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• W2135655272 endingPage "R1087" @default.
• W2135655272 startingPage "R1078" @default.
• W2135655272 abstract "We hypothesized that increasing skeletal muscle total creatine (Cr) content through dietary Cr supplementation would result in slower muscle phosphocreatine concentration ([PCr]) kinetics, as assessed using 31 P magnetic resonance spectroscopy, following the onset and offset of both moderate-intensity (Mod) and heavy-intensity (Hvy) exercise. Seven healthy males (age 29 ± 6 yr, mean ± SD) completed a series of square-wave transitions to Mod and Hvy knee extensor exercise inside the bore of a 1.5-T superconducting magnet both before and after a 5-day period of Cr loading (4× 5 g/day of creatine monohydrate). Cr supplementation resulted in an ∼8% increase in the resting muscle [PCr]-to-[ATP] ratio (4.66 ± 0.27 vs. 5.04 ± 0.22; P < 0.05), consistent with a significant increase in muscle total Cr content consequent to the intervention. The time constant for muscle [PCr] kinetics was increased following Cr loading for Mod exercise (control: 15 ± 8 vs. Cr: 25 ± 9 s; P < 0.05) and subsequent recovery (control: 14 ± 8 vs. Cr: 27 ± 8 s; P < 0.05) and for Hvy exercise (control: 54 ± 18 vs. Cr: 72 ± 30 s; P < 0.05), but not for subsequent recovery (control: 41 ± 11 vs. Cr: 44 ± 6 s). The magnitude of the increase in [PCr] following Cr loading was correlated ( P < 0.05) with the extent of the slowing of the [PCr] kinetics for the moderate off-transient ( r = 0.92) and the heavy on-transient ( r = 0.71). These data demonstrate, for the first time in humans, that an increase in muscle [PCr] results in a slowing of [PCr] dynamics in exercise and subsequent recovery." @default.
• W2135655272 created "2016-06-24" @default.
• W2135655272 creator A5062262348 @default.
• W2135655272 creator A5072915358 @default.
• W2135655272 creator A5084204500 @default.
• W2135655272 date "2009-04-01" @default.
• W2135655272 modified "2023-10-15" @default.
• W2135655272 title "Influence of dietary creatine supplementation on muscle phosphocreatine kinetics during knee-extensor exercise in humans" @default.
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• W2135655272 doi "https://doi.org/10.1152/ajpregu.90896.2008" @default.
• W2135655272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19211722" @default.
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