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• W2135679926 abstract "Abstract Dopamine D 1 antagonists have been shown to alter drastically the spontaneous and light-evoked activity of ganglion cells in the rabbit retina (Jensen & Daw, 1984, 1986). A major target of dopaminergic neurons in mammalian retinas appears to be rod All amacrine cells (Pourcho, 1982; Voigt & Wässle, 1987). In the present study, the following questions were addressed: (1) Do dopamine D 1 antagonists alter the activity of ganglion cells through actions primarily on rod All amacrine cells? (2) Are the effects of dopamine D 1 antagonists on ganglion cells due to an inhibition of dopamine-stimulated adenylate cyclase activity? Using an isolated, superfused retinal preparation, the ability of several pharmacological agents to counteract the physiological effects of the dopamine D 1 antagonist (+)-SCH 23390 on rabbit ganglion cells was examined. The glycine antagonist strychnine abolished the effects of (+)-SCH 23390 on the spontaneous and light-evoked activity of OFF-center ganglion cells, whereas the excitatory amino-acid antagonist kynurenic acid abolished the effects of (+)-SCH 23390 on the spontaneous and light-evoked activity of ON-center ganglion cells. The findings obtained with these antagonists can be explained in terms of the known synaptic connections of All amacrine cells. Both 8-(4-chlorophenylthio) cyclic AMP, a membrane-permeable cAMP analog, and forskolin, an activator of adenylate cyclase, reversed the effects of (+)-SCH 23390 on the spontaneous and light-evoked activity of OFF-center ganglion cells but not ON-center ganglion cells. These findings suggest that the effects of dopamine D 1 antagonists on OFF-center ganglion cells are due to an inhibition of dopamine-stimulated adenylate cyclase, with the ensuing lowering of cellular cAMP levels. The effects of dopamine D 1 antagonists on ON-center ganglion cells appear, however, to be independent of intracellular cAMP levels." @default.
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• W2135679926 date "1989-12-01" @default.
• W2135679926 modified "2023-10-17" @default.
• W2135679926 title "Mechanism and site of action of a dopamine D₁ antagonist in the rabbit retina" @default.
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• W2135679926 doi "https://doi.org/10.1017/s0952523800009901" @default.
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