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• W2135655187 abstract "ABSTRACT We previously showed that adoptive transfer of Borrelia burgdorferi -pulsed dendritic cells (DCs) into syngeneic mice protects animals from challenge with tick-transmitted spirochetes. Here, we demonstrate that the protective immune response is antibody (Ab) dependent and does not require the presence of major histocompatibility complex (MHC) class II molecules on DCs. Mice sensitized with B. burgdorferi -pulsed MHC class II-deficient (MHC class II −/− ) DCs mounted a humoral response against protective antigens, including B. burgdorferi outer surface protein A (OspA) and OspC. B-cell help for the generation of neutralizing anti-OspC immunoglobulin G Abs could be provided by γδ T cells. In contrast, anti-OspA Ab production required the presence of αβ T cells, although this pathway could be independent of MHC class II molecules on antigen-presenting cells. Moreover, depletion of NK cells prior to transfer of antigen-pulsed MHC class II −/− DCs resulted in significant increases in the levels of neutralizing Abs induced by DCs. Altogether, these data suggest that the initial interactions between DCs and innate immune cells, such as γδ and NK cells, can influence the generation of a protective humoral response against B. burgdorferi antigens." @default.
• W2135655187 created "2016-06-24" @default.
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• W2135655187 date "2001-04-01" @default.
• W2135655187 modified "2023-09-25" @default.
• W2135655187 title "Major Histocompatibility Complex Class II-Independent Generation of Neutralizing Antibodies against T-Cell-Dependent <i>Borrelia burgdorferi</i> Antigens Presented by Dendritic Cells: Regulation by NK and γδ T Cells" @default.
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• W2135655187 doi "https://doi.org/10.1128/iai.69.4.2407-2415.2001" @default.
• W2135655187 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/98173" @default.
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