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- W2135668812 abstract "G-protein-coupled receptor kinases (GRKs) comprise a family of seven mammalian serine/threonine protein kinases that phosphorylate and regulate agonist-bound, activated, G-protein-coupled receptors (GPCRs). GRKs and β-arrestins are key participants in the canonical pathways leading to phosphorylation-dependent GPCR desensitization, endocytosis, intracellular trafficking and resensitization. Here we show that GRK4 isoforms are expressed in human breast cancer but not in normal epithelia. In addition, GRK4-over-expressing cells activated the mitogen-activated protein kinase (MAPK) mediated by ERK 1/2 and JNK phosphorylation in breast cancer-derived cell lines. Furthermore, suppression of β-arrestins decreased GRK4-stimulated ERK 1/2 or JNK phosphorylations. These data indicate that high-level expression of GRK4 may activate MAPK signalling pathways mediated by β-arrestins in breast cancer cells, suggesting that GRK4 may be implicated in breast cancer carcinogenesis. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd." @default.
- W2135668812 created "2016-06-24" @default.
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- W2135668812 date "2008-11-01" @default.
- W2135668812 modified "2023-09-30" @default.
- W2135668812 title "Expression of G protein-coupled receptor kinase 4 is associated with breast cancer tumourigenesis" @default.
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- W2135668812 doi "https://doi.org/10.1002/path.2414" @default.
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