FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135695770> ?p ?o ?g. }

• W2135695770 endingPage "773" @default.
• W2135695770 startingPage "748" @default.
• W2135695770 abstract "Both high and low circulating urea concentrations, a product of protein metabolism, are associated with decreased fertility in dairy cows through poorly defined mechanisms. The rate of involution and the endometrial ability to mount an adequate innate immune response after calving are both critical for subsequent fertility. Study 1 used microarray analysis to identify genes whose endometrial expression 2 weeks postpartum correlated significantly with the mean plasma urea per cow, ranging from 3.2 to 6.6 mmol/L. The biological functions of 781 mapped genes were analysed using Ingenuity Pathway Analysis. These were predominantly associated with tissue turnover (e.g., BRINP1, FOXG1), immune function (e.g., IL17RB, CRISPLD2), inflammation (e.g., C3, SERPINF1, SERPINF2) and lipid metabolism (e.g., SCAP, ACBD5, SLC10A). Study 2 investigated the relationship between urea concentration and expression of 6 candidate genes (S100A8, HSP5A, IGF1R, IL17RB, BRINP1, CRISPLD2) in bovine endometrial cell culture. These were treated with 0, 2.5, 5.0 or 7.5 mmol/L urea, equivalent to low, medium and high circulating values with or without challenge by bacterial lipopolysaccharide (LPS). LPS increased S100A8 expression as expected but urea treatment had no effect on expression of any tested gene. Examination of the genes/pathways involved suggests that plasma urea levels may reflect variations in lipid metabolism. Our results suggest that it is the effects of lipid metabolism rather than the urea concentration which probably alter the rate of involution and innate immune response, in turn influencing subsequent fertility." @default.
• W2135695770 created "2016-06-24" @default.
• W2135695770 creator A5009334926 @default.
• W2135695770 creator A5014923661 @default.
• W2135695770 creator A5058959439 @default.
• W2135695770 creator A5080270704 @default.
• W2135695770 creator A5085725824 @default.
• W2135695770 date "2015-08-14" @default.
• W2135695770 modified "2023-10-10" @default.
• W2135695770 title "Relationships between Circulating Urea Concentrations and Endometrial Function in Postpartum Dairy Cows" @default.
• W2135695770 cites W1243755060 @default.
• W2135695770 cites W163825304 @default.
• W2135695770 cites W1680078277 @default.
• W2135695770 cites W1805155421 @default.
• W2135695770 cites W1882711636 @default.
• W2135695770 cites W1970714799 @default.
• W2135695770 cites W1970743470 @default.
• W2135695770 cites W1976066285 @default.
• W2135695770 cites W1977751042 @default.
• W2135695770 cites W1980055551 @default.
• W2135695770 cites W1982228553 @default.
• W2135695770 cites W1982930870 @default.
• W2135695770 cites W1988274932 @default.
• W2135695770 cites W1988534112 @default.
• W2135695770 cites W1994752070 @default.
• W2135695770 cites W1999006762 @default.
• W2135695770 cites W2003946092 @default.
• W2135695770 cites W2008163846 @default.
• W2135695770 cites W2008968931 @default.
• W2135695770 cites W2026516154 @default.
• W2135695770 cites W2033037262 @default.
• W2135695770 cites W2033655260 @default.
• W2135695770 cites W2038793661 @default.
• W2135695770 cites W2043511949 @default.
• W2135695770 cites W2046454491 @default.
• W2135695770 cites W2054670584 @default.
• W2135695770 cites W2062786336 @default.
• W2135695770 cites W2062807264 @default.
• W2135695770 cites W2063698811 @default.
• W2135695770 cites W2063787422 @default.
• W2135695770 cites W2074404034 @default.
• W2135695770 cites W2075192834 @default.
• W2135695770 cites W2075781716 @default.
• W2135695770 cites W2079259464 @default.
• W2135695770 cites W2084606817 @default.
• W2135695770 cites W2095798808 @default.
• W2135695770 cites W2097741555 @default.
• W2135695770 cites W2099733170 @default.
• W2135695770 cites W2102428962 @default.
• W2135695770 cites W2102663075 @default.
• W2135695770 cites W2105329599 @default.
• W2135695770 cites W2108542410 @default.
• W2135695770 cites W2110738555 @default.
• W2135695770 cites W2121202050 @default.
• W2135695770 cites W2129044490 @default.
• W2135695770 cites W2133448557 @default.
• W2135695770 cites W2144920139 @default.
• W2135695770 cites W2145120842 @default.
• W2135695770 cites W2147412811 @default.
• W2135695770 cites W2148149623 @default.
• W2135695770 cites W2149166823 @default.
• W2135695770 cites W2149328686 @default.
• W2135695770 cites W2150237507 @default.
• W2135695770 cites W2155875076 @default.
• W2135695770 cites W2158710925 @default.
• W2135695770 cites W2159660882 @default.
• W2135695770 cites W2162098634 @default.
• W2135695770 cites W2162368163 @default.
• W2135695770 cites W2165060628 @default.
• W2135695770 cites W2166885691 @default.
• W2135695770 cites W2171083495 @default.
• W2135695770 cites W2188232396 @default.
• W2135695770 cites W2406546435 @default.
• W2135695770 cites W2419651250 @default.
• W2135695770 cites W50319813 @default.
• W2135695770 cites W64358887 @default.
• W2135695770 cites W76323127 @default.
• W2135695770 cites W76893505 @default.
• W2135695770 doi "https://doi.org/10.3390/ani5030382" @default.
• W2135695770 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4598704" @default.
• W2135695770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26479384" @default.
• W2135695770 hasPublicationYear "2015" @default.
• W2135695770 type Work @default.
• W2135695770 sameAs 2135695770 @default.
• W2135695770 citedByCount "16" @default.
• W2135695770 countsByYear W21356957702017 @default.
• W2135695770 countsByYear W21356957702018 @default.
• W2135695770 countsByYear W21356957702019 @default.
• W2135695770 countsByYear W21356957702020 @default.
• W2135695770 countsByYear W21356957702021 @default.
• W2135695770 countsByYear W21356957702022 @default.
• W2135695770 countsByYear W21356957702023 @default.
• W2135695770 crossrefType "journal-article" @default.
• W2135695770 hasAuthorship W2135695770A5009334926 @default.
• W2135695770 hasAuthorship W2135695770A5014923661 @default.
• W2135695770 hasAuthorship W2135695770A5058959439 @default.
• W2135695770 hasAuthorship W2135695770A5080270704 @default.
• W2135695770 hasAuthorship W2135695770A5085725824 @default.

• next