Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135655382> ?p ?o ?g. }
- W2135655382 endingPage "E126" @default.
- W2135655382 startingPage "E102" @default.
- W2135655382 abstract "In recent years, an important role has emerged for the glycan-binding protein Galectin-9 (Gal-9) in health and disease. In normal physiology, Gal-9 seems to be a pivotal modulator of T-cell immunity by inducing apoptosis in specific T-cell subpopulations. Because these T-cell populations are associated with autoimmunity, inflammatory disease, and graft rejection, it was postulated that application of exogenous Gal-9 may limit pathogenic T-cell activity. Indeed, treatment with recombinant Gal-9 ameliorates disease activity in various preclinical models of autoimmunity and allograft graft rejection. In many solid cancers, the loss of Gal-9 expression is closely associated with metastatic progression. In line with this observation, treatment with recombinant Gal-9 prevents metastatic spread in various preclinical cancer models. In addition, various hematological malignancies are sensitive to apoptotic elimination by recombinant Gal-9. Here, we review the biology and physiological role of this versatile lectin and discuss the therapeutic potential of Gal-9 in various diseases, including autoimmunity, asthma, infection, and cancer." @default.
- W2135655382 created "2016-06-24" @default.
- W2135655382 creator A5017438678 @default.
- W2135655382 creator A5019749108 @default.
- W2135655382 creator A5041782447 @default.
- W2135655382 creator A5088498222 @default.
- W2135655382 date "2011-07-26" @default.
- W2135655382 modified "2023-10-11" @default.
- W2135655382 title "Therapeutic potential of Galectin-9 in human disease" @default.
- W2135655382 cites W1504039575 @default.
- W2135655382 cites W1536028944 @default.
- W2135655382 cites W1565255833 @default.
- W2135655382 cites W1585589080 @default.
- W2135655382 cites W1638424324 @default.
- W2135655382 cites W1856206988 @default.
- W2135655382 cites W1905064515 @default.
- W2135655382 cites W1915191412 @default.
- W2135655382 cites W1937813437 @default.
- W2135655382 cites W1964180982 @default.
- W2135655382 cites W1964183888 @default.
- W2135655382 cites W1966193262 @default.
- W2135655382 cites W1968258685 @default.
- W2135655382 cites W1969925688 @default.
- W2135655382 cites W1972073222 @default.
- W2135655382 cites W1974182660 @default.
- W2135655382 cites W1977099149 @default.
- W2135655382 cites W1979663953 @default.
- W2135655382 cites W1983744239 @default.
- W2135655382 cites W1985997449 @default.
- W2135655382 cites W1988277159 @default.
- W2135655382 cites W1991166933 @default.
- W2135655382 cites W1992678792 @default.
- W2135655382 cites W1993169978 @default.
- W2135655382 cites W1993528700 @default.
- W2135655382 cites W1994257755 @default.
- W2135655382 cites W2004150448 @default.
- W2135655382 cites W2004169414 @default.
- W2135655382 cites W2008382341 @default.
- W2135655382 cites W2009432847 @default.
- W2135655382 cites W2011771128 @default.
- W2135655382 cites W2012285230 @default.
- W2135655382 cites W2013177587 @default.
- W2135655382 cites W2018426264 @default.
- W2135655382 cites W2019382794 @default.
- W2135655382 cites W2020450604 @default.
- W2135655382 cites W2021379322 @default.
- W2135655382 cites W2021551516 @default.
- W2135655382 cites W2021682946 @default.
- W2135655382 cites W2021716106 @default.
- W2135655382 cites W2028195000 @default.
- W2135655382 cites W2031763684 @default.
- W2135655382 cites W2035187088 @default.
- W2135655382 cites W2035759292 @default.
- W2135655382 cites W2035882944 @default.
- W2135655382 cites W2038509206 @default.
- W2135655382 cites W2039195076 @default.
- W2135655382 cites W2041659209 @default.
- W2135655382 cites W2045231302 @default.
- W2135655382 cites W2047699390 @default.
- W2135655382 cites W2049247376 @default.
- W2135655382 cites W2049652679 @default.
- W2135655382 cites W2053289663 @default.
- W2135655382 cites W2053608295 @default.
- W2135655382 cites W2053739815 @default.
- W2135655382 cites W2053959071 @default.
- W2135655382 cites W2055148102 @default.
- W2135655382 cites W2062037349 @default.
- W2135655382 cites W2063459223 @default.
- W2135655382 cites W2063480128 @default.
- W2135655382 cites W2063874265 @default.
- W2135655382 cites W2065777400 @default.
- W2135655382 cites W2067868934 @default.
- W2135655382 cites W2068473916 @default.
- W2135655382 cites W2070468129 @default.
- W2135655382 cites W2070631889 @default.
- W2135655382 cites W2072772016 @default.
- W2135655382 cites W2075995337 @default.
- W2135655382 cites W2078636414 @default.
- W2135655382 cites W2080559510 @default.
- W2135655382 cites W2081689799 @default.
- W2135655382 cites W2084881844 @default.
- W2135655382 cites W2085269809 @default.
- W2135655382 cites W2090020016 @default.
- W2135655382 cites W2098532474 @default.
- W2135655382 cites W2100368894 @default.
- W2135655382 cites W2112101426 @default.
- W2135655382 cites W2117832286 @default.
- W2135655382 cites W2118725525 @default.
- W2135655382 cites W2121525901 @default.
- W2135655382 cites W2123456305 @default.
- W2135655382 cites W2127141341 @default.
- W2135655382 cites W2132054009 @default.
- W2135655382 cites W2132543133 @default.
- W2135655382 cites W2133737923 @default.
- W2135655382 cites W2134496632 @default.
- W2135655382 cites W2136383251 @default.
- W2135655382 cites W2136732030 @default.
- W2135655382 cites W2140684466 @default.