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• W2135761574 startingPage "553" @default.
• W2135761574 abstract "After decades of epidemiological and clinical research, the influence of overall diet on health and disease, particularly coronary heart disease (CHD), has become widely accepted.1 The pioneering ecological and metabolic studies of Keys and colleagues2 placed the focus on fat types, showing that populations consuming more saturated fatty acids (SFAs) had higher blood cholesterol levels and associated higher rates of CHD, whereas individuals fed SFAs had increased blood cholesterol levels, as opposed to the effects of monounsaturated or polyunsaturated fatty acids (PUFAs). Cholesterol changes derived from switching fatty acid species in the diet were found to be predictable with specific equations.3–5 Subsequent epidemiological studies confirmed that elevated serum cholesterol was a strong independent risk factor for CHD. This led to the formulation of the diet-heart hypothesis, whereby the high intake of saturated fats leads to elevated cholesterol levels, which in turn promote atherosclerosis, coronary artery occlusion, and subsequent ischemic events.6 Although the diet-heart hypothesis shaped dietary guidelines toward reduction of all dietary fat, with a concomitant increase in carbohydrates, a low-fat approach was not effective in reducing the incidence of cardiovascular disease (CVD) in women.7 In the past 3 decades, the decreasing fat consumption as a percentage of energy in the US population has done little to slow the increasing rates of obesity and type 2 diabetes mellitus (T2DM).8 It is now widely recognized that higher-fat diets can be beneficial if healthy fats are consumed, whereas high-carbohydrate diets (particularly those with high glycemic load) might be contributing to CHD9–12 and other negative health outcomes.12,13 As reviewed here, healthy, plant-based unsaturated fats are major components of widely consumed edible seeds, such as tree nuts and peanuts.More important …" @default.
• W2135761574 created "2016-06-24" @default.
• W2135761574 creator A5030130509 @default.
• W2135761574 creator A5056459536 @default.
• W2135761574 date "2013-07-30" @default.
• W2135761574 modified "2023-10-12" @default.
• W2135761574 title "Consumption of Plant Seeds and Cardiovascular Health" @default.
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