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- W2135722038 endingPage "393" @default.
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- W2135722038 abstract "Primary central nervous system lymphoma has undergone a remarkable increase in incidence over the last decade, both in immunosuppressed and immunocompetent individuals. Its clinicopathologic evaluation requires knowledge of current hematopathologic systems for lymphoma classification, as well as specific understanding of unique central nervous system determinants. In immunocompromised individuals, the tumor has a constant association with Epstein-Barr virus. The form of Epstein-Barr virus in these tumors appears to be predominantly latent, however, the precise mechanism relating virus to tumor pathogenesis is still unclear. In immunocompetent patients, risk factors and oncogenic associations are completely unknown. Critical to the formation of these tumors is the trafficking of B-cells, whether pre- or post-transformation, across the blood-brain barrier. These B-cell migrations may require perturbations to the barrier that originate in or around neural parenchyma, such as localized injury or infection." @default.
- W2135722038 created "2016-06-24" @default.
- W2135722038 creator A5000160515 @default.
- W2135722038 date "1995-10-01" @default.
- W2135722038 modified "2023-10-16" @default.
- W2135722038 title "Pathogenesis and Classification of Primary Central Nervous System Lymphoma: An Update" @default.
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- W2135722038 doi "https://doi.org/10.1111/j.1750-3639.1995.tb00616.x" @default.
- W2135722038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8974621" @default.
- W2135722038 hasPublicationYear "1995" @default.
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