FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135655954> ?p ?o ?g. }

• W2135655954 endingPage "E881" @default.
• W2135655954 startingPage "E870" @default.
• W2135655954 abstract "Studies of cardiac fuel metabolism in mice have been almost exclusively conducted ex vivo. The major aim of this study was to assess in vivo plasma FFA and glucose utilization by the hearts of healthy control ( db/+) and diabetic ( db/db) mice, based on cardiac uptake of (R)-2-[9,10- 3 H]bromopalmitate ([ 3 H]R-BrP) and 2-deoxy-d-[U- 14 C]glucose tracers. To obtain quantitative information about the evaluation of cardiac FFA utilization with [ 3 H]R-BrP, simultaneous comparisons of [ 3 H]R-BrP and [ 14 C]palmitate ([ 14 C]P) uptake were first made in isolated perfused working hearts from db/+ mice. It was found that [ 3 H]R-BrP uptake was closely correlated with [ 14 C]P oxidation ( r 2 = 0.94, P < 0.001). Then, methods for in vivo application of [ 3 H]R-BrP and [ 14 C]2-DG previously developed for application in the rat were specially adapted for use in the mouse. The method yields indexes of cardiac FFA utilization ( R f *) and clearance ( K f *), as well as glucose utilization ( R g ′). Finally, in the main part of the study, the ability of the heart to switch between FFA and glucose fuels (metabolic flexibility) was investigated by studying anesthetized, 8-h-fasted control and db/db mice in either the basal state or during glucose infusion. In control mice, glucose infusion raised plasma levels of glucose and insulin, raised R g ′ (+58%), and lowered plasma FFA level (−48%), K f * (−45%), and R f * (−70%). This apparent reciprocal regulation of glucose and FFA utilization by control hearts illustrates metabolic flexibility for substrate use. By contrast, in the db/db mice, glucose infusion raised glucose levels with no apparent influence on cardiac FFA or glucose utilization. In conclusion, tracer methodology for assessing in vivo tissue-specific plasma FFA and glucose utilization has been adapted for use in mice and reveals a profound loss of metabolic flexibility in the diabetic db/db heart, suggesting a fixed level of FFA oxidation in fasted and glucose-infused states." @default.
• W2135655954 created "2016-06-24" @default.
• W2135655954 creator A5014232110 @default.
• W2135655954 creator A5025071233 @default.
• W2135655954 creator A5037960708 @default.
• W2135655954 creator A5043100525 @default.
• W2135655954 creator A5059105070 @default.
• W2135655954 creator A5066815897 @default.
• W2135655954 creator A5084422241 @default.
• W2135655954 creator A5091348899 @default.
• W2135655954 date "2006-05-01" @default.
• W2135655954 modified "2023-09-26" @default.
• W2135655954 title "Cardiac metabolism in mice: tracer method developments and in vivo application revealing profound metabolic inflexibility in diabetes" @default.
• W2135655954 cites W121967333 @default.
• W2135655954 cites W1910630598 @default.
• W2135655954 cites W1953419063 @default.
• W2135655954 cites W1979759472 @default.
• W2135655954 cites W1981542683 @default.
• W2135655954 cites W1992304922 @default.
• W2135655954 cites W2006926027 @default.
• W2135655954 cites W2009509125 @default.
• W2135655954 cites W2009551625 @default.
• W2135655954 cites W2013117759 @default.
• W2135655954 cites W2016979581 @default.
• W2135655954 cites W2021871393 @default.
• W2135655954 cites W2038890731 @default.
• W2135655954 cites W2042785858 @default.
• W2135655954 cites W2054005523 @default.
• W2135655954 cites W2058035905 @default.
• W2135655954 cites W2058536977 @default.
• W2135655954 cites W2064794582 @default.
• W2135655954 cites W2072509458 @default.
• W2135655954 cites W2076446417 @default.
• W2135655954 cites W2096702475 @default.
• W2135655954 cites W2101813970 @default.
• W2135655954 cites W2105265053 @default.
• W2135655954 cites W2105711870 @default.
• W2135655954 cites W2106411160 @default.
• W2135655954 cites W2106497166 @default.
• W2135655954 cites W2107447005 @default.
• W2135655954 cites W2110490489 @default.
• W2135655954 cites W2111410515 @default.
• W2135655954 cites W2114671826 @default.
• W2135655954 cites W2136776926 @default.
• W2135655954 cites W2137109606 @default.
• W2135655954 cites W2148517741 @default.
• W2135655954 cites W2150336836 @default.
• W2135655954 cites W2151457614 @default.
• W2135655954 cites W2152212771 @default.
• W2135655954 cites W2156137058 @default.
• W2135655954 cites W2166313641 @default.
• W2135655954 cites W2166788192 @default.
• W2135655954 cites W2169281727 @default.
• W2135655954 cites W2225395848 @default.
• W2135655954 cites W2274037724 @default.
• W2135655954 cites W2416302321 @default.
• W2135655954 cites W2913709946 @default.
• W2135655954 cites W2949909908 @default.
• W2135655954 cites W4253185896 @default.
• W2135655954 cites W43695440 @default.
• W2135655954 doi "https://doi.org/10.1152/ajpendo.00233.2005" @default.
• W2135655954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16352676" @default.
• W2135655954 hasPublicationYear "2006" @default.
• W2135655954 type Work @default.
• W2135655954 sameAs 2135655954 @default.
• W2135655954 citedByCount "46" @default.
• W2135655954 countsByYear W21356559542012 @default.
• W2135655954 countsByYear W21356559542013 @default.
• W2135655954 countsByYear W21356559542014 @default.
• W2135655954 countsByYear W21356559542015 @default.
• W2135655954 countsByYear W21356559542016 @default.
• W2135655954 countsByYear W21356559542017 @default.
• W2135655954 countsByYear W21356559542018 @default.
• W2135655954 countsByYear W21356559542019 @default.
• W2135655954 countsByYear W21356559542022 @default.
• W2135655954 countsByYear W21356559542023 @default.
• W2135655954 crossrefType "journal-article" @default.
• W2135655954 hasAuthorship W2135655954A5014232110 @default.
• W2135655954 hasAuthorship W2135655954A5025071233 @default.
• W2135655954 hasAuthorship W2135655954A5037960708 @default.
• W2135655954 hasAuthorship W2135655954A5043100525 @default.
• W2135655954 hasAuthorship W2135655954A5059105070 @default.
• W2135655954 hasAuthorship W2135655954A5066815897 @default.
• W2135655954 hasAuthorship W2135655954A5084422241 @default.
• W2135655954 hasAuthorship W2135655954A5091348899 @default.
• W2135655954 hasConcept C126322002 @default.
• W2135655954 hasConcept C134018914 @default.
• W2135655954 hasConcept C150903083 @default.
• W2135655954 hasConcept C17093226 @default.
• W2135655954 hasConcept C185592680 @default.
• W2135655954 hasConcept C207001950 @default.
• W2135655954 hasConcept C26291073 @default.
• W2135655954 hasConcept C2777866211 @default.
• W2135655954 hasConcept C2778024521 @default.
• W2135655954 hasConcept C2779306644 @default.
• W2135655954 hasConcept C3020574416 @default.
• W2135655954 hasConcept C62231903 @default.
• W2135655954 hasConcept C71924100 @default.

• next