FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135650665> ?p ?o ?g. }

• W2135650665 endingPage "153" @default.
• W2135650665 startingPage "148" @default.
• W2135650665 abstract "Objective To investigate the associations of a polymorphism in the intercellular adhesion molecule-1 (ICAM1) gene, and ICAM1 serum levels, with migraine and migraine subtypes in a Han Chinese population. Method We used PCR-restriction fragment length polymorphism (PCR–RFLP) and gene sequencing to analyze the genotype and allelic frequencies of the K469E (rs5498) and G241R (rs1799969) ICAM1 polymorphisms between migraine cases and controls. Serum levels of ICAM1 were tested by enzyme linked immunosorbent assay (ELISA). Results (1) We found significant higher frequencies of the distribution of the E/E genotype and the E allele of the K469E polymorphism between migraine cases and controls (χ2 = 4.948 & P < 0.05 and χ2 = 13.990 & P < 0.01, respectively), and between a migraine without aura subtype of migraine cases and controls (χ2 = 5.265 & P < 0.05; χ2 = 20.501 & P < 0.01, respectively). After correction by conditional logistical regression, the frequency distribution difference of the E/E genotype between the migraine cases and controls remained statistically significant (OR = 32.85, 95% CI:4.22–28.79, P = 0.007.) (2) ICAM1 serum levels were significantly higher in migraine cases than in controls (P < 0.01) and, within migraine cases, were significantly higher in K469E E allele carriers than in K allele carriers (P < 0.01). Conclusions Our data indicate that the E/E genotype of the ICAM1 K469E polymorphism may be an important risk factor for migraine in a Han Chinese population, and that this polymorphism affects ICAM1 serum levels. Although the independent risk factor constituted by this polymorphism in other ethnic groups requires further study, our studies raise the possibility of the development of ICAM1 K469E E allele-specific therapeutics for the prevention and treatment of migraine in the Chinese Han population." @default.
• W2135650665 created "2016-06-24" @default.
• W2135650665 creator A5000641418 @default.
• W2135650665 creator A5023143758 @default.
• W2135650665 creator A5026174200 @default.
• W2135650665 creator A5051478610 @default.
• W2135650665 creator A5053595979 @default.
• W2135650665 creator A5060280023 @default.
• W2135650665 creator A5089945220 @default.
• W2135650665 date "2014-10-01" @default.
• W2135650665 modified "2023-09-26" @default.
• W2135650665 title "Associations of a polymorphism in the intercellular adhesion molecule-1 (ICAM1) gene and ICAM1 serum levels with migraine in a Chinese Han population" @default.
• W2135650665 cites W1526236056 @default.
• W2135650665 cites W1815163311 @default.
• W2135650665 cites W1930900918 @default.
• W2135650665 cites W1960023303 @default.
• W2135650665 cites W1991717169 @default.
• W2135650665 cites W1993928669 @default.
• W2135650665 cites W1997555942 @default.
• W2135650665 cites W2001699192 @default.
• W2135650665 cites W2006383126 @default.
• W2135650665 cites W2009732792 @default.
• W2135650665 cites W2013989909 @default.
• W2135650665 cites W2017687313 @default.
• W2135650665 cites W2027475058 @default.
• W2135650665 cites W2034954568 @default.
• W2135650665 cites W2034958980 @default.
• W2135650665 cites W2056538507 @default.
• W2135650665 cites W2068924772 @default.
• W2135650665 cites W2075590650 @default.
• W2135650665 cites W2084423618 @default.
• W2135650665 cites W2094736587 @default.
• W2135650665 cites W2096457914 @default.
• W2135650665 cites W2101897222 @default.
• W2135650665 cites W2105044812 @default.
• W2135650665 cites W2122807651 @default.
• W2135650665 cites W2123322428 @default.
• W2135650665 cites W2151487996 @default.
• W2135650665 cites W2153264168 @default.
• W2135650665 cites W2154114188 @default.
• W2135650665 cites W2157333252 @default.
• W2135650665 cites W2330065073 @default.
• W2135650665 cites W4252146009 @default.
• W2135650665 doi "https://doi.org/10.1016/j.jns.2014.07.030" @default.
• W2135650665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25145994" @default.
• W2135650665 hasPublicationYear "2014" @default.
• W2135650665 type Work @default.
• W2135650665 sameAs 2135650665 @default.
• W2135650665 citedByCount "13" @default.
• W2135650665 countsByYear W21356506652015 @default.
• W2135650665 countsByYear W21356506652016 @default.
• W2135650665 countsByYear W21356506652017 @default.
• W2135650665 countsByYear W21356506652019 @default.
• W2135650665 countsByYear W21356506652020 @default.
• W2135650665 countsByYear W21356506652021 @default.
• W2135650665 countsByYear W21356506652022 @default.
• W2135650665 crossrefType "journal-article" @default.
• W2135650665 hasAuthorship W2135650665A5000641418 @default.
• W2135650665 hasAuthorship W2135650665A5023143758 @default.
• W2135650665 hasAuthorship W2135650665A5026174200 @default.
• W2135650665 hasAuthorship W2135650665A5051478610 @default.
• W2135650665 hasAuthorship W2135650665A5053595979 @default.
• W2135650665 hasAuthorship W2135650665A5060280023 @default.
• W2135650665 hasAuthorship W2135650665A5089945220 @default.
• W2135650665 hasConcept C104317684 @default.
• W2135650665 hasConcept C126322002 @default.
• W2135650665 hasConcept C134018914 @default.
• W2135650665 hasConcept C135763542 @default.
• W2135650665 hasConcept C149737253 @default.
• W2135650665 hasConcept C180754005 @default.
• W2135650665 hasConcept C203014093 @default.
• W2135650665 hasConcept C2776914184 @default.
• W2135650665 hasConcept C2778541695 @default.
• W2135650665 hasConcept C2908647359 @default.
• W2135650665 hasConcept C2909375385 @default.
• W2135650665 hasConcept C37463918 @default.
• W2135650665 hasConcept C54355233 @default.
• W2135650665 hasConcept C71924100 @default.
• W2135650665 hasConcept C76252995 @default.
• W2135650665 hasConcept C86803240 @default.
• W2135650665 hasConcept C90924648 @default.
• W2135650665 hasConcept C99454951 @default.
• W2135650665 hasConceptScore W2135650665C104317684 @default.
• W2135650665 hasConceptScore W2135650665C126322002 @default.
• W2135650665 hasConceptScore W2135650665C134018914 @default.
• W2135650665 hasConceptScore W2135650665C135763542 @default.
• W2135650665 hasConceptScore W2135650665C149737253 @default.
• W2135650665 hasConceptScore W2135650665C180754005 @default.
• W2135650665 hasConceptScore W2135650665C203014093 @default.
• W2135650665 hasConceptScore W2135650665C2776914184 @default.
• W2135650665 hasConceptScore W2135650665C2778541695 @default.
• W2135650665 hasConceptScore W2135650665C2908647359 @default.
• W2135650665 hasConceptScore W2135650665C2909375385 @default.
• W2135650665 hasConceptScore W2135650665C37463918 @default.
• W2135650665 hasConceptScore W2135650665C54355233 @default.
• W2135650665 hasConceptScore W2135650665C71924100 @default.
• W2135650665 hasConceptScore W2135650665C76252995 @default.
• W2135650665 hasConceptScore W2135650665C86803240 @default.

• next