W2118001355 @default.
• W2135649725 cites W2118364979 @default.
• W2135649725 cites W2124270882 @default.
• W2135649725 cites W2126620985 @default.
• W2135649725 cites W2126924404 @default.
• W2135649725 cites W2127815795 @default.
• W2135649725 cites W2127954824 @default.
• W2135649725 cites W2129442719 @default.

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