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• W2135689528 abstract "Although tracheal gas insufflation (TGI) has proved to be a useful adjunct to mechanical ventilation, end-inspiratory as well as end-expiratory pressures may increase. We investigated the ability of continuous-flow TGI to maintain eucapnia while reducing airway pressure (Paw) and tidal volume (Vt). Seven sheep (36 ± 2 kg) were ventilated using the Dräger Evita 4 in the pressure control plus mode where flow is released via the expiratory valve to maintain constant inspiratory pressure. To avoid TGI-generated positive end-expiratory pressure (PEEP), a prototype reverse flow TGI tube was used. Two TGI flows (5 and 10 L/min) were investigated pre- and postsaline lavage–induced lung injury. Inspiratory pressures and Vt were significantly reduced as TGI flow increased. At 10 L/min TGI flow the carinal pressures (Pcar) and Vt were reduced pre- and postinjury by 15% and 20%, and by 28% and 34%, respectively. Tidal volume to dead space ratio (Vd/Vt) decreased preinjury from 0.49 ± 0.1 to 0.18 ± 0.2 and postinjury from 0.62 ± 0.1 to 0.33 ± 0.1 at a TGI flow of 10 L/min. The combination of the reverse flow TGI tube and a ventilator with an inspiratory pressure relief mechanism kept set end-inspiratory and end-expiratory pressures constant. This TGI system effectively reduced set Paw and Vt while maintaining eucapnia. Kirmse M, Fujino Y, Hromi J, Mang H, Hess D, Kacmarek RM. Pressure-release tracheal gas insufflation reduces airway pressures in lung-injured sheep maintaining eucapnia." @default.
• W2135689528 created "2016-06-24" @default.
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• W2135689528 date "1999-11-01" @default.
• W2135689528 modified "2023-09-25" @default.
• W2135689528 title "Pressure-release Tracheal Gas Insufflation Reduces Airway Pressures in Lung-injured Sheep Maintaining Eucapnia" @default.
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• W2135689528 doi "https://doi.org/10.1164/ajrccm.160.5.9901030" @default.
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