FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135741828> ?p ?o ?g. }

• W2135741828 endingPage "E837" @default.
• W2135741828 startingPage "E832" @default.
• W2135741828 abstract "Hyperglucagonemia following oral glucose ingestion in patients with type 1 diabetes (and type 2 diabetes) has been claimed to result from impaired intraislet insulin inhibition of glucagon. We looked at plasma glucagon responses to the oral glucose tolerance test (OGTT) and isoglycemic intravenous glucose infusion (IIGI) in patients with type 1 diabetes. Nine patients without residual beta-cell function [age: 25 +/- 9 yr; body mass index (BMI): 24 +/- 2 kg/m(2); fasting plasma glucose (FPG): 9.5 +/- 2.1 mM; Hb A(1c): 8.4 +/- 1.2% (mean +/- SD)] and eight healthy subjects (age: 28 +/- 5 yr; BMI: 24 +/- 3 kg/m(2); FPG: 5.3 +/- 0.2 mM; Hb A(1c): 5.0 +/- 0.1%) were examined on two separate occasions: 4-h 50-g OGTT and IIGI. Isoglycemia during IIGIs was obtained using 53 +/- 5 g of glucose in patients with type 1 diabetes and 30 +/- 3 g in control subjects (P < 0.001), resulting in gastrointestinal-mediated glucose disposal [100% x (glucose(OGTT) - glucose(IIGI)/glucose(OGTT))] of -6 +/- 9 and 40 +/- 6% (P < 0.01), respectively. Equal glucagon suppression during the two glucose stimuli was observed in healthy subjects, whereas patients with type 1 diabetes exhibited less inhibition in response to OGTT compared with IIGI (AUC: 1,519 +/- 129 vs. 1,240 +/- 86 pM.4 h; P = 0.03). This difference was even more pronounced during the initial 40 min with paradoxical hypersecretion of glucagon during OGTT and suppression during IIGI (AUC: 37 +/- 13 vs. -33 +/- 16 pM.40 min; P = 0.02). These results suggest that the inappropriate glucagon response to glucose in patients with type 1 diabetes occurs as a consequence of the oral administration way, suggesting a role of the gastrointestinal tract, possibly via glucagonotropic signaling from gut hormones (e.g., glucose-dependent insulinotropic polypeptide), in type 1 diabetic hyperglucagonemia." @default.
• W2135741828 created "2016-06-24" @default.
• W2135741828 creator A5004120950 @default.
• W2135741828 creator A5011803647 @default.
• W2135741828 creator A5079352451 @default.
• W2135741828 creator A5085434984 @default.
• W2135741828 date "2010-04-01" @default.
• W2135741828 modified "2023-10-16" @default.
• W2135741828 title "Inappropriate glucagon response after oral compared with isoglycemic intravenous glucose administration in patients with type 1 diabetes" @default.
• W2135741828 cites W1969867564 @default.
• W2135741828 cites W1969932276 @default.
• W2135741828 cites W1977053079 @default.
• W2135741828 cites W1989064065 @default.
• W2135741828 cites W2004977380 @default.
• W2135741828 cites W2023104869 @default.
• W2135741828 cites W2025025361 @default.
• W2135741828 cites W2054564814 @default.
• W2135741828 cites W2059944910 @default.
• W2135741828 cites W2061865038 @default.
• W2135741828 cites W2065435558 @default.
• W2135741828 cites W2067095827 @default.
• W2135741828 cites W2067102849 @default.
• W2135741828 cites W2073625634 @default.
• W2135741828 cites W2080128749 @default.
• W2135741828 cites W2087707716 @default.
• W2135741828 cites W2103121999 @default.
• W2135741828 cites W2104938107 @default.
• W2135741828 cites W2106036385 @default.
• W2135741828 cites W2111675794 @default.
• W2135741828 cites W2113932514 @default.
• W2135741828 cites W2132802847 @default.
• W2135741828 cites W2139121435 @default.
• W2135741828 cites W2144173589 @default.
• W2135741828 cites W2145818242 @default.
• W2135741828 cites W2153770190 @default.
• W2135741828 cites W2167084703 @default.
• W2135741828 cites W2283885169 @default.
• W2135741828 cites W4253699883 @default.
• W2135741828 doi "https://doi.org/10.1152/ajpendo.00700.2009" @default.
• W2135741828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20103744" @default.
• W2135741828 hasPublicationYear "2010" @default.
• W2135741828 type Work @default.
• W2135741828 sameAs 2135741828 @default.
• W2135741828 citedByCount "66" @default.
• W2135741828 countsByYear W21357418282012 @default.
• W2135741828 countsByYear W21357418282013 @default.
• W2135741828 countsByYear W21357418282014 @default.
• W2135741828 countsByYear W21357418282015 @default.
• W2135741828 countsByYear W21357418282016 @default.
• W2135741828 countsByYear W21357418282017 @default.
• W2135741828 countsByYear W21357418282018 @default.
• W2135741828 countsByYear W21357418282019 @default.
• W2135741828 countsByYear W21357418282020 @default.
• W2135741828 countsByYear W21357418282021 @default.
• W2135741828 countsByYear W21357418282022 @default.
• W2135741828 countsByYear W21357418282023 @default.
• W2135741828 crossrefType "journal-article" @default.
• W2135741828 hasAuthorship W2135741828A5004120950 @default.
• W2135741828 hasAuthorship W2135741828A5011803647 @default.
• W2135741828 hasAuthorship W2135741828A5079352451 @default.
• W2135741828 hasAuthorship W2135741828A5085434984 @default.
• W2135741828 hasConcept C126322002 @default.
• W2135741828 hasConcept C134018914 @default.
• W2135741828 hasConcept C2777180221 @default.
• W2135741828 hasConcept C2778563252 @default.
• W2135741828 hasConcept C2779306644 @default.
• W2135741828 hasConcept C2780221984 @default.
• W2135741828 hasConcept C2908748658 @default.
• W2135741828 hasConcept C555293320 @default.
• W2135741828 hasConcept C71924100 @default.
• W2135741828 hasConceptScore W2135741828C126322002 @default.
• W2135741828 hasConceptScore W2135741828C134018914 @default.
• W2135741828 hasConceptScore W2135741828C2777180221 @default.
• W2135741828 hasConceptScore W2135741828C2778563252 @default.
• W2135741828 hasConceptScore W2135741828C2779306644 @default.
• W2135741828 hasConceptScore W2135741828C2780221984 @default.
• W2135741828 hasConceptScore W2135741828C2908748658 @default.
• W2135741828 hasConceptScore W2135741828C555293320 @default.
• W2135741828 hasConceptScore W2135741828C71924100 @default.
• W2135741828 hasIssue "4" @default.
• W2135741828 hasLocation W21357418281 @default.
• W2135741828 hasLocation W21357418282 @default.
• W2135741828 hasOpenAccess W2135741828 @default.
• W2135741828 hasPrimaryLocation W21357418281 @default.
• W2135741828 hasRelatedWork W1855195526 @default.
• W2135741828 hasRelatedWork W1978037308 @default.
• W2135741828 hasRelatedWork W1979975085 @default.
• W2135741828 hasRelatedWork W2002695797 @default.
• W2135741828 hasRelatedWork W2050763953 @default.
• W2135741828 hasRelatedWork W2091083050 @default.
• W2135741828 hasRelatedWork W2099375768 @default.
• W2135741828 hasRelatedWork W2400917451 @default.
• W2135741828 hasRelatedWork W2970161534 @default.
• W2135741828 hasRelatedWork W2337002345 @default.
• W2135741828 hasVolume "298" @default.
• W2135741828 isParatext "false" @default.
• W2135741828 isRetracted "false" @default.
• W2135741828 magId "2135741828" @default.

• next