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• W2135651837 startingPage "1272" @default.
• W2135651837 abstract "BackgroundFluoroquinolone resistance is common in Staphylococcus aureus is increasing in Streptococcus pneumoniae and is reported in Streptococcus pyogenes MethodsWe surveyed 384 clinical isolates of S. pyogenes isolated during 2002–2003, for susceptibility to ciprofloxacin. We performed nucleotide sequencing of the parC and gyrA genes and determined the M/emm type for selected isolates. Additionally, we analyzed M/emm type 6 S. pyogenes isolated during 1918–2003 from diverse locations ResultsOf the survey isolates, 10.9% had reduced zones of inhibition to ciprofloxacin in the disk-diffusion test and had elevated minimum inhibitory concentrations to other fluoroquinolones, compared with those of fully susceptible isolates. Of the resistant isolates, 90.5% were M/emm type 6, and all sequenced M/emm type 6 isolates contained a serine-to-alanine substitution at position 79 in parC. Strikingly, the same findings were also present in macrolide-resistant isolates from a recent outbreak of S. pyogenes infection in Pittsburgh and in the Lancefield reference strain of M type 6, which was isolated in 1918, decades before the development of fluoroquinolone antibiotics ConclusionM/emm type 6 S. pyogenes has intrinsic reduced susceptibility to fluoroquinolones, as a result of a polymorphism in parC. This finding was also demonstrated in erythromycin-resistant M/emm type 6 S. pyogenes which raises concern for the emergence of multidrug-resistant S. pyogenes" @default.
• W2135651837 created "2016-06-24" @default.
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• W2135651837 date "2005-04-15" @default.
• W2135651837 modified "2023-09-27" @default.
• W2135651837 title "Intrinsic Reduced Susceptibility of Serotype 6Streptococcus pyogenesto Fluoroquinolone Antibiotics" @default.
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• W2135651837 doi "https://doi.org/10.1086/428856" @default.
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• W2135651837 hasPublicationYear "2005" @default.
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