FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135765865> ?p ?o ?g. }

• W2135765865 endingPage "1274" @default.
• W2135765865 startingPage "1265" @default.
• W2135765865 abstract "Mechanical stress plays an important role in proliferation of venous smooth muscle cells (SMCs) in neointima, a process of formation that contributes to failure of vein grafts. However, it is unknown what intracellular growth signal leads to proliferation of venous SMCs.The objective of this study is to identify mechanisms of mechanical stretch on neointima formation.By a microarray analysis, we found that mechanical cyclic stretch (15% elongation) stimulated the transcription of SGK-1 (serum-, glucocorticoid-regulated kinase-1). Mechanical stretch-induced SGK-1 mRNA expression was blocked by actinomycin D. The mechanism for the SGK-1 expression involved MEK1 but not p38 or JNK signaling pathway. SGK-1 activation in response to stretch is blocked by insulin-like growth factor (IGF)-1 receptor inhibitor and mammalian target of rapamycin complex (mTORC)2 inhibitor (Ku-0063794) but not mTORC1 inhibitor (rapamycin). Mechanical stretch-induced bromodeoxyuridine incorporation was reduced by 83.5% in venous SMCs isolated from SGK-1 knockout mice. In contrast, inhibition of Akt, another downstream signal of PI3K resulted in only partial inhibition of mechanical stretch-induced proliferation of venous SMCs. Mechanical stretch also induced phosphorylation and nuclear exportation of p27(kip1), whereas knockout of SGK-1 attenuated this effect of mechanical stretch on p27(kip1). In vivo, we found that placement of a vein graft into artery increased SGK-1 expression. Knockout of SGK-1 effectively prevented neointima formation in vein graft. There is significant lower level of p27(kip1) located in the nucleus of neointima cells in SGK-1 knockout mice compared with that of wild-type vein graft. In addition, we also found that wire injury of artery or growth factors in vitro increased expression of SGK-1.These results suggest that SGK-1 is an injury-responsive kinase that could mediate mechanical stretch-induced proliferation of vascular cells in vein graft, leading to neointima formation." @default.
• W2135765865 created "2016-06-24" @default.
• W2135765865 creator A5000395076 @default.
• W2135765865 creator A5008233208 @default.
• W2135765865 creator A5031524039 @default.
• W2135765865 creator A5046958803 @default.
• W2135765865 creator A5058814917 @default.
• W2135765865 creator A5062335919 @default.
• W2135765865 creator A5067028141 @default.
• W2135765865 creator A5078754940 @default.
• W2135765865 creator A5086672036 @default.
• W2135765865 date "2010-11-12" @default.
• W2135765865 modified "2023-10-13" @default.
• W2135765865 title "The Mechanical Stress–Activated Serum-, Glucocorticoid-Regulated Kinase 1 Contributes to Neointima Formation in Vein Grafts" @default.
• W2135765865 cites W1921428702 @default.
• W2135765865 cites W1963657903 @default.
• W2135765865 cites W1967296654 @default.
• W2135765865 cites W1980848382 @default.
• W2135765865 cites W1986510344 @default.
• W2135765865 cites W1992170852 @default.
• W2135765865 cites W1992322558 @default.
• W2135765865 cites W2008876523 @default.
• W2135765865 cites W2020564204 @default.
• W2135765865 cites W2029787353 @default.
• W2135765865 cites W2032791044 @default.
• W2135765865 cites W2033390204 @default.
• W2135765865 cites W2062133752 @default.
• W2135765865 cites W2074503707 @default.
• W2135765865 cites W2076383063 @default.
• W2135765865 cites W2080904829 @default.
• W2135765865 cites W2090193213 @default.
• W2135765865 cites W2092282197 @default.
• W2135765865 cites W2096571949 @default.
• W2135765865 cites W2099544753 @default.
• W2135765865 cites W2106937081 @default.
• W2135765865 cites W2111123535 @default.
• W2135765865 cites W2128987179 @default.
• W2135765865 cites W2129750730 @default.
• W2135765865 cites W2129976875 @default.
• W2135765865 cites W2146013126 @default.
• W2135765865 cites W2152463997 @default.
• W2135765865 cites W2160361307 @default.
• W2135765865 cites W2166171562 @default.
• W2135765865 cites W4238567307 @default.
• W2135765865 cites W4253861185 @default.
• W2135765865 doi "https://doi.org/10.1161/circresaha.110.222588" @default.
• W2135765865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20884880" @default.
• W2135765865 hasPublicationYear "2010" @default.
• W2135765865 type Work @default.
• W2135765865 sameAs 2135765865 @default.
• W2135765865 citedByCount "48" @default.
• W2135765865 countsByYear W21357658652012 @default.
• W2135765865 countsByYear W21357658652013 @default.
• W2135765865 countsByYear W21357658652014 @default.
• W2135765865 countsByYear W21357658652015 @default.
• W2135765865 countsByYear W21357658652016 @default.
• W2135765865 countsByYear W21357658652017 @default.
• W2135765865 countsByYear W21357658652018 @default.
• W2135765865 countsByYear W21357658652019 @default.
• W2135765865 countsByYear W21357658652020 @default.
• W2135765865 countsByYear W21357658652022 @default.
• W2135765865 countsByYear W21357658652023 @default.
• W2135765865 crossrefType "journal-article" @default.
• W2135765865 hasAuthorship W2135765865A5000395076 @default.
• W2135765865 hasAuthorship W2135765865A5008233208 @default.
• W2135765865 hasAuthorship W2135765865A5031524039 @default.
• W2135765865 hasAuthorship W2135765865A5046958803 @default.
• W2135765865 hasAuthorship W2135765865A5058814917 @default.
• W2135765865 hasAuthorship W2135765865A5062335919 @default.
• W2135765865 hasAuthorship W2135765865A5067028141 @default.
• W2135765865 hasAuthorship W2135765865A5078754940 @default.
• W2135765865 hasAuthorship W2135765865A5086672036 @default.
• W2135765865 hasBestOaLocation W21357658651 @default.
• W2135765865 hasConcept C126322002 @default.
• W2135765865 hasConcept C170493617 @default.
• W2135765865 hasConcept C182704531 @default.
• W2135765865 hasConcept C184235292 @default.
• W2135765865 hasConcept C185592680 @default.
• W2135765865 hasConcept C2777093181 @default.
• W2135765865 hasConcept C2777339539 @default.
• W2135765865 hasConcept C2778283817 @default.
• W2135765865 hasConcept C2778583881 @default.
• W2135765865 hasConcept C55493867 @default.
• W2135765865 hasConcept C62478195 @default.
• W2135765865 hasConcept C71924100 @default.
• W2135765865 hasConcept C75217442 @default.
• W2135765865 hasConcept C86554907 @default.
• W2135765865 hasConcept C86803240 @default.
• W2135765865 hasConcept C95444343 @default.
• W2135765865 hasConceptScore W2135765865C126322002 @default.
• W2135765865 hasConceptScore W2135765865C170493617 @default.
• W2135765865 hasConceptScore W2135765865C182704531 @default.
• W2135765865 hasConceptScore W2135765865C184235292 @default.
• W2135765865 hasConceptScore W2135765865C185592680 @default.
• W2135765865 hasConceptScore W2135765865C2777093181 @default.
• W2135765865 hasConceptScore W2135765865C2777339539 @default.
• W2135765865 hasConceptScore W2135765865C2778283817 @default.
• W2135765865 hasConceptScore W2135765865C2778583881 @default.

• next